The Translational Microbiome Research Forum is an online resource for scientists engaged in translational microbiome research to access current, topical information and to provide a platform to exchange knowledge and ideas. We encourage you to participate by actively using the commenting system, by submitting events, and by joining our email list to receive updates when new content is posted.

  • Landmark paper calls for need to develop the world’s microbiome biobanking infrastructure


    A team of scientists led by CABI’s Dr. Matthew Ryan has outlined a series of challenges and opportunities presented in a necessary review of how microbiomes—biological communities including bacteria, archaea, fungi, algae, protists and viruses—can be ‘banked’ and preserved for generations to come. The researchers, who call for a prioritized list of what should be […]

  • On-Demand Webinar: Breed Vs. Buy: What’s The Right Choice For Your Lab?


    How do you determine whether to buy laboratory rodents from a commercial vendor or to produce them with an in-house breeding colony? This is dependent on your lab’s specific situation and research needs. Check out this webinar at your leisure to hear from a panel of experts at Taconic Biosciences who will discuss the critical […]

  • On-Demand Webinar: Genetically Engineered Mouse Colitis Models for Preclinical Drug Development


    Genetically engineered mouse colitis models are increasing the flexibility and predictive validity of preclinical colitis models in inflammatory bowel disease (IBD) research. These powerful tools are increasingly supplementing or replacing traditional chemically induced models (e.g. DSS- or TNBS-induced colitis), and offer important translational and mechanistic insights in IBD drug development. View this webinar to learn […]

  • Update on the Upcoming “Virtual” Translational Microbiome Conference


    The 6th Annual Translational Microbiome Conference is carrying on as a “VIRTUAL” event this year on April 21st through the 24th. We’ve recently adjusted our agenda to accommodate a virtual event. Here are a few details regarding this event in case you’d like to join us: 4 days of learning via our virtual conference platform […]

  • Webinar Q&A — Microbiological Monitoring of Germ-Free and Gnotobiotic Colonies


    Dr. Paula Roesch recently presented a webinar on microbiological monitoring of germ-free and gnotobiotic colonies. Taconic Biosciences has decades of experience in this area and Dr. Roesch presented a thorough look at all aspects of the process, starting from tools and approaches to process validation and monitoring and moving into isolator monitoring techniques. She even […]

  • On-Demand Webinar: Microbiological Monitoring of Germ-free and Gnotobiotic Colonies


    In order to maintain germ-free colonies, researchers must implement specialized techniques and husbandry requirements not needed in standard vivariums. This is critical to prevent contamination within a gnotobiotic facility. Download this webinar to learn about appropriate validation of supply sterilization and recommended monitoring techniques for germ-free and gnotobiotic isolators. By watching you can learn: Autoclave, […]

  • Webinar Q&A — Controlling the Macroenvironment: A Novel Approach to Germ-free Derivations


    Dr. Cristina Weiner recently presented a webinar featuring a novel approach to germ-free derivations. She discussed the importance of understanding baseline performance and making incremental process improvements as well as how Taconic Biosciences developed and implemented a new facility design which supports improved germ-free derivation success. Q: You stated during the presentation that, on balance, […]

  • Time For Better Microbiome Research


    The microbiome needs no introduction – it has been several years since you could pick up a biomedical research journal and not run into an article on possible connections of human gut bacteria and disease. There were thousands of such papers last year alone. But it’s a very hard field to work in. You can […]

  • On-Demand Webinar: Controlling the Macroenvironment – A Novel Approach to Germ-free Derivations


    Download this webinar to learn a novel approach to germ-free derivations outside of the limitations of an isolator — an approach focused on control of the macroenvironment. Dr. Cristina Weiner, VMD, MS, DACLAM, presents and shares how applying cleanroom technology to gnotobiotic animal husbandry has resulted in the improved success of germ-free derivations. By watching […]

  • In vivo antiviral host transcriptional response to SARS-CoV-2 by viral load, sex, and age


    Abstract Despite limited genomic diversity, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has shown a wide range of clinical manifestations in different patient populations. The mechanisms behind these host differences are still unclear. Here, we examined host response gene expression across infection status, viral load, age, and sex among shotgun RNA sequencing profiles of nasopharyngeal […]

  • Microbial metabolite protects against infection


    Abstract Intestinal dysbiosis is associated with an increased susceptibility to disseminated bacterial infections and sepsis. Kupffer cells, the resident macrophages of the liver that reside within the hepatic vasculature, protect the organ from pathogens and are the first liver cells to come into contact with the blood that is delivered directly to this organ from […]

