The Translational Microbiome Research Forum is an online resource for scientists engaged in translational microbiome research to access current, topical information and to provide a platform to exchange knowledge and ideas. We encourage you to participate by actively using the commenting system, by submitting links, resources, and your original research, and by joining our email list to receive updates when new content is posted.

  • ‘Genetic scalpel’ can manipulate the microbiome, study shows

    The gut microbiome is crucial to health, encompassing bacterial communities that possess a hundred times more genes than the human genome.

  • Virus may lead to celiac disease through disruption of intestinal immune homeostasis

    Celiac disease (CeD) is a complex immune mediated disorder that is triggered by abnormal immune responses to the dietary protein gluten, which is found in grains like wheat, barley, and rye.

  • This lab-made probiotic fights off infections from unfriendly bacteria

    As scientists continue their exploration of the thousands of organisms that live inside our body, a new study is showing just how much one “good” bacteria can be exploited to its host’s advantage.

  • Age-associated Inflammation Drives Macrophage Dysfunction

    Gut microbes are one of the culprits behind age-associated inflammation and premature death in mice, a new study has found. Inflammation increases with age and is a strong risk factor for death in the elderly, but the underlying cause has not been clear.

  • Gut microbes contribute to age-associated inflammation: Mouse study

    Inflammation increases with age and is a strong risk factor for death in the elderly, but the underlying cause has not been clear.

  • Study links gut microbes to age-related inflammation

    New research with mice by McMaster University in Canada suggests gut microbes can lead to age-related inflammation and premature death.

  • Science News Radio Interview: Taking penicillin while pregnant could affect your baby’s brain

    A study on mice suggests that taking the common antibiotic penicillin when pregnant could alter the brain chemistry of your offspring.

  • Autoimmunity Originates in the Gut

    The global prevalence of autoimmune conditions such as type-1 diabetes, rheumatoid arthritis, and celiac disease has increased rapidly over the most recent decades.

  • Getting antibiotics as a baby may have lasting effects on brain, behavior
    Mother giving her baby medication with a pipette.

    Mouse study backs up human observations showing long-term changes.

  • Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens
    download (1)

    Abstract The high susceptibility of neonates to infections has been assumed to be due to immaturity of the immune system, but the mechanism remains unclear.

  • Engineered Regulatory Systems Modulate Gene Expression of Human Commensals in the Gut

    Highlights •We introduce tools for modulating microbiome gene expression inside the gut •Engineered promoters couple gene expression in Bacteroides to a synthetic inducer

  • Urinary and Fecal Metabonomics Study of the Protective Effect of Chaihu-Shu-Gan-San on Antibiotic-Induced Gut Microbiota Dysbiosis in Rats

    Abstract Accumulating evidence suggests that the gut microbiota dysbiosis and their host metabolic phenotype alteration is an important factor in human disease development.

  • Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease

    Viruses compound dietary pathology Reoviruses commonly infect humans and mice asymptomatically. Bouziat et al. found that immune responses to two gut-infecting reoviruses take different paths in mice (see the Perspective by Verdu and Caminero).

  • Intestinal, extra-intestinal and systemic sequelae of Toxoplasma gondii induced acute ileitis in mice harboring a human gut microbiota

    Abstract Background Within seven days following peroral high dose infection with Toxoplasma gondii susceptible conventionally colonized mice develop acute ileitis due to an underlying T helper cell (Th) -1 type immunopathology.

  • Caspase recruitment domain 9, microbiota, and tryptophan metabolism: dangerous liaisons in inflammatory bowel diseases

    Abstract PURPOSE OF REVIEW Inflammatory bowel diseases (IBDs) develop as a result of a combination of genetic predisposition, dysbiosis of the gut microbiota, and environmental influences.

  • Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction
    Fig 1v2 Age Associated inflammation

    Highlights •Age-associated inflammation drives macrophage dysfunction and tissue damage •Mice under germ-free conditions are protected from age-associated inflammation •Co-housing germ-free mice with old, but not young, mice increases age-related inflammation •Age-related microbiota changes can be reversed by reducing TNF levels

  • Starch-enriched diet modulates the glucidic profile in the rat colonic mucosa

    Abstract Purpose The protective function of the intestinal mucosa largely depends on carbohydrate moieties that as a part of glycoproteins and glycolipids form the epithelial glycocalyx or are secreted as mucins.

  • High-fat feeding rather than obesity drives taxonomical and functional changes in the gut microbiota in mice

    Abstract Background It is well known that the microbiota of high-fat (HF) diet-induced obese mice differs from that of lean mice, but to what extent, this difference reflects the obese state or the diet is unclear.

  • The father of the microbiome
    11.29.2016--Dr. Jeffrey Gordon with students in his lab.
James Byard / WUSTL Photos

    By Julia Evangelou Strait: Jeffrey I. Gordon, MD, is expanding our understanding of human health into nonhuman realms, studying the bacteria that take up residence in the gut and help define who we become. Indeed, this research suggests you are what you — and your microbes — eat.

  • A Little History of the Microbiome

    Michael Cardenas: Continuing with my (apparent) theme of dissecting popular science, I’ve decided to talk about a rapidly growing field of study – that of the microbiome.

  • Events
    We maintain a calendar of events and meetings related to the field of Microbiome Research. Check it often for new events and conferences, or submit something for the calendar here.

  • To see the unseen: ‘Microbiomes’ show explores the common ground between arts, science

    At first glance, it may appear that scientists and artists look at the world in different ways, but look again: Careful observation is at the heart of both callings. “Microbiomes: To See the Unseen,” the latest collaboration between the arts and sciences at The Arts Center in Corvallis, takes that observation to a microscopic level:

  • Bill Gates and Ed Yong Talk About Microbes

    Of Microbes and Men You Should Appreciate Germs By Bill Gates Find Out More: gatesnotes

  • Sampling Strategies for Three-Dimensional Spatial Community Structures in IBD Microbiota Research

    Identifying intestinal microbiota is arguably an important task that is performed to determine the pathogenesis of inflammatory bowel diseases (IBD); thus, it is crucial to collect and analyze intestinally-associated microbiota.

  • VIDEO: The World Of Microbes With Dr. B. Brett Finlay
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    In this brief video, Dr. B. Brett Finlay describes the fascinating world of microbes, and tells the story of his discovery of the E-Coli 0157 vaccine:

  • VIDEO: What If You Had A Second Brain?
    images (1)

    AsapScience, stylized as AsapSCIENCE, is a YouTube channel created by Canadian youtubers Mitchell Moffit and Gregory Brown. The channel produces weekly videos that touch on many different topics of science. Check Out Here: AsapSCIENCE

  • Home-Made Cost Effective Preservation Buffer Is a Better Alternative to Commercial Preservation Methods for Microbiome Research

    The investigation of wildlife gastrointestinal microbiomes by next-generation sequencing approaches is a growing field in microbial ecology and conservation.

  • Free Webinar: Precision Medicine – Learning Lessons From the Microbiome

    Summary The influence of gut microbiota on human health has been well documented, particularly in the case of metabolic disorders, such as type 1 and type 2 diabetes.

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