The Translational Microbiome Research Forum is an online resource for scientists engaged in translational microbiome research to access current, topical information and to provide a platform to exchange knowledge and ideas. We encourage you to participate by actively using the commenting system, by submitting links, resources, and your original research, and by joining our email list to receive updates when new content is posted.

  • Mockrobiota: a public resource for microbiome bioinformatics benchmarking

    Abstract Mock communities are an important tool for validating, optimizing, and comparing bioinformatics methods for microbial community analysis. We present mockrobiota, a public resource for sharing, validating, and documenting mock community data resources, available at Github. The materials contained in mockrobiota include dataset and sample metadata, expected composition data, which are annotated based on one […]

  • Gut bacteria influence the birth of new brain cells in mice

    A long course of antibiotics that wipe out gut bacteria disrupts the growth of brain cells in mice – an effect that can be reversed with exercise or probiotics.

  • Immunization with bacteria promotes stress resilience, coping behaviors in mice, CU-Boulder study finds

    njections of the soil bacterium Mycobacterium vaccae (M. vaccae NCTC 11659) promote stress resilience and improve coping behaviors in mice, according to a new study led by the University of Colorado Boulder.

  • New Microbiome Research Tool Offers Potential to Revolutionise Drug Development

    The University of Luxembourg Announces Breakthrough HuMiX Model in Nature Communications The University of Luxembourg today announced the publication of a research article in the internationally renowned scientific journal Nature Communications.

  • The White House Launches the National Microbiome Initiative
    U.S. President Barack Obama looks through a microscope as he tours Bio Tech Facilities at Forsyth Technical Community College in Winston-Salem, North Carolina, December 6, 2010.  REUTERS/Jim Young      (UNITED STATES - Tags: POLITICS EDUCATION) - RTXVGVZ

    Half a billion dollars are being pledged to study the microbes in humans, crops, soils, oceans, and more. Last October, we ran a story titled “Hey Obama, Can We Have a Unified Microbiome Initiative? Yours, the microbiologists.”

  • Tracking strains in the microbiome: insights from metagenomics and models

    Transmission usually refers to the movement of pathogenic organisms. Yet, commensal microbes that inhabit the human body also move between individuals and environments. Surprisingly little is known about the transmission of these endogenous microbes, despite increasing realizations of their importance for human health.

  • Fermentation Festival Leads to Rapid Response System at Center for Microbiome Innovation

    Test case paves the way for clinical applications of microbiome and metabolome data The personalized collections of microorganisms and molecules found in, on and around us — known as our microbiome and metabolome, respectively — are increasingly recognized for their influences on everything from allergies to obesity.

  • Changes in ‘microbiome’ during canine atopic dermatitis could lead to antibiotic-free therapies for human and canine disease

    Results highlight the importance of dogs as a model for human dermatitis PHILADELPHIA – Atopic dermatitis (AD), a chronic inflammatory skin condition and the most common form of eczema, is estimated to afflict as much as 10 percent of the U.S. population, and is much more common now than it was 50 years ago.

  • Micromanaging the microbiome

    In addition to acting inside the cells in which they are made, microRNAs (miRNAs) can be released to act at a distance. New research suggests that miRNAs should be added to the growing list of factors—along with diet, the immune system, and host genetics and physiology—that shape the composition of the gut microbiome.

  • FAQ on Microbiology of Built Environments from the American Academy of Microbiology

    There is a report out from the American Academy of Microbiology that is based on the “Microbiology of the Built Environment” colloquium they hosted in September 2015. The report summary is below: Built environments are the structures that humans create to shelter from the outdoors and provide spaces for living, working, playing, and getting places. […]

  • The Hidden World of Microbiomes

    What are microbiomes and how many do you have in your body? Read the comic or watch the video here: PHD Comics.

  • Micro Size, Macro Opportunity: Looking for New Applications of our Microbiome

    The “microbiome” is a bustling city of diverse and dynamic bacteria, and its potential for helping patients has scientists and researchers excited for the future.

  • Working with Germ-Free Mice

    The volume of published studies employing axenic or germ-free mice increased dramatically over the past 15 years, in part due to growing interest in microbiome research.

  • Episode 05: Micro But Mighty

    Let’s start with a definition: what is the microbiome? Simply put, the microbiome is the collection of microbes (mostly bacteria) that live in and on your body.

  • How to Culture Uncultured Organisms

    Many microorganisms are “unculturable,” or at least not able to grow in known media. Now, a new tool enables researchers to predict what nutrients organisms need to thrive in the lab, eliminating most of the guesswork involved in setting up new cultures.

  • The Mycobiome

    At a workshop held at the National Institutes of Health  (NIH) last September on the role of human microbiota in infectious disease, I was disheartened not to hear a single talk on the fungal community—the mycobiome.

  • How the Immune System Impacts Gut Microbiota Evolution

    In a novel study demonstrating the influence of the immune system on gut bacteria evolution, scientists from the Insitito Gulbenkian de Ciencia (IGC) in Portugal have made a solid case for the use of personalized medicine for immunocompromised patients with intestinal problems.

  • Microbiome & Mice 2016: Advancing Microbiome Research Symposium

    Watch the videos from the recent scientific symposium “Microbiome & Mice 2016: Advancing Microbiome Research”.

  • The 2nd Annual Translational Microbiome Conference

    The 2nd Annual Translational Microbiome Conference (Boston/April 20-21) is rapidly approaching. Registration is still open, but due to the conference’s growing popularity, space is running out.

  • Events
    We maintain a calendar of events and meetings related to the field of Microbiome Research. Check it often for new events and conferences, or submit something for the calendar here.

  • Effects of walnut consumption on colon carcinogenesis and microbial community structure

    Abstract Walnuts are comprised of a complex array of biologically active constituents with individual cancer-protective properties. Here, we assessed the potential benefit of whole walnut consumption in a mouse tumor bioassay using azoxymethane (AOM).

  • Immune response and gut microbial community structure in bumblebees after microbiota transplants

    Abstract Microbial communities are a key component of host health. As the microbiota is initially ‘foreign’ to a host, the host’s immune system should respond to its acquisition. Such variation in the response should relate not only to host genetic background, but also to differences in the beneficial properties of the microbiota.

  • The Impact of Dietary Soy on Gut Microbiome

    Abstract The metabolism of daidzein, a major compound of soy, produces equol in the presence of intestinal bacteria. Equol is more biologically active and its role in human health remains controversial. It has been shown to have links to tumor regression, tumor progression, cardiovascular health and neurologic function.

  • A Pathogen-Selective Antibiotic Minimizes Disturbance to the Microbiome

    Abstract Broad-spectrum antibiotic therapy decimates the gut microbiome resulting in a variety of negative health consequences.

  • Ly6Chi Monocytes Provide a Link between Antibiotic-Induced Changes in Gut Microbiota and Adult Hippocampal Neurogenesis

    Abstract Highlights • Antibiotics decrease neurogenesis and cognitive function • Probiotics or exercise rescues neurogenesis and cognitive function • Ly6Chi monocytes are crucial for brain homeostasis

  • Effect of Dietary Fibers on Cecal Microbiota and Intestinal Tumorigenesis in Azoxymethane Treated A/J Min/+ Mice

    Abstract Foods naturally high in dietary fiber are generally considered to protect against development of colorectal cancer (CRC). However, the intrinsic effect of dietary fiber on intestinal carcinogenesis is unclear.

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