The Translational Microbiome Research Forum is an online resource for scientists engaged in translational microbiome research to access current, topical information and to provide a platform to exchange knowledge and ideas. We encourage you to participate by actively using the commenting system, by submitting events, and by joining our email list to receive updates when new content is posted.

  • Seasonal Cycling in the Gut Microbiome of the Hadza Hunter-gatherers of Tanzania


    Researchers from Stanford University published a paper in Science titled “Seasonal cycling in the gut microbiome of the Hadza hunter-gatherers of Tanzania” which examines the relationship between diet, seasons, and the microbiome. The authors performed a longitudinal study on 350 stool samples collected throughout a year and a half and found that the microbial population […]

  • 2019 Microbiome Conferences


    Are you looking for a microbiome conference or workshop? Many 2019 conferences are outlined on our event’s page with differing agendas and meetings in the U.S., Europe, and Asia, these educational summits provide an opportunity to network and meet your peers. Here are the first few microbiome conferences of next year: Phage Futures Congress The […]

  • Nature Biotechnology Publication: Translating microbiome futures


    The publication of Translating microbiome futures is the culmination of more than a year’s work by Gaspar Taroncher-Oldenberg, Consultant in Residence at Global Engage and Susan Jones, Senior Editor at Nature Biotechnology. Together they spoke with close to 150 key opinion leaders in microbiome R&D, venture capital, and regulatory agencies. Then on May 23, 2018, […]

  • Mouse Microbiomes Are Mostly Inherited

    A mouse’s gut microbiome is, largely speaking, inherited and alters very little throughout multiple generations, according to a long-term study of caged wild mice published in Science today (October 25). While this vertical transmission predominates in the given experimental setup, the study also reveals that certain genera of bacteria could spread horizontally from cage to […]

  • QIAGEN announces winners of 2018 Microbiome Awards competition

    Two extraordinary young scientists honored with prizes and more than $100,000 in support for research into the impacts of microbial communities on human health Hilden, Germany, and Germantown, Maryland, October 17, 2018 – QIAGEN today announced the winners of its fifth annual 2018 Microbiome Awards, a competition for outstanding researchers working on diverse aspects of […]

  • Housing Systems for Rodents Used in Microbiome Research


    Gnotobiotic technology in laboratory animal science is the processes and systems employed for maintaining gnotobiotic and germfree (germfree) research animals. Through sterilization of feed and other husbandry supplies, and by housing in systems that completely protect the animals from the surrounding environment and human caretakers, the intent is to create and maintain animal models with […]

  • uBiome Launches Innovation Challenge to Advance Microbiome Clinical Outcomes Research

    Submissions to the uBiome Clinical Outcomes in Microbial Genomics Innovation Challenge are now open, welcoming applications from healthcare providers, students, trainees, and researchers worldwide. Winning proposals will receive grants which include access to uBiome’s clinical testing kits, as well as microbiome sequencing and bioinformatics services. “uBiome is thrilled to further expand our collaborations in the […]

  • Webinar Q&A — Cyclical Bias


    In a recent webinar, Dr. Alexander Rodriguez-Palacios of Case Western Reserve University School of Medicine discussed a confounding influence on many common microbiome study endpoints uncovered in studies using the NesTiso system. The NesTiso system has been described in a previous publication1 and examined in an on-demand webinar. There were several outstanding questions submitted by […]

  • Bringing order to the ‘wild frontier’ of microbiome medicine


    I never thought I’d someday write the sentence, “I really enjoyed that FDA meeting.” But here I am doing just that. The topic of the meeting — regulatory implications of an emerging class of medicines to promote health by modulating the teeming microbial ecosystems that live inside each of us — may not sound like […]

  • Insights into a Possible Mechanism Underlying the Connection of Carbendazim-Induced Lipid Metabolism Disorder and Gut Microbiota Dysbiosis in Mice


    ABSTRACT Carbendazim (CBZ), a systemic, broad-spectrum benzimidazole fungicide, is widely used to control fungal diseases and has been regarded as an endocrine disruptor that causes mammalian toxicity in different target organs. Here, we discovered that chronic administrations of CBZ at 0.2, 1, and 5 mg/kg body weight for 14 weeks not only changed the composition of gut […]

  • General Anesthesia Alters the Diversity and Composition of the Intestinal Microbiota in Mice

    ABSTRACT Dysbiosis of the intestinal microbiota has been shown to result in altered immune responses and increased susceptibility to infection; as such, the state of the intestinal microbiome may have profound implications in the perioperative setting. In this first-in-class study, we used 16s ribosomal RNA sequencing and analysis in a mouse model of general anesthesia […]

