The Translational Microbiome Research Forum is an online resource for scientists engaged in translational microbiome research to access current, topical information and to provide a platform to exchange knowledge and ideas. We encourage you to participate by actively using the commenting system, by submitting links, resources, and your original research, and by joining our email list to receive updates when new content is posted.

  • Cesarean Section Results in Heavier Mouse Pups
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    Vaginal birth leads to changes in the development of offsprings’ microbiomes not seen among mice born via C-section, which researchers suspect might contribute to the weight differences.

  • Scientists Generate 3D Map of Gut Microbiome
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    Scientists have generated a rudimentary map of the human gut microbiome, which shows the spatial organization of different microbial species.

  • Study shows stress could be just as unhealthy as junk food
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    We all know that a poor diet is unhealthy, but a new BYU study finds that stress may just as harmful to our bodies as a really bad diet.

  • Engineering The Microbiome – The Next Frontier
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    Microbial ecology, our understanding of what determines the robustness and community dynamics of microbial consortia, and synthetic biology,

  • Causal link reported between c-section births and increased obesity risk
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    A causal link involving friendly bacteria has been found between C-section births and increased obesity risk.

  • Common acid reflux medications promote chronic liver disease
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    Summary: Approximately 10 percent of Americans take a proton pump inhibitor drug to relieve symptoms of frequent heartburn and acid reflux.

  • Fermented Milk, Probiotics And Yeast Membrane Constituents May Prevent Colorectal Cancer
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    Colorectal cancer (CRC) is the result of a series of histopathological changes starting with the appearance of outbreaks of aberrant crypts (AC) in the colon and generally leading to adenocarcinoma.

  • Do Microbes Trigger Alzheimer’s Disease?
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    The once fringe idea is gaining traction among the scientific community.

  • The Big List Of Prebiotics/Probiotics Companies And Investors
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    Interest in microbiota has reached all areas of human health and disease. As a result, the therapeutic potential of probiotics has expanded.

  • A preliminary examination of gut microbiota, sleep, and cognitive flexibility in healthy older adults
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    Highlights •Results suggest an association between gut microbiota and cognitive flexibility. •Poor sleep precedes lower cognitive flexibility and altered microbiome composition. •Altered microbiome composition may associate poor sleep to adverse cognitive outcomes.

  • Spatial organization of a model 15-member human gut microbiota established in gnotobiotic mice
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    Significance Spatial structure is postulated to have a powerful influence on establishing and sustaining the signaling and metabolic exchanges that define relationships among members of the gut microbiota and host.

  • Interhost dispersal alters microbiome assembly and can overwhelm host innate immunity in an experimental zebrafish model
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    Significance Manipulating the microbial communities associated with animals to improve host health requires a comprehensive understanding of the mechanisms driving microbiome variation, which a strict focus on host-specific factors has been insufficient in providing.

  • Vancomycin and ceftriaxone can damage intestinal microbiota and affect the development of the intestinal tract and immune system to different degrees in neonatal mice
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    Abstract This study aimed to determine how antibiotic-driven intestinal dysbiosis impairs the development and differentiation of the digestive tract and immune organs of host animals.

  • Sleep and the gut microbiome: antibiotic-induced depletion of the gut microbiota reduces nocturnal sleep in mice
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    Abstract Several bacterial cell wall components such as peptidoglycan and muramyl peptide are potent inducers of mammalian slow-wave sleep when exogenously administered to freely behaving animals.

  • Can intestinal microbiota be associated with non-intestinal cancers?
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    Abstract While the role of intestinal microbiota is increasingly recognized in the etiology of digestive cancers, its effects on the development of cancer in other parts of the body have been little studied.

  • Ganoderma lucidum polysaccharides improve insulin sensitivity by regulating inflammatory cytokines and gut microbiota composition in mice
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    Highlights •Ganoderma lucidum polysaccharides (GLP) ameliorated low grade chronic inflammation. •GLP ameliorated non-esterified fatty acid outflux and ectopic lipid accumulation. •GLP improved systemic insulin sensitivity. •GLP changed the composition of gut microbiota.

  • Control of lupus nephritis by changes of gut microbiota
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    Abstract Background Systemic lupus erythematosus, characterized by persistent inflammation, is a complex autoimmune disorder with no known cure.

  • Progress Uncovering the Mysteries of the Human Microbiome
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    This blog is authored by members of the CDD Vault community. CDD Vault is a hosted drug discovery informatics platform that securely manages both private and external biological and chemical data…Nigel R. A. Beeley, Ph.D.:

  • SCITECH | Exploring alternative causes of Alzheimer’s
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    Saishree Badrinarayanan: Microbes and infections might cause Alzheimer’s disease What do Herpes simplex virus type 1 (HSV1), Chlamydia and Syphilis have to do with Alzheimer’s disease?

  • Events
    We maintain a calendar of events and meetings related to the field of Microbiome Research. Check it often for new events and conferences, or submit something for the calendar here.

  • Stress could be just as unhealthy as junk food
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    Brigham Young University: We all know that a poor diet is unhealthy, but a new BYU study finds that stress may just as harmful to our bodies as a really bad diet.

  • Infection via mosquito bite alters Zika virus replication kinetics in rhesus macaques
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    Abstract For more than three decades it has been recognized that small amounts of vector saliva can significantly alter the infectivity of vector-borne pathogens and subsequent in vivo dynamics.

  • Of Mice, Dirty Mice, and Men: Using Mice To Understand Human Immunology
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    Abstract Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans.

  • Microbial Genetic Composition Tunes Host Longevity
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    Highlights •Systematic analysis of longevity-promoting microbial genetic variations •Colanic acid as a pro-longevity natural compound effective in different species

  • Learning more about the gut microbiota
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    The GMFH editing team recommends these book selections on the topic.

  • Effects of iron supplementation on growth, gut microbiota, metabolomics and cognitive development of rat pups
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    Abstract Background Iron deficiency is common during infancy and therefore iron supplementation is recommended.

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