The Translational Microbiome Research Forum is an online resource for scientists engaged in translational microbiome research to access current, topical information and to provide a platform to exchange knowledge and ideas. We encourage you to participate by actively using the commenting system, by submitting events, and by joining our email list to receive updates when new content is posted.

  • Cell Press: Cell Host & Microbe


    The Human Microbiome has been a recent area of intense research, rapid progress, and exciting advances. Cell Host & Microbe has published a diverse array of exciting articles related to The Human Microbiome. In this Collection, we present a selection of recent research and review articles on the topic. Read more at Cell Press: Cell […]

  • How Antibiotics Affect Your Microbiome


    The human gut microbiome is a complex, highly-evolved commensal community with an integral role in your response to disease and how well you maintain homeostasis. While commensal bacteria vary from person to person, a person’s specific microbiome should contain the same relative percentage of bacterial species over their lifespan. The balance of this community can […]

  • Do you know what’s in your water?


    Most researchers know the pain of trying and failing to replicate a published experiment. This can result from something as simple as a poorly written methods section, in which important experimental details have been omitted. Barnett and Gibson recently called out the importance of an in vivo experimental detail that is commonly left out and […]

  • Taconic Biosciences Launches TruBIOME™ to Create Animal Models with Custom Microbiome Profiles


    Rensselaer, NY — April 15, 2019 – Taconic Biosciences, a global leader in providing genetically engineered rodent model solutions, announces the launch of TruBIOME™, a first of its kind solution enabling the generation and maintenance of mice with custom microbiome profiles. TruBIOME™ was developed to meet the research community’s need for a microbiome solution that […]

  • The 5th Annual Arrowhead Translational Microbiome Conference


    The 5th Annual Arrowhead Translational Microbiome Conference (April 16-18 | Boston) recently announced a bonus track for their upcoming annual event, which is taking place in Boston on April 16-18. For additional details visit https://www.microbiomeconference.com/. NEW PRESENTATIONS: Ultra-high Resolution Microbiome Taxonomic Profiling Enabled by Novel High-throughput, High-resolution Assay Design Mark Driscoll, Ph.D., Co-Founder and Chief […]

  • Microbes May Take Some of the Blame for the Reproducibility Crisis

    For the past several years, science has been plagued by what some consider a reproducibility crisis—the idea that many published studies don’t yield the same results when repeated by other scientists, or sometimes even by the same scientists. Surveys and studies have suggested myriad reasons such as unreliable reagents and cell lines, selective statistics, a […]

  • 2019 FNIH Lurie Prize in Biomedical Sciences Winner Uncovered the Microbiome’s Critical Role in Immune Regulation

    NORTH BETHESDA, Md., April 3, 2019 /PRNewswire/ — The Foundation for the National Institutes of Health, Inc. (FNIH) is delighted to name Yasmine Belkaid, Ph.D., the winner of the 2019 Lurie Prize in Biomedical Sciences for blazing a trail in understanding the microbiome’s significant role in immune regulation. The human body houses trillions of microscopic […]

  • Taconic Biosciences Licenses the Wild Mouse Gut Microbiome from the National Institute of Diabetes and Digestive and Kidney Diseases


    RENSSELAER, N.Y., April 01, 2019 (GLOBE NEWSWIRE) — Taconic Biosciences, a global leader in providing genetically engineered rodent model solutions, announces it has obtained a license to the Wild Mouse gut microbiome from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health (NIH). Investigators at the […]

  • Depression and the Microbiome


    New research is regularly being published on the connection between the gut microbiome and the central nervous system (CNS) — together known as the gut-brain axis. Alterations in the composition of intestinal microbiota have also been associated with antibiotic use and the progression of infectious diseases. This Taconic Insight highlights the link between the microbiome […]

  • CD1d Modulates Colonic Inflammation in NOD2−/− Mice by Altering the Intestinal Microbial Composition Comprising Acetatifactor muris


    ABSTRACT AIMS NOD2 and CD1d play a key role in innate immunity by recognizing conserved molecular patterns of pathogens. While NOD2−/− and CD1d−/− mice display structural and functional alterations in Paneth cells, animal studies have reported no impact of NOD2 or CD1d deficiency on experimental colitis. NOD2 mutations increase the susceptibility to inflammatory bowel diseases […]

  • Does MHC heterozygosity influence microbiota form and function?