  • Gut microorganisms act together to exacerbate inflammation in spinal cords


    Abstract Accumulating evidence indicates that gut microorganisms have a pathogenic role in autoimmune diseases, including in multiple sclerosis1. Studies of experimental autoimmune encephalomyelitis (an animal model of multiple sclerosis)2,3, as well as human studies4,5,6, have implicated gut microorganisms in the development or severity of multiple sclerosis. However, it remains unclear how gut microorganisms act on […]

  • Glycan cross-feeding supports mutualism between Fusobacterium and the vaginal microbiota


    Abstract Women with bacterial vaginosis (BV), an imbalance of the vaginal microbiome, are more likely to be colonized by potential pathogens such as Fusobacterium nucleatum, a bacterium linked with intrauterine infection and preterm birth. However, the conditions and mechanisms supporting pathogen colonization during vaginal dysbiosis remain obscure. We demonstrate that sialidase activity, a diagnostic feature […]

  • Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy


    Abstract Several species of intestinal bacteria have been associated with enhanced efficacy of checkpoint blockade immunotherapy, but the underlying mechanisms by which the microbiome enhances anti-tumor immunity is unclear. Here, we isolated three bacterial species, including Bifidobacterium pseudolongum, Lactobacillus johnsonii and Olsenella species, that significantly enhanced efficacy of immune checkpoint inhibitors in four mouse models […]

  • Lung and gut microbiota are altered by hyperoxia and contribute to oxygen-induced lung injury in mice


    Abstract Inhaled oxygen, although commonly administered to patients with respiratory disease, causes severe lung injury in animals and is associated with poor clinical outcomes in humans. The relationship between hyperoxia, lung and gut microbiota, and lung injury is unknown. Here, we show that hyperoxia conferred a selective relative growth advantage on oxygen-tolerant respiratory microbial species […]

  • Microbiota-derived metabolite promotes HDAC3 activity in the gut


    Abstract The coevolution of mammalian hosts and their beneficial commensal microbes has led to development of a symbiotic host-microbiota relationship. Epigenetic machinery permits mammalian cells to integrate environmental signals, however, how these pathways are finely tuned by diverse cues from commensal bacteria is not well understood. Here, we reveal a highly selective pathway through which […]

  • Colonization of Germ-free Transgenic Mice with Genotyped Helicobacter pylori Strains from a Case-Control Study of Gastric Cancer Reveals a Correlation between Host Responses and HsdS Components of Type I Restriction-Modification Systems


    Abstract Helicobacter pylori infects the stomachs of half of all humans. It has a relatively benign relationship with most hosts but produces severe pathology, including gastric cancer, in others. Identifying the relative contributions of host, microbial, and environmental factors to the outcome of infection has been challenging. Here we describe one approach for identifying microbial […]

  • Neonatal Exposure to Commensal-Bacteria-Derived Antigens Directs Polysaccharide-Specific B-1 B Cell Repertoire Development


    Summary B-1 B cells derive from a developmental program distinct from that of conventional B cells, through B cell receptor (BCR)-dependent positive selection of fetally derived precursors. Here, we used direct labeling of B cells reactive with the N-acetyl-D-glucosamine (GlcNAc)-containing Lancefield group A carbohydrate of Streptococcus pyogenes to study the effects of bacterial antigens on […]

  • Events
    We maintain a calendar of events and meetings related to the field of Microbiome Research. Check it often for new events and conferences, or submit something for the calendar here.

  • Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice


    Significance Studies using experimental models have indicated that multiple sclerosis (MS)-like disease can be triggered in the gut following interactions of brain autoimmune T lymphocytes with local microbiota.

  • BOOK REVIEW: GNOTOBIOTICS


    Gnotobiotics, edited by Trenton Schoeb and Kathryn Eaton, is invaluable to those developing or managing gnotobiotic facilities.

  • Stress could be just as unhealthy as junk food


    Brigham Young University: We all know that a poor diet is unhealthy, but a new BYU study finds that stress may just as harmful to our bodies as a really bad diet.

  • Infection via mosquito bite alters Zika virus replication kinetics in rhesus macaques


    Abstract For more than three decades it has been recognized that small amounts of vector saliva can significantly alter the infectivity of vector-borne pathogens and subsequent in vivo dynamics.

  • Of Mice, Dirty Mice, and Men: Using Mice To Understand Human Immunology


    Abstract Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans.

  • Microbial Genetic Composition Tunes Host Longevity


    Highlights •Systematic analysis of longevity-promoting microbial genetic variations •Colanic acid as a pro-longevity natural compound effective in different species

  • Learning more about the gut microbiota


    The GMFH editing team recommends these book selections on the topic.

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