The Translational Microbiome Research Forum is an online resource for scientists engaged in translational microbiome research to access current, topical information and to provide a platform to exchange knowledge and ideas. We encourage you to participate by actively using the commenting system, by submitting events, and by joining our email list to receive updates when new content is posted.

  • QIAGEN announces winners of 2018 Microbiome Awards competition

    Two extraordinary young scientists honored with prizes and more than $100,000 in support for research into the impacts of microbial communities on human health Hilden, Germany, and Germantown, Maryland, October 17, 2018 – QIAGEN today announced the winners of its fifth annual 2018 Microbiome Awards, a competition for outstanding researchers working on diverse aspects of […]

  • Housing Systems for Rodents Used in Microbiome Research


    Gnotobiotic technology in laboratory animal science is the processes and systems employed for maintaining gnotobiotic and germfree (germfree) research animals. Through sterilization of feed and other husbandry supplies, and by housing in systems that completely protect the animals from the surrounding environment and human caretakers, the intent is to create and maintain animal models with […]

  • uBiome Launches Innovation Challenge to Advance Microbiome Clinical Outcomes Research

    Submissions to the uBiome Clinical Outcomes in Microbial Genomics Innovation Challenge are now open, welcoming applications from healthcare providers, students, trainees, and researchers worldwide. Winning proposals will receive grants which include access to uBiome’s clinical testing kits, as well as microbiome sequencing and bioinformatics services. “uBiome is thrilled to further expand our collaborations in the […]

  • Webinar Q&A — Cyclical Bias


    In a recent webinar, Dr. Alexander Rodriguez-Palacios of Case Western Reserve University School of Medicine discussed a confounding influence on many common microbiome study endpoints uncovered in studies using the NesTiso system. The NesTiso system has been described in a previous publication1 and examined in an on-demand webinar. There were several outstanding questions submitted by […]

  • Bringing order to the ‘wild frontier’ of microbiome medicine


    I never thought I’d someday write the sentence, “I really enjoyed that FDA meeting.” But here I am doing just that. The topic of the meeting — regulatory implications of an emerging class of medicines to promote health by modulating the teeming microbial ecosystems that live inside each of us — may not sound like […]

  • Pancreatic Cancer Microbiome Suppresses Immune Responses


    Alterations in the microbiome have an acknowledged role in cancer pathology1,2. Earlier this year, however, researchers at New York University published a manuscript3 connecting the pancreatic microbiome to cancer progression. In this report, Pushalkar et al. demonstrate that the endogenous microbiome of the pancreas can drive immunosuppressive conditions in humans and mice, which creates a […]

  • Animal Husbandry in Microbiome Research: 2018 RIGOR & REPRODUCIBILITY SURVEY


    The directors of the NIH funded Digestive Disease Research Core Centers (DDRCC) are conducting a survey to examine the perceptions of how animal husbandry and experimental practices influence microbiome data variability. DDRCC In March 2018, representatives from six of the eighteen DDRCC gathered for their annual Midwest Alliance meeting to discuss the latest findings in […]

  • Webinar Q&A — Nested Isolation


    In a recent webinar, Dr. Alex Rodriguez-Palacios of Case Western Reserve University School of Medicine discussed the use of a new, low-cost caging system for conducting microbiome research in rodents. The speaker shared their experience with the NesTiso system and discussed: How NesTiso makes gnotobiotic research simple and practical How to inexpensively verify the germ-free […]

  • Book Review: Animal Models for Microbiome Research


    This book is the outcome of Workshop on Animal Models for Microbiome Research: Advancing Basic Science and Translational Research, hosted by the Institute for Laboratory Animal Research (ILAR). Microbiome and germ-free researchers James Fox, Joseph Newsome, Wendy Garrett, Jeffrey Gordon and Vincent Young organized the workshop, with the following goals: Improve the depth and breadth […]

  • Nitrated meat products are associated with mania in humans and altered behavior and brain gene expression in rats