    ABSTRACT MHC molecules are essential for the adaptive immune response, and they are the most polymorphic genetic loci in vertebrates. Extreme genetic variation at these loci is paradoxical given their central importance to host health. Classic models of MHC gene evolution center on antagonistic host-pathogen interactions to promote gene diversification and allelic diversity in host […]

  • Absence of gut microbiota during early life affects anxiolytic Behaviors and monoamine neurotransmitters system in the hippocampal of mice


    ABSTRACT The gut microbiome is composed of an enormous number of microorganisms, generally regarded as commensal bacteria. Resident gut bacteria are an important contributor to health and significant evidence suggests that the presence of healthy and diverse gut microbiota is important for normal cognitive and emotional processing. Here we measured the expression of monoamine neurotransmitter-related […]

  • Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes


    ABSTRACT We demonstrated that an antibiotic cocktail (ABX)-perturbed gut microbiome is associated with reduced amyloid-β (Aβ) plaque pathology and astrogliosis in the male amyloid precursor protein (APP)SWE/presenilin 1 (PS1)ΔE9 transgenic model of Aβ amyloidosis. We now show that in an independent, aggressive APPSWE/PS1L166P (APPPS1-21) mouse model of Aβ amyloidosis, an ABX-perturbed gut microbiome is associated […]

  • A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip


    ABSTRACT The diverse bacterial populations that comprise the commensal microbiome of the human intestine play a central role in health and disease. A method that sustains complex microbial communities in direct contact with living human intestinal cells and their overlying mucus layer in vitro would thus enable the investigation of host–microbiome interactions. Here, we show […]

  • Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis


    ABSTRACT The gut commensal Bacteroides fragilis or its capsular polysaccharide A (PSA) can prevent various peripheral and CNS sterile inflammatory disorders. Fatal herpes simplex encephalitis (HSE) results from immune pathology caused by uncontrolled invasion of the brainstem by inflammatory monocytes and neutrophils. Here we assess the immunomodulatory potential of PSA in HSE by infecting PSA […]

  • Antibiotics-induced perturbations in gut microbial diversity influence metabolic phenotypes in a murine model of high-fat diet-induced obesity


    ABSTRACT Gut microbiota play a key role in the regulation of obesity and associated metabolic disorders. To study the relationship between them, antibiotics have been widely used to generate pseudo-germ-free rodents as control models. However, it is not clear whether antibiotics impact an animal’s metabolic phenotype. Therefore, the effect of antibiotics-induced gut microbial perturbations on […]

  • Supplementation with compound polysaccharides contributes to the development and metabolic activity of young rat intestinal microbiota

    ABSTRACT Dietary intervention during early life has a significant impact on colonization of the gut microbiota. In addition, some polysaccharides have the potential to selectively stimulate the growth and metabolic activity of intestinal bacteria associated with health and well-being. However, less is known about the effect of polysaccharides on the development of gut microbiota in […]

  • Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease


    ABSTRACT Diabetic kidney disease is a major cause of renal failure that urgently necessitates a breakthrough in disease management. Here we show using untargeted metabolomics that levels of phenyl sulfate, a gut microbiota-derived metabolite, increase with the progression of diabetes in rats overexpressing human uremic toxin transporter SLCO4C1 in the kidney, and are decreased in […]

  • Events
    We maintain a calendar of events and meetings related to the field of Microbiome Research. Check it often for new events and conferences, or submit something for the calendar here.

  • Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice


    Significance Studies using experimental models have indicated that multiple sclerosis (MS)-like disease can be triggered in the gut following interactions of brain autoimmune T lymphocytes with local microbiota.

  • BOOK REVIEW: GNOTOBIOTICS


    Gnotobiotics, edited by Trenton Schoeb and Kathryn Eaton, is invaluable to those developing or managing gnotobiotic facilities.

  • Stress could be just as unhealthy as junk food


    Brigham Young University: We all know that a poor diet is unhealthy, but a new BYU study finds that stress may just as harmful to our bodies as a really bad diet.

  • Infection via mosquito bite alters Zika virus replication kinetics in rhesus macaques


    Abstract For more than three decades it has been recognized that small amounts of vector saliva can significantly alter the infectivity of vector-borne pathogens and subsequent in vivo dynamics.

  • Of Mice, Dirty Mice, and Men: Using Mice To Understand Human Immunology


    Abstract Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans.

  • Microbial Genetic Composition Tunes Host Longevity


    Highlights •Systematic analysis of longevity-promoting microbial genetic variations •Colanic acid as a pro-longevity natural compound effective in different species

  • Learning more about the gut microbiota


    The GMFH editing team recommends these book selections on the topic.

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