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  • Taconic Biosciences Participates in Second Rodent Research Reference Mission to the International Space Station


    Resulting Studies Will Provide Critical Reference Data to Drive Advancements in Human Health Rensselaer, NY — September 3, 2019 – Taconic Biosciences, a global leader in providing genetically engineered animal model solutions, announces its participation in the second Rodent Research Reference (RRR) mission to the International Space Station. Taconic has a history with NASA dating […]

  • The Microbiomics Standards & Controls Initiative


    What is M-SCI? The Microbiomics Standards & Controls Initiative Receive free standards and controls. Improve accuracy and data reproducibility. Help the field of Microbiomics incorporate controls and standards in every experiment. Why Give Away Free Standards & Controls? Availability is Key to Standardization Leaders in the field of microbiomics have recognized that the lack of […]

  • Antimicrobial resistance and the microbiome


    Microbiome, Environmental Microbiome and Animal Microbiome are coming together to launch a special series inviting authors to submit their research pertaining to antimicrobial resistance (AMR) and the microbiome. The emergence and spread of AMR can only be described as a catastrophic problem for human and animal health. It is projected that there would be more […]

  • IBD Severity and Fungi in Microbiome


    The microbiome includes not just bacteria, but also fungi, viruses and parasites. While most of the attention has been on bacterial components of the microbiome, new research links a commensal yeast found on human skin to disease severity in inflammatory bowel disease (IBD). Linking Common Fungi with IBD Severity In a new paper published in […]

  • Remodeling unhealthful gut microbiomes to fight disease


    You are what you eat — right down to the microbiome living in your gut. Diet can affect which microbes are in the intestinal tract, and research has shown that harmful gut microbiome changes can lead to illnesses such as heart disease, obesity and cancer. Today, scientists will report the development of molecules that can […]

  • Nanoparticle relieved symptoms of inflammatory bowel disease in mice


    ANN ARBOR—Researchers at the University of Michigan College of Pharmacy have developed a nanoparticle that alters the gut microbiome and alleviates symptoms of inflammatory bowel disease in mice more effectively than common FDA-approved medications. The gut microbiome––the body’s environment of healthy and unhealthy bacteria––is the next frontier for drug development, and an imbalanced gut microbiome […]

  • FDA Issues Safety Alert on Investigational Use of Fecal Microbiota Transplantation


    Fecal microbiota transplantation (FMT) is the transfer of fecal matter from a healthy individual into a recipient with the goal of treating an ailment. In its simplest form FMT has been used to treat disease with reports detailing its use as far back as 1700 years ago in China1. Modern applications of this procedure have […]

  • New Mouse Model Predicts Two Clinical Trial Failures in Humans


    A new mouse model designed with a microbiome similar to that of wild mice may be a better predictor of human responses to some drugs than commonly used lab mice, according to a study published today in Science. The authors repeated two preclinical studies that had demonstrated positive results in mice only to fail when […]

  • Using a more diverse microbiome, scientists look to create a better lab mouse


    Lab mice are notoriously clean: To prevent introducing anything that could disrupt results, researchers house them in sterile conditions, and the food and water they ingest are monitored for extreme quality. This also means that the mice’s microbiomes — the cohort of microorganisms that reside within all animals and influence many body processes — have […]

  • Effects of theabrownin on serum metabolite and gut microbiome in rats with high-sugar diet


    ABSTRACT Evidence has accumulated that the gut microbiota is an important environmental factor contributing to obesity by altering host energy harvest and storage. We performed a high-throughput 16S rDNA sequencing association study and serum metabolomics profiling in rat with high-sugar diet. Our studies revealed that high sugar diet reduced the diversity of cecal microorganisms, while […]

  • Antibiotics-Driven Gut Microbiome Perturbation Alters Immunity to Vaccines in Humans


    SUMMARY Emerging evidence indicates a central role for the microbiome in immunity. However, causal evidence in humans is sparse. Here, we administered broad-spectrum antibiotics to healthy adults prior and subsequent to seasonal influenza vaccination. Despite a 10,000-fold reduction in gut bacterial load and long-lasting diminution in bacterial diversity, antibody responses were not significantly affected. However, […]

