The gut microbiome is crucial to health, encompassing bacterial communities that possess a hundred times more genes than the human genome.
Celiac disease (CeD) is a complex immune mediated disorder that is triggered by abnormal immune responses to the dietary protein gluten, which is found in grains like wheat, barley, and rye.
As scientists continue their exploration of the thousands of organisms that live inside our body, a new study is showing just how much one “good” bacteria can be exploited to its host’s advantage.
Gut microbes are one of the culprits behind age-associated inflammation and premature death in mice, a new study has found. Inflammation increases with age and is a strong risk factor for death in the elderly, but the underlying cause has not been clear.
Inflammation increases with age and is a strong risk factor for death in the elderly, but the underlying cause has not been clear.
New research with mice by McMaster University in Canada suggests gut microbes can lead to age-related inflammation and premature death.
A study on mice suggests that taking the common antibiotic penicillin when pregnant could alter the brain chemistry of your offspring.
The global prevalence of autoimmune conditions such as type-1 diabetes, rheumatoid arthritis, and celiac disease has increased rapidly over the most recent decades.
Abstract The high susceptibility of neonates to infections has been assumed to be due to immaturity of the immune system, but the mechanism remains unclear.
Highlights •We introduce tools for modulating microbiome gene expression inside the gut •Engineered promoters couple gene expression in Bacteroides to a synthetic inducer
Abstract Accumulating evidence suggests that the gut microbiota dysbiosis and their host metabolic phenotype alteration is an important factor in human disease development.
Viruses compound dietary pathology Reoviruses commonly infect humans and mice asymptomatically. Bouziat et al. found that immune responses to two gut-infecting reoviruses take different paths in mice (see the Perspective by Verdu and Caminero).
Abstract Background Within seven days following peroral high dose infection with Toxoplasma gondii susceptible conventionally colonized mice develop acute ileitis due to an underlying T helper cell (Th) -1 type immunopathology.
Abstract PURPOSE OF REVIEW Inflammatory bowel diseases (IBDs) develop as a result of a combination of genetic predisposition, dysbiosis of the gut microbiota, and environmental influences.
Highlights •Age-associated inflammation drives macrophage dysfunction and tissue damage •Mice under germ-free conditions are protected from age-associated inflammation •Co-housing germ-free mice with old, but not young, mice increases age-related inflammation •Age-related microbiota changes can be reversed by reducing TNF levels
Abstract Purpose The protective function of the intestinal mucosa largely depends on carbohydrate moieties that as a part of glycoproteins and glycolipids form the epithelial glycocalyx or are secreted as mucins.
Abstract Background It is well known that the microbiota of high-fat (HF) diet-induced obese mice differs from that of lean mice, but to what extent, this difference reflects the obese state or the diet is unclear.
By Julia Evangelou Strait: Jeffrey I. Gordon, MD, is expanding our understanding of human health into nonhuman realms, studying the bacteria that take up residence in the gut and help define who we become. Indeed, this research suggests you are what you — and your microbes — eat.
At first glance, it may appear that scientists and artists look at the world in different ways, but look again: Careful observation is at the heart of both callings. “Microbiomes: To See the Unseen,” the latest collaboration between the arts and sciences at The Arts Center in Corvallis, takes that observation to a microscopic level:
Of Microbes and Men You Should Appreciate Germs By Bill Gates Find Out More: gatesnotes
Identifying intestinal microbiota is arguably an important task that is performed to determine the pathogenesis of inflammatory bowel diseases (IBD); thus, it is crucial to collect and analyze intestinally-associated microbiota.
In this brief video, Dr. B. Brett Finlay describes the fascinating world of microbes, and tells the story of his discovery of the E-Coli 0157 vaccine:
AsapScience, stylized as AsapSCIENCE, is a YouTube channel created by Canadian youtubers Mitchell Moffit and Gregory Brown. The channel produces weekly videos that touch on many different topics of science. Check Out Here: AsapSCIENCE
The investigation of wildlife gastrointestinal microbiomes by next-generation sequencing approaches is a growing field in microbial ecology and conservation.
Summary The influence of gut microbiota on human health has been well documented, particularly in the case of metabolic disorders, such as type 1 and type 2 diabetes.