The microbiome consists of about 100 trillion microbes (microbiota) and their genomes. These are made of bacteriophage, fungi, bacteria, protozoa (single-cell eukaryotes), and viruses in the human body. They play an important role in health maintenance systems of the immune system, as well as in drugs and foreign substances (xenobiotics) metabolism. Researchers have discovered that […]
UT Southwestern researchers have found a key driver of the crosstalk that helps synchronize the absorption of nutrients in the gut with the rhythms of the Earth’s day-night light cycle. Their findings could have far-ranging implications for obesity in affluent countries and malnutrition in impoverished countries. In the study, Dr. Lora Hooper and her research […]
Mice (and maybe people) may metabolize food according to daily, circadian rhythms set by gut bacteria. Microbes in the small intestine of mice rhythmically dictate when fat is taken up by cells that line the organ, researchers report. The study, described in the Sept. 27 Science, details how gut microbes influence a host’s metabolism. If […]
A recent study published in Nature Medicine reports on the correlation between rigorous exercise and the increase in abundance of a specific bacterial genus in the human gut microbiome. The collaborative group, which includes CRISPR-researcher George Church from Harvard Medical School, established a connection between the abundance of Veillonella atypica and an increased ability to […]
Taconic Biosciences’ Marina Hanson DVM, PhD presents this exclusive webinar where she describes how TruBIOME™ enables the generation and maintenance of mice with defined custom microbiome profiles, including insight into the Wild Mouse gut microbiota. Watch today to learn: About the Wild Mouse gut microbiome and how it varies from the microbiota of standard laboratory […]
The tools of chemical biology, genomics and data mining can yield insights into the metabolites of the microbiome. Studies of the microorganisms that live on and inside animals’ bodies have long relied on DNA sequencing, which can reveal which species abound and how these microbial communities respond to their environment. Now, the analytical methods of […]
The Human Microbiome Project’s former Program Coordinator, Lita Proctor, set out priorities for the next ten years of human microbiome research in a wide-ranging article for Nature. She also provides reflections on the completed Human Microbiome Project that helped jump-start microbiome research in the US and beyond. In the past ten years microbiome research has […]
Resulting Studies Will Provide Critical Reference Data to Drive Advancements in Human Health Rensselaer, NY — September 3, 2019 – Taconic Biosciences, a global leader in providing genetically engineered animal model solutions, announces its participation in the second Rodent Research Reference (RRR) mission to the International Space Station. Taconic has a history with NASA dating […]
What is M-SCI? The Microbiomics Standards & Controls Initiative Receive free standards and controls. Improve accuracy and data reproducibility. Help the field of Microbiomics incorporate controls and standards in every experiment. Why Give Away Free Standards & Controls? Availability is Key to Standardization Leaders in the field of microbiomics have recognized that the lack of […]
ABSTRACT Vasoactive intestinal peptide (VIP) is crucial for gastrointestinal tract (GIT) health. VIP sustains GIT homeostasis through maintenance of the intestinal epithelial barrier and acts as a potent anti-inflammatory mediator that contributes to gut bacterial tolerance. Based on these biological functions by VIP, we hypothesized that its deficiency would alter gut microbial ecology. To this […]
Vasoactive intestinal peptide (VIP) is crucial for gastrointestinal tract (GIT) health. VIP sustains GIT homeostasis through maintenance of the intestinal epithelial barrier and acts as a potent anti-inflammatory mediator that contributes to gut bacterial tolerance. Based on these biological functions by VIP, we hypothesized that its deficiency would alter gut microbial ecology. To this end, […]
ABSTRACT BACKGROUND Watermelon intake has demonstrated effects on blood pressure regulation along with other health benefits. OBJECTIVE We hypothesized that intake of whole watermelon and products made from watermelon rind (WR) and watermelon skin (WS) would remediate metabolic complications in C57BL/6 J male mice fed a diet modeling a Western-style diet. METHODS Ten-week-old male C57BL/6 […]
ABSTRACT Recently, increasing evidence has suggested the association between gut dysbiosis and Alzheimer’s disease (AD) progression, yet the role of gut microbiota in AD pathogenesis remains obscure. Herein, we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression. Using AD mouse models, we discovered that, during AD progression, the alteration […]
ABSTRACT How the microbiota modulate immune functions remains poorly understood. Mucosal-associated invariant T (MAIT) cells are implicated in mucosal homeostasis and absent in germ-free mice. Here, we show that commensal bacteria govern murine MAIT intrathymic development, as MAIT cells did not recirculate to the thymus. MAIT development required RibD expression in bacteria, indicating that production […]
ABSTRACT Multicellular organisms have co-evolved with complex consortia of viruses, bacteria, fungi and parasites, collectively referred to as the microbiota. In mammals, changes in the composition of the microbiota can influence many physiologic processes (including development, metabolism and immune cell function) and are associated with susceptibility to multiple diseases. Alterations in the microbiota can also […]
ABSTRACT Sulfate-reducing bacteria (SRB) are often isolated from animals and people with ulcerative colitis and can be involved in the IBD development in the gut–intestine axis. The background of the research consisted of obtaining mixed cultures of SRB communities from healthy mice and mice with colitis, finding variation in the distribution of their morphology, to […]
ABSTRACT There is growing awareness within the scientific community of the strong connection between the inflammation in the intestine and the pathogenesis of Parkinson’s disease (PD). In previous studies we developed a PD animal model exposing pup rats to permethrin (PERM) pesticide. Here, we intended to explore whether in our animal model there were changes […]
ABSTRACT H1 parvovirus (H1PV) infection in rats is of concern to the research community as infection may compromise rodent-based experiments. The aim of this study was to evaluate the influence of H1PV infection on rat gut microbiota. Inbred Wistar rats were infected with H1PV by routine gavage and clinical signs were recorded. Gross anatomical and […]
Significance Studies using experimental models have indicated that multiple sclerosis (MS)-like disease can be triggered in the gut following interactions of brain autoimmune T lymphocytes with local microbiota.
Gnotobiotics, edited by Trenton Schoeb and Kathryn Eaton, is invaluable to those developing or managing gnotobiotic facilities.
Brigham Young University: We all know that a poor diet is unhealthy, but a new BYU study finds that stress may just as harmful to our bodies as a really bad diet.
Abstract For more than three decades it has been recognized that small amounts of vector saliva can significantly alter the infectivity of vector-borne pathogens and subsequent in vivo dynamics.
Abstract Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans.
Highlights •Systematic analysis of longevity-promoting microbial genetic variations •Colanic acid as a pro-longevity natural compound effective in different species