The Translational Microbiome Research Forum is an online resource for scientists engaged in translational microbiome research to access current, topical information and to provide a platform to exchange knowledge and ideas. We encourage you to participate by actively using the commenting system, by submitting events, and by joining our email list to receive updates when new content is posted.

  • Language, numeracy and logic in microbiome science


    To deliver precision therapeutics, microbiome-based medicine will require precision of language, logic and numerical accuracy. Epidemiological lessons of the past suggest that attempts to link almost everything in modern life with the microbiome as a risk factor for disease, without rapprochement with plausible mechanisms, will generate controversy rather than consensus. Read more at Nature Reviews: […]

  • USF Health convenes first Microbiome Joint Workshop with University of Florida


    The University of South Florida and the University of Florida convened a Microbiome Joint Workshop at USF Health on May 28, with research presentations by basic scientists and clinician scientists from both universities. It was an important first step in working together to unravel how different microorganisms living in our guts, on our skin, and […]

  • EU biotech firms unite in pushing for ‘harmonised’ microbiome therapeutics regulation


    The Intestinal Microbiome-based Medicines European Task Group (IMM-ETG) involves Caelus Health, EnteroBiotix, Ferring Pharmaceuticals and Maat Pharma along with Pharmabiotic Research Institute (PRI). “The IMM-ETG has been established to contribute to a harmonised regulatory framework in Europe for the intestinal microbiome products based on the whole ecosystem,” said Dr. Luc Sterkman, CEO of Caelus Health. […]

  • Priorities for the next 10 years of human microbiome research


    Over the past decade, more than US$1.7 billion has been spent on human microbiome research. Major projects are under way in the United States, the European Union, China, Canada, Ireland, South Korea and Japan. This investment has confirmed the importance of the microbiome to human health and development. It is now known, for instance, that […]

  • The Human Microbiome Project expands the toolbox for studying host and microbiome interactions


    Results from three long-term studies following host and microbiome characteristics during pregnancy and preterm birth, inflammatory bowel disease, and prediabetes have expanded our understanding of how humans and microbes interact and the resulting consequences for our health. The studies were funded as part of a second phase of the National Institutes of Health’s Human Microbiome […]

  • Transportation Affects Gut Microbiome of Laboratory Mice


    Experimental controls are at the center of every quality experiment, and understanding the causes of microbiome variability is key to controlling for microbiome-related effects. Researchers that utilize murine models attempt to control for possible microbiome variability by ordering mice from the same vendor, using littermate controls, and employing co-housing strategies1. Given the ongoing research reproducibility […]

  • Cell Press: Cell Host & Microbe


    The Human Microbiome has been a recent area of intense research, rapid progress, and exciting advances. Cell Host & Microbe has published a diverse array of exciting articles related to The Human Microbiome. In this Collection, we present a selection of recent research and review articles on the topic. Read more at Cell Press: Cell […]

  • How Antibiotics Affect Your Microbiome


    The human gut microbiome is a complex, highly-evolved commensal community with an integral role in your response to disease and how well you maintain homeostasis. While commensal bacteria vary from person to person, a person’s specific microbiome should contain the same relative percentage of bacterial species over their lifespan. The balance of this community can […]

  • Do you know what’s in your water?


    Most researchers know the pain of trying and failing to replicate a published experiment. This can result from something as simple as a poorly written methods section, in which important experimental details have been omitted. Barnett and Gibson recently called out the importance of an in vivo experimental detail that is commonly left out and […]

  • Heterochronic faecal transplantation boosts gut germinal centres in aged mice


    DISCUSSION The composition of the commensal gut microbiota changes with age, which is linked with an increase in age-associated morbidities such as frailty2,4 and intestinal disorders30, but the cause of this shift in the gut microbial composition is unknown. Here we sought to determine whether there is a causal link between age-dependent changes in the […]

  • Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice


    ABSTRACT Autism spectrum disorder (ASD) manifests as alterations in complex human behaviors including social communication and stereotypies. In addition to genetic risks, the gut microbiome differs between typically developing (TD) and ASD individuals, though it remains unclear whether the microbiome contributes to symptoms. We transplanted gut microbiota from human donors with ASD or TD controls […]

  • Loss of function dysbiosis associated with antibiotics and high fat, high sugar diet