  • Maternal microbiota in pregnancy and early life


    A microbial bond is shared between mother and child that renders the age-old dichotomy of “nature versus nurture” obsolete. Molded by both host biology and the physical relationship between mother and child, this microbial connection is formed at the earliest moments of life when the newborn’s skin and mucosal surfaces are seeded with microorganisms that […]

  • Diet-induced remission in chronic enteropathy is associated with altered microbial community structure and synthesis of secondary bile acids


    ABSTRACT Background The microbiome has been implicated in the initiation and persistence of inflammatory bowel disease. Despite the fact that diet is one of the most potent modulators of microbiome composition and function and that dietary intervention is the first-line therapy for treating pediatric Crohn’s disease, the relationships between diet-induced remission, enteropathy, and microbiome are […]

  • A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research


    ABSTRACT Our understanding of how the gut microbiome interacts with its human host has been restrained by limited access to longitudinal datasets to examine stability and dynamics, and by having only a few isolates to test mechanistic hypotheses. Here, we present the Broad Institute-OpenBiome Microbiome Library (BIO-ML), a comprehensive collection of 7,758 gut bacterial isolates […]

  • Genetic determinants of gut microbiota composition and bile acid profiles in mice


    ABSTRACT The microbial communities that inhabit the distal gut of humans and other mammals exhibit large inter-individual variation. While host genetics is a known factor that influences gut microbiota composition, the mechanisms underlying this variation remain largely unknown. Bile acids (BAs) are hormones that are produced by the host and chemically modified by gut bacteria. […]

  • The gut microbiome derived from anorexia nervosa patients impairs weight gain and behavioral performance in female mice


    ABSTRACT Anorexia nervosa (AN) results in gut dysbiosis, but whether the dysbiosis contributes to AN-specific pathologies such as poor weight gain and neuropsychiatric abnormalities remains unclear. To address this, germ-free mice were reconstituted with the microbiota of four AN restricting-type patients (gAN mice) and four healthy control individuals (gHC mice). The effects of gut microbes […]

  • Reproducible changes in the gut microbiome suggest a shift in microbial and host metabolism during spaceflight


    ABSTRACT Background Space environment imposes a range of challenges to mammalian physiology and the gut microbiota, and interactions between the two are thought to be important in mammalian health in space. While previous findings have demonstrated a change in the gut microbial community structure during spaceflight, specific environmental factors that alter the gut microbiome and […]

  • Murine Genetic Background has a Stronger Impact on the Composition of the Gut Microbiota than Maternal Inoculation or Exposure to Unlike Exogenous Microbiota


    ABSTRACT The gut microbiota is a complex ecosystem, affected by both environmental factors and host genetics. Here we aim at uncovering the bacterial taxa whose gut persistence is controlled by host genetic variation. We used a murine model based on inbred lines BALB/c and C57BL/6J and their F1 reciprocal hybrids (♀C57BL/6J×♂BALB/c; ♀BALB/c×♂C57BL/6J). To guarantee genetic […]

  • Events
    We maintain a calendar of events and meetings related to the field of Microbiome Research. Check it often for new events and conferences, or submit something for the calendar here.

  • Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice


    Significance Studies using experimental models have indicated that multiple sclerosis (MS)-like disease can be triggered in the gut following interactions of brain autoimmune T lymphocytes with local microbiota.

  • BOOK REVIEW: GNOTOBIOTICS


    Gnotobiotics, edited by Trenton Schoeb and Kathryn Eaton, is invaluable to those developing or managing gnotobiotic facilities.

  • Stress could be just as unhealthy as junk food


    Brigham Young University: We all know that a poor diet is unhealthy, but a new BYU study finds that stress may just as harmful to our bodies as a really bad diet.

  • Infection via mosquito bite alters Zika virus replication kinetics in rhesus macaques


    Abstract For more than three decades it has been recognized that small amounts of vector saliva can significantly alter the infectivity of vector-borne pathogens and subsequent in vivo dynamics.

  • Of Mice, Dirty Mice, and Men: Using Mice To Understand Human Immunology


    Abstract Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans.

  • Microbial Genetic Composition Tunes Host Longevity


    Highlights •Systematic analysis of longevity-promoting microbial genetic variations •Colanic acid as a pro-longevity natural compound effective in different species

  • Learning more about the gut microbiota


    The GMFH editing team recommends these book selections on the topic.

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