Heading off on vacation? Pack your beach bag with one of these 10 cutting-edge scientific books to keep your mind active this summer: Pandora’s Lab: Seven Stories of Science Gone Wrong, by Paul A. Offit MD The Hidden Half of Nature: The Microbial Roots of Life and Health, by David R. Montgomery and Anne Bikle […]
An increased interest in studies involving the microbiota requires animal models that appropriately mimic the extremely complex normal gut microbiota. Differences in rodent models can have a negative impact on a study’s reproducibility. On July 4, 2018, researchers at the University of Missouri, University of California, Davis, and University of North Carolina at Chapel Hill […]
While developing a novel gnotobiotic housing strategy, researchers on the Nested Isolation project discovered a cyclical bias in the microbiome composition of animals in SPF cages. These changes in microbiota could influence phenotype and confound study endpoints, with implications for the reproducibility of some gnotobiotic research. How can you best identify and control for cyclical […]
Scientists have found that deleting a single gene in a particular strain of gut bacteria causes changes in metabolism and reduced weight gain in mice, according to a study in the journal eLife. The research provides an important step towards understanding how the microbiome – the bacteria that live in our body – affects metabolism. […]
A mysterious, complex and largely unknown universe exists within and on you. Every day, as you go about your routine, colossal quantities of microbes that form your unique microbiome are aiding or obstructing your functions. What role can this universe, the human microbiome, play in preventing disease and treating illness? This question has spurred unique […]
Watch Taconic Biosciences’ new webinar, Nested Isolation: A Low-Cost Housing Strategy to Boost Microbiome Research Capabilities, to learn how Nested isolation works. Nested isolation – or NesTiso – is a technique that not only delivers the same results as a full gnotobiotic core, but with commonly accessible equipment and dramatically improved usability. Presented by Alexander […]
Download Taconic Biosciences’ new infographic, Translational Microbiome at a Glance, for valuable insights into the translational aspects of microbiome research. Intended for those just beginning their work, Translational Microbiome at a Glance covers critical introductory subjects such as: The six factors that shape the mouse microbiome — and study endpoints Disease associations that can impact […]
A myriad of factors can influence the gut microbiota composition of laboratory rats and mice: diet, stress, circadian rhythm, vendor source, how they are housed, and more. Since different gut microbiota compositions can elicit different phenotypes under otherwise similar experimental conditions, understanding what shapes the rodent microbiome is becoming increasingly important for researchers. Husbandry-Induced Microbiome […]
Clostridium difficile is a significant source of infectious disease death in the United States, and C. difficile infection can be difficult to treat. Many researchers are focusing on new therapies for this major health problem, including clinical use of fecal microbiota transplantation. Dietary manipulations are another avenue of study. Researchers at the Stanford University School […]
ABSTRACT Glaucoma is the most prevalent neurodegenerative disease and a leading cause of blindness worldwide. The mechanisms causing glaucomatous neurodegeneration are not fully understood. Here we show, using mice deficient in T and/or B cells and adoptive cell transfer, that transient elevation of intraocular pressure (IOP) is sufficient to induce T-cell infiltration into the retina. […]
ABSTRACT Alterations in enteric microbiota are associated with several highly prevalent immune-mediated and metabolic diseases1,2,3, and experiments involving faecal transplants have indicated that such alterations have a causal role in at least some such conditions4,5,6. The postnatal period is particularly critical for the development of microbiota composition, host–microbe interactions and immune homeostasis7,8,9. However, the underlying […]
ABSTRACT Objective The consumption of fruits is strongly associated with better health and higher bacterial diversity in the gut microbiota (GM). Camu camu (Myrciaria dubia) is an Amazonian fruit with a unique phytochemical profile, strong antioxidant potential and purported anti-inflammatory potential. Design By using metabolic tests coupled with 16S rRNA gene-based taxonomic profiling and faecal […]
ABSTRACT Vitamin D has been suggested as a possible adjunctive treatment to ameliorate disease severity in human inflammatory bowel disease. In this study, the effects of diets containing high (D++, 10,000 IU/kg), moderate (D+, 2,280 IU/kg) or no vitamin D (D−) on the severity of dextran sodium sulphate (DSS) colitis in female C57Bl/6 mice were investigated. […]
ABSTRACT Despite the tremendous biological activity of polysaccharides from the mushroom Dictyophora indusiata, its role in the restoration of gut microbiota has not yet been explored. The present study aimed to investigate whether D. indusiata polysaccharide (DIP) could modulate the recovery of gut microbiota composition and intestinal barrier function after broad-spectrum antibiotic-driven dysbiosis. Alteration and […]
ABSTRACT Considering the increasing list of diseases linked to the commensal microbiota, experimental studies of host–microbe interactions are of growing interest. Axenic and differently colonized animal models are inalienable tools to study these interactions. Factors, such as host genetics, diet, antibiotics and litter affect microbiota composition and can be confounding factors in many experimental settings. […]
ABSTRACT The intestine is key for nutrient absorption and for interactions between the microbiota and its host. Therefore, the intestinal response to caloric restriction (CR) is thought to be more complex than that of any other organ. Submitting mice to 25% CR during 14 days induced a polarization of duodenum mucosa cell gene expression characterised […]
ABSTRACT High-fat (HF) diets are thought to disrupt the profile of the gut microbiota in a manner that may contribute to the neuroinflammation and neurobehavioral changes observed in obesity. Accordingly, we hypothesize that by preventing HF-diet induced dysbiosis it is possible to prevent neuroinflammation and the consequent neurological disorders. Anthocyanins are flavonoids found in berries […]
ABSTRACT Bacteria that are highly virulent, expressing high infectivity, and able to survive nebulization, pose great risk to the human population. One of these is Francisella tularensis, the etiological agent of tularemia. F. tularensis is a subject of intense scientific interest due to the fact that vaccines for its immunoprophylaxis in humans are not yet […]
Significance Studies using experimental models have indicated that multiple sclerosis (MS)-like disease can be triggered in the gut following interactions of brain autoimmune T lymphocytes with local microbiota.
Gnotobiotics, edited by Trenton Schoeb and Kathryn Eaton, is invaluable to those developing or managing gnotobiotic facilities.
Brigham Young University: We all know that a poor diet is unhealthy, but a new BYU study finds that stress may just as harmful to our bodies as a really bad diet.
Abstract For more than three decades it has been recognized that small amounts of vector saliva can significantly alter the infectivity of vector-borne pathogens and subsequent in vivo dynamics.
Abstract Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans.
Highlights •Systematic analysis of longevity-promoting microbial genetic variations •Colanic acid as a pro-longevity natural compound effective in different species