The Translational Microbiome Research Forum is an online resource for scientists engaged in translational microbiome research to access current, topical information and to provide a platform to exchange knowledge and ideas. We encourage you to participate by actively using the commenting system, by submitting links, resources, and your original research, and by joining our email list to receive updates when new content is posted.

  • Small molecule inhibitor prevents or impedes tooth cavities in a preclinical model

    University of Alabama at Birmingham researchers have created a small molecule that prevents or impedes tooth cavities in a preclinical model. The inhibitor blocks the function of a key virulence enzyme in an oral bacterium, a molecular sabotage that is akin to throwing a monkey wrench into machinery to jam the gears. In the presence […]

  • New insights regarding how targeting the gut microbiome can improve longevity in the worm Caenorhabditis elegans

    Previous research has shown the aging process and frailty may be associated with a perturbed gut microbiome in elderly people.

  • Core bacteria in the gut of horses showed some stability over time in study

    Researchers have shown that a core bacterial community in the hindgut of horses shows some degree of stability over time when the animals are on a uniform diet.

  • Reality vs. hype: A macro look at the microbiome market
    3d render Bacteria blue closeup (depth  of field)

    What hasn’t the microbiome been linked to in mice? For years, the potential therapeutic value of our so-called “second genome” has been celebrated in successive press releases from researchers around the world.

  • 2017 Massry Prize Honors Microbiome Research Pioneers
    Rob Knight at UC San Diego in La Jolla, Calif. on Tuesday June 16, 2015. Photograph by Tracy Boulian and David Ahntholz

© Copyright 2015 Tracy Boulian and David Ahntholz

    Microbiome researchers Rob Knight, PhD, University of California San Diego, Jeffrey Gordon, MD, Washington University School of Medicine in St. Louis, and Norman Pace, PhD, University of Colorado Boulder, will share this year’s Massry Prize, splitting the $200,000 honorarium.

  • Blueberries and black tea can help your gut bacteria fight the flu

    A common gut bacterium may break down compounds found in blueberries, black tea and other foods to boost interferon and help your immune system fight the influenza virus

  • How a tick gut gene serves as a gateway for Lyme disease

    The bacterium that causes Lyme disease, Borrelia burgdorferi, may have some help from a gene found in the guts of infected ticks, according to a new study led by Yale researchers and published in Nature Communications.

  • How Bacteria in Your Gut Play a Role in Lupus

    New research explores how the tiny organisms in your gut might be influencing your immune system and lupus disease activity


    TORONTO, Aug. 1, 2017 /CNW/ – Crohn’s and Colitis Canada is pleased to announce its Grants-in-Aid and Innovations in Inflammatory Bowel Disease (IBD) Grant recipients.

  • Complex interactions of circadian rhythms, eating behaviors, and the gastrointestinal microbiota and their potential impact on health

    Abstract Human health is intricately intertwined with the composition and function of the trillions of microorganisms that make up the gastrointestinal (GI) microbiome.

  • Structure-Based Discovery of Small Molecule Inhibitors of Cariogenic Virulence
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    Abstract Streptococcus mutans employs a key virulence factor, three glucosyltransferase (GtfBCD) enzymes to establish cariogenic biofilms.

  • The impact of age and gut microbiota on Th17 and Tfh cells in K/BxN autoimmune arthritis

    Abstract Background Age is an important risk factor for rheumatoid arthritis (RA), which often develops in middle age. However, how age-associated changes in immunity impact RA is poorly understood.

  • Human Gut-Derived Commensal Bacteria Suppress CNS Inflammatory and Demyelinating Disease
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    Highlights • A human gut bacterium has potential as a therapy for multiple sclerosis (MS) • P. histicola can suppress disease in a preclinical animal model of MS • P. histicola suppresses disease by inducing CD4+ FoxP3+ regulatory T cells

  • Heme-oxygenase-1 Production by Intestinal CX3CR1+ Macrophages Helps to Resolve Inflammation and Prevents Carcinogenesis

    Abstract CX3CR1+ macrophages in the intestinal lamina propria contribute to gut homeostasis through the immunomodulatory interleukin IL10, but there is little knowledge on how these cells or the CX3CR1 receptor may affect colorectal carcinogenesis.

  • Changes in the Total Fecal Bacterial Population in Individual Horses Maintained on a Restricted Diet Over 6 Weeks

    Twelve mature (aged 5–16 years) horses and ponies of mixed breed and type were fed restricted (1.25% BM Dry matter) quantities of one of two fiber based diets formulated to be iso-caloric.

  • The Effects of Captivity on the Mammalian Gut Microbiome

    Abstract Recent studies increasingly note the effect of captivity or the built environment on the microbiome of humans and other animals.

  • Fenugreek galactomannan and citrus pectin improve several parameters associated with glucose metabolism, and modulate gut microbiota in mice

    Highlights •For the first time galactomannan, derived from fenugreek and pectin, derived from citrus where shown to modulate gut microbiota and effect metabolic parameters and gene expression related to glucose metabolism.

  • The Gut Microbiome and Mental Health: Implications for Anxiety- and Trauma-Related Disorders.

    Abstract Biological psychiatry research has long focused on the brain in elucidating the neurobiological mechanisms of anxiety- and trauma-related disorders.

  • Space invaders: the challenges of studying microbes in space

    Srimathy Sriskantharajah (BSc in Microbiology (UCL) and a PhD in environmental microbiology/ atmospheric chemistry (Royal Holloway University of London): Conducting research on Earth is challenging enough for most of us, but what if your research specialty is studying organisms in space?


    From James Vitale, Marketing Program Director: Part I: Participants and Presentations This is the first of a three-part recap of Navigating the Challenges of Studying the Microbiome in Mouse Models: Design, Execution and Utility, a sponsored workshop at the 2017 Translational Microbiome Conference.

  • Events
    We maintain a calendar of events and meetings related to the field of Microbiome Research. Check it often for new events and conferences, or submit something for the calendar here.

  • Microbial Genetic Composition Tunes Host Longevity
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    Highlights •Systematic analysis of longevity-promoting microbial genetic variations •Colanic acid as a pro-longevity natural compound effective in different species •Bacterial metabolites regulate host mitochondrial dynamics and UPRmit Summary Homeostasis of the gut microbiota critically influences host health and aging. Developing genetically engineered probiotics holds great promise as a new therapeutic paradigm to promote healthy aging.

  • Learning more about the gut microbiota
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    The GMFH editing team recommends these book selections on the topic.

  • Effects of iron supplementation on growth, gut microbiota, metabolomics and cognitive development of rat pups

    Abstract Background Iron deficiency is common during infancy and therefore iron supplementation is recommended.

  • VIDEO: BioEssays: Brain carnitine deficiency causes nonsyndromic autism with an extreme male bias

    Arthur Beaudet discusses the importance of diet, genes, epigenetics, drugs, microbiome, and minor illnesses (especially gastrointestinal) in the hypothesis.

  • From complex gut communities to minimal microbiomes via cultivation

    Highlights •Microbiome research will benefit from the complementary use of culture and molecular approaches.

  • Detection of Helicobacter pylori in the Gastric Mucosa by Fluorescence In Vivo Hybridization

    Abstract In this chapter, we describe a fluorescence in vivo hybridization (FIVH) protocol, using nucleic acid probes, for the detection of the bacterium Helicobacter pylori in the gastric mucosa of an infected C57BL/6 mouse model.

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