The Translational Microbiome Research Forum is an online resource for scientists engaged in translational microbiome research to access current, topical information and to provide a platform to exchange knowledge and ideas. We encourage you to participate by actively using the commenting system, by submitting links, resources, and your original research, and by joining our email list to receive updates when new content is posted.

  • The Microbiome’s Role in Precision Medicine
    e-coli-bacteria


    Inside the human body lives a complex community of microorganisms, bacteria, viruses and fungi known as the microbiome. Found primarily in the intestine, the microbiome plays an integral role in human health and wellness.

  • Genes, early environment sculpt the gut microbiome
    The nuclei of mouse epithelial cells (red) and the microbes (green) in the mouse intestine are visible.


    Genetics and birthplace have a big effect on the make-up of the microbial community in the gut, according to research published Nov. 28 in the journal Nature Microbiology.

  • Stress-induced changes in maternal gut could negatively impact offspring for life
    14387196-albino-female-mouse-with-nine-day-old-pups-stock-photo-mouse


    Mouse study finds potential link between microbiome and anxiety, learning difficulty

  • Gut Microbes Linked to Neurodegenerative Disease
    Gut microbes can initiate activation of microglia, which leads to the neuroinflammation that is characteristic of Parkinson’s disease.
CALTECH/S. MAZMANIAN LAB


    CALTECH/S. MAZMANIAN LAB Many people with Parkinson’s disease have digestive symptoms like constipation years before they have neurological symptoms, and scientists have found differences in the gut microbiome compositions of patients with Parkinson’s disease and healthy controls.

  • Skin bacterium releases enzyme that may protect against damage and disease
    p-acnes


    A new study shows how a bacterium that is often abundant on human skin secretes an enzyme with antioxidant properties that not only helps the microorganism itself survive, but it may also protect us against damage and disease.

  • Gut microbiota may play important role in influencing onset of blinding wet AMD
    sn-eyedisease


    Age-related Macular Degeneration (AMD) is the leading cause of irreversible blindness in the industrialized world, affecting over 10 million individuals in North America.

  • Scientists discover important link between immune system, gut bacteria and glucose metabolism
    akkermansia


    Researchers at Oregon State University and other institutions have discovered an important link between the immune system, gut bacteria and glucose metabolism — a “cross-talk” and interaction that can lead to type 2 diabetes and metabolic syndrome when not functioning correctly.

  • Predatory Bacteria Can Cannibalize Drug-Resistant Bugs
    predatory-bacteria-can-cannibalize-drug-resistant-bugs


    A new study shows that a strain of bacteria was able to kill pneumonia inside the lungs of sick rats.

  • Predatory bacteria offer potential solution to drug resistance problem
    predatorybac


    For the first time ever, scientists have used predatory bacteria to kill pneumonia in a rat animal model.

  • Gutsy: The Gut Microbiome Card Game
    micro_dude


    Each of us has a community of microbes that lives in our digestive system. Scientists call this community our gut microbiome. It plays many important roles in our bodies, like helping to digest food, regulating our immune system, preventing diseases, and even affecting our appetites and our emotions.

  • “You are not alone: The microbiome.” Play the game!
    screen-shot-2014-03-19-at-11-18-07-am


    pgEd’s newest quiz, “You Are Not Alone: The Microbiome” is live and ready for people to make their way through the questions, learn about the bacteria that are an essential part of our bodies

  • Podcast: Yale University Microbiome Episode 3
    podcast-image


    What’s next for microbiome research? In the third and final episode on the microbiome, we are joined by Dr. Camille Konopnicki, a post-doctoral fellow in the lab of Dr. Andrew Goodman

  • Podcast: Yale University Microbiome Episode 2
    podcast-image


    What has the microbiome taught us? In the second episode on the microbiome, we are joined by Yale rheumatologist and assistant professor of Immunobiology and Medicine, Dr. Martin Kriegel to discuss articles published in our issue

  • Podcast: Yale University Microbiome Episode 1
    podcast-image


    Want to learn more about the microbiome? In the first episode of three on the microbiome, the focus topic for the September 2016 issue of the Yale Journal of Biology and Medicine, we will be discussing the history of the field, current techniques used in microbiome research, and how the microbiome influences our health.