    ABSTRACT The incidence of urinary stone disease (USD) has increased four-fold in 50 years. Oxalate, which is degraded exclusively by gut bacteria, is an important constituent in 80% of urinary stones. We quantified the effects of antibiotics and a high fat/high sugar (HFHS) diet on the microbial metabolism of oxalate in the gut. High and […]

  • Toll‐like receptor 2 and toll‐like receptor 4 responses regulate neutrophil infiltration into the junctional epithelium and significantly contribute to the composition of the oral microbiota


    ABSTRACT BACKGROUND Oral gingival tissue, especially the junctional epithelium (JE), is constantly exposed to sub‐gingival plaque. A key component of gingival health is the regulation of the number of neutrophils that migrate into the gingival crevice to counteract its harmful effects. This report investigates the contribution of innate defense receptors, Toll‐like receptor 2 (TLR), TLR4 […]

  • CD1d Modulates Colonic Inflammation in NOD2−/− Mice by Altering the Intestinal Microbial Composition Comprising Acetatifactor muris


    ABSTRACT AIMS NOD2 and CD1d play a key role in innate immunity by recognizing conserved molecular patterns of pathogens. While NOD2−/− and CD1d−/− mice display structural and functional alterations in Paneth cells, animal studies have reported no impact of NOD2 or CD1d deficiency on experimental colitis. NOD2 mutations increase the susceptibility to inflammatory bowel diseases […]

  • Does MHC heterozygosity influence microbiota form and function?


    ABSTRACT MHC molecules are essential for the adaptive immune response, and they are the most polymorphic genetic loci in vertebrates. Extreme genetic variation at these loci is paradoxical given their central importance to host health. Classic models of MHC gene evolution center on antagonistic host-pathogen interactions to promote gene diversification and allelic diversity in host […]

  • Absence of gut microbiota during early life affects anxiolytic Behaviors and monoamine neurotransmitters system in the hippocampal of mice


    ABSTRACT The gut microbiome is composed of an enormous number of microorganisms, generally regarded as commensal bacteria. Resident gut bacteria are an important contributor to health and significant evidence suggests that the presence of healthy and diverse gut microbiota is important for normal cognitive and emotional processing. Here we measured the expression of monoamine neurotransmitter-related […]

  • Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes


    ABSTRACT We demonstrated that an antibiotic cocktail (ABX)-perturbed gut microbiome is associated with reduced amyloid-β (Aβ) plaque pathology and astrogliosis in the male amyloid precursor protein (APP)SWE/presenilin 1 (PS1)ΔE9 transgenic model of Aβ amyloidosis. We now show that in an independent, aggressive APPSWE/PS1L166P (APPPS1-21) mouse model of Aβ amyloidosis, an ABX-perturbed gut microbiome is associated […]

  • A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip


    ABSTRACT The diverse bacterial populations that comprise the commensal microbiome of the human intestine play a central role in health and disease. A method that sustains complex microbial communities in direct contact with living human intestinal cells and their overlying mucus layer in vitro would thus enable the investigation of host–microbiome interactions. Here, we show […]

  • Events
    We maintain a calendar of events and meetings related to the field of Microbiome Research. Check it often for new events and conferences, or submit something for the calendar here.

  • Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice


    Significance Studies using experimental models have indicated that multiple sclerosis (MS)-like disease can be triggered in the gut following interactions of brain autoimmune T lymphocytes with local microbiota.

  • BOOK REVIEW: GNOTOBIOTICS


    Gnotobiotics, edited by Trenton Schoeb and Kathryn Eaton, is invaluable to those developing or managing gnotobiotic facilities.

  • Stress could be just as unhealthy as junk food


    Brigham Young University: We all know that a poor diet is unhealthy, but a new BYU study finds that stress may just as harmful to our bodies as a really bad diet.

  • Infection via mosquito bite alters Zika virus replication kinetics in rhesus macaques


    Abstract For more than three decades it has been recognized that small amounts of vector saliva can significantly alter the infectivity of vector-borne pathogens and subsequent in vivo dynamics.

  • Of Mice, Dirty Mice, and Men: Using Mice To Understand Human Immunology


    Abstract Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans.

  • Microbial Genetic Composition Tunes Host Longevity


    Highlights •Systematic analysis of longevity-promoting microbial genetic variations •Colanic acid as a pro-longevity natural compound effective in different species

  • Learning more about the gut microbiota


    The GMFH editing team recommends these book selections on the topic.

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