  • Cesarean Section Induces Microbiota-Regulated Immune Disturbances in C57BL/6 Mice

    ABSTRACT Epidemiological studies have shown that children born by cesarean section (CS) are at higher risk of developing chronic inflammatory diseases, and it has been suggested that a skewed gut microbial colonization process early in life and altered priming of the immune system are causative. The aim of this study was to clarify whether impaired […]

  • On the role of corticosterone in behavioral disorders, microbiota composition alteration and neuroimmune response in adult male mice subjected to maternal separation stress


    ABSTRACT Experiencing psychosocial adversities in early life such as maternal seperation (MS) increases the risk of psychiatric disorders. Immune-inflammatory responses have imperative roles in the pathophysiology of psychiatric disorders. MS relatively changes the composition of intestinal microbiota leading to an overactivation of the hypothalamic–pituitary–adrenal (HPA) axis, and subsequently increases the corticosterone level. In this study, […]

  • Impact of commensal flora on periodontal immune response to lipopolysaccharide

    ABSTRACT 1 Background Commensal flora are involved in the appropriate development of the mature immune system. However, it is unclear how commensal flora contribute to immune responses against periodontal pathogens, including the response to lipopolysaccharide (LPS). The purpose of this study was to evaluate the expression of immune responses after topical application of LPS in […]

  • A prostate derived commensal Staphylococcus epidermidis strain prevents and ameliorates induction of chronic prostatitis by UPEC infection


    ABSTRACT Chronic prostatitis/Chronic pelvic pain syndrome (CP/CPPS) is a common syndrome with limited therapies and an unknown etiology. Previously, our laboratory has defined a potential role for pathogenic infection in disease onset. Intra-urethral infection with a uropathogenic Escherichia coli strain isolated from a CP/CPPS patient, CP1, induces prostatic inflammation and tactile allodynia in mice. We […]

  • Generation of orthotopically functional salivary gland from embryonic stem cells


    ABSTRACT Organoids generated from pluripotent stem cells are used in the development of organ replacement regenerative therapy by recapitulating the process of organogenesis. These processes are strictly regulated by morphogen signalling and transcriptional networks. However, the precise transcription factors involved in the organogenesis of exocrine glands, including salivary glands, remain unknown. Here, we identify a […]

  • The Microbial Metabolite Butyrate Stimulates Bone Formation via T Regulatory Cell-Mediated Regulation of WNT10B Expression


    SUMMARY Nutritional supplementation with probiotics can prevent pathologic bone loss. Here we examined the impact of supplementation with Lactobacillus rhamnosus GG (LGG) on bone homeostasis in eugonadic young mice. Micro-computed tomography revealed that LGG increased trabecular bone volume in mice, which was due to increased bone formation. Butyrate produced in the gut following LGG ingestion, […]

  • Toxoplasma gondii infection triggers chronic cachexia and sustained commensal dysbiosis in mice


    ABSTRACT Toxoplasma gondii is a protozoan parasite with a predation-mediated transmission cycle between rodents and felines. Intermediate hosts acquire Toxoplasma by eating parasite cysts which invade the small intestine, disseminate systemically and finally establish host life-long chronic infection in brain and muscles. Here we show that Toxoplasma infection can trigger a severe form of sustained […]

  • Events
    We maintain a calendar of events and meetings related to the field of Microbiome Research. Check it often for new events and conferences, or submit something for the calendar here.

  • Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice


    Significance Studies using experimental models have indicated that multiple sclerosis (MS)-like disease can be triggered in the gut following interactions of brain autoimmune T lymphocytes with local microbiota.

  • BOOK REVIEW: GNOTOBIOTICS


    Gnotobiotics, edited by Trenton Schoeb and Kathryn Eaton, is invaluable to those developing or managing gnotobiotic facilities.

  • Stress could be just as unhealthy as junk food


    Brigham Young University: We all know that a poor diet is unhealthy, but a new BYU study finds that stress may just as harmful to our bodies as a really bad diet.

  • Infection via mosquito bite alters Zika virus replication kinetics in rhesus macaques


    Abstract For more than three decades it has been recognized that small amounts of vector saliva can significantly alter the infectivity of vector-borne pathogens and subsequent in vivo dynamics.

  • Of Mice, Dirty Mice, and Men: Using Mice To Understand Human Immunology


    Abstract Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans.

  • Microbial Genetic Composition Tunes Host Longevity


    Highlights •Systematic analysis of longevity-promoting microbial genetic variations •Colanic acid as a pro-longevity natural compound effective in different species

  • Learning more about the gut microbiota


    The GMFH editing team recommends these book selections on the topic.

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