  • VIDEO: Gut microbiome key influencer of weight, metabolic syndrome
    video


    NEW ORLEANS — In this video exclusive, C. Ronald Kahn, MD, chief academic officer and senior investigator at Joslin Diabetes Center and the Mary K. Iacocca professor of medicine at Harvard Medical School, discusses the role of the gut microbiome in relation to genes and environment in determining body composition and metabolic health.

  • GUT CHECK: THE MICROBIOME GAME
    gut-check-postcard-for-web


    Gut Check is a scientific, strategic and competitive board game designed to be enjoyable for scientists, students and game enthusiasts alike. The game consists of several card types, including beneficial, opportunistic and pathogenic microbes, infections and events.

  • Metabolomics – A Key Technology for Microbiome Research
    Metabolic Process Microbiome


    Bacteria have co-evolved with us for thousands of years. We now understand that they are closely linked to many aspects of health. But, in most cases, the complex influences of microbiota on our health is not yet functionally understood.

  • FAQ on Microbiology of Built Environments from the American Academy of Microbiology
    Screenshot-2016-05-17-10.36.08-684x1024


    There is a report out from the American Academy of Microbiology that is based on the “Microbiology of the Built Environment” colloquium they hosted in September 2015.

  • MICROBIOME AFFECTS SEVERITY IN MOUSE MODEL OF MALARIA
    malaria-mouse


    Insight from Megan M. MacBride, PhD: Malaria is a serious global health hazard, with 214 million new cases worldwide in 2015 according to the World Health Organization.

  • Arrowhead Publishers Announces the Preliminary Speaker Faculty for 3rd Annual Translational Microbiome Conference
    3rd-annual-microbiome-conf


    Arrowhead Publishers has announced the preliminary speaking faculty for the 3rd Annual Translational Microbiome Conference. This conference, taking place April 11-13, 2017 in Boston, MA,

  • Events
    We maintain a calendar of events and meetings related to the field of Microbiome Research. Check it often for new events and conferences, or submit something for the calendar here.

  • Gut microbiota induce IGF-1 and promote bone formation and growth
    bone-978054_960_720


    Significance New interventions are needed to improve bone health and reduce the risk for osteoporosis and fracture. Dysbiosis is increasingly linked to metabolic abnormalities, although the effect of the microbiota on skeletal health is poorly understood.

  • Diet-Microbiota Interactions Mediate Global Epigenetic Programming in Multiple Host Tissues
    GraphicalAbstract


    Highlights •Gut microbiota alter host histone acetylation and methylation in multiple tissues •Western diet suppresses microbiota-driven SCFA production and chromatin effects •SCFAs recapitulate microbiota-driven chromatin and transcriptional effects

  • Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney
    graphical abstract Kopie


    Highlights •Pathogenic TH17 cells migrate from the gut to the kidney in autoimmunity •TH17 cells egress the intestine in a S1PR1-dependent manner in glomerulonephritis •Targeting microbiota-induced TH17 cells ameliorates extraintestinal TH17 responses

  • Persistent microbiome alterations modulate the rate of post-dieting weight regain
    flavonoid


    Abstract In tackling the obesity pandemic, significant efforts are devoted to the development of effective weight reduction strategies, yet many dieting individuals fail to maintain a long-term weight reduction, and instead undergo excessive weight regain cycles.

  • Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease
    fx1-1


    Highlights •Gut microbes promote α-synuclein-mediated motor deficits and brain pathology •Depletion of gut bacteria reduces microglia activation •SCFAs modulate microglia and enhance PD pathophysiology •Human gut microbiota from PD patients induce enhanced motor dysfunction in mice

  • Lactobacillus salivarius Isolated from Patients with Rheumatoid Arthritis Suppresses Collagen-Induced Arthritis and Increases Treg Frequency in Mice
    lactobacillus


    Abstract Previously, we demonstrated that Lactobacillus salivarius was more abundant in patients with rheumatoid arthritis (RA), an inflammatory autoimmune disease wherein the gut microbiota is altered, than in healthy individuals. However, the effect of L. salivarius in RA is unclear.

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