    ABSTRACT Mania is a serious neuropsychiatric condition associated with significant morbidity and mortality. Previous studies have suggested that environmental exposures can contribute to mania pathogenesis. We measured dietary exposures in a cohort of individuals with mania and other psychiatric disorders as well as in control individuals without a psychiatric disorder. We found that a history […]

  • Microbial Changes and Host Response in F344 Rat Colon Depending on Sex and Age Following a High-Fat Diet


    Gut microbiota, an important component that affects host health, change rapidly and directly in response to altered diet composition. Recently, the role of diet–microbiome interaction on the development of colon cancer has been the focus of interest. Colon cancer occurs more frequently in an aged population, and in males. However, the effect of dietary changes […]

  • Replication Study: Intestinal inflammation targets cancer-inducing activity of the microbiota


    ABSTRACT As part of the Reproducibility Project: Cancer Biology we published a Registered Report (Eaton et al., 2015) that described how we intended to replicate selected experiments from the paper “Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota” (Arthur et al., 2012). Here we report the results. We observed no impact on bacterial growth or […]

  • Chronic nonbacterial prostate inflammation in a rat model is associated with changes of gut microbiota that can be modified with a galactoglucomannan‐rich hemicellulose extract in diet

    ABSTRACT Objectives To investigate dietary effects on the gut microbiota composition in a rat model of chronic non‐bacterial prostate inflammation. Materials and Methods Chronic nonbacterial prostate inflammation in the Wistar rat strain was induced with subcutaneous testosterone and 17β‐oestradiol hormone pellets for 18 weeks. Rats with placebo pellets served as healthy controls. Rats with chronic […]

  • Nod2 Deficiency in mice is Associated with Microbiota Variation Favouring the Expansion of mucosal CD4+ LAP+ Regulatory Cells


    ABSTRACT Nucleotide-binding Oligomerization Domain-2 (NOD2) mutations are associated with an increased risk to develop Crohn’s Disease. In previous studies, we have shown that Nod2−/− mice manifest increased proportion of Lamina Propria (LP) CD4+ LAP+ Foxp3− regulatory cells, when compared with Nod2+/+ mice, while CD4+ Foxp3 + regulatory cells were not affected. Here, we investigated the Nod2 gut […]

  • The mammalian mycobiome: A complex system in a dynamic relationship with the host


    ABSTRACT Mammalian barrier surfaces are densely populated by symbiont fungi in much the same way the former are colonized by symbiont bacteria. The fungal microbiota, otherwise known as the mycobiota, is increasingly recognized as a critical player in the maintenance of health and homeostasis of the host. Here we discuss the impact of the mycobiota […]

  • Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells


    SUMMARY From an organismal perspective, cancer cell populations can be considered analogous to parasites that compete with the host for essential systemic resources such as glucose. Here, we employed leukemia models and human leukemia samples to document a form of adaptive homeostasis, where malignant cells alter systemic physiology through impairment of both host insulin sensitivity […]

  • Intestinal anti-inflammatory effect of the probiotic Saccharomyces boulardii in DSS-induced colitis in mice: Impact on microRNAs expression and gut microbiota composition


    ABSTRACT The beneficial effects exerted by probiotics in inflammatory bowel disease (IBD) are well known, although their exact mechanisms have not been fully elucidated, and only few studies have focused on their impact on selected miRNAs and the gut microbiota composition. Therefore, our aim was to correlate the intestinal anti-inflammatory activity of the probiotic Saccharomyces […]

  • Sex Differences in Pulmonary Responses to Ozone in Mice: Role of the Microbiome

    ABSTRACT We have previously reported that the mouse gut microbiome contributes to pulmonary responses to ozone, a common asthma trigger, and that short chain fatty acids, end products of bacterial fermentation, likely contribute to this role of the microbiome. A growing body of evidence indicates sex-related differences in gut microbiota and that these differences can […]

  • Events
    We maintain a calendar of events and meetings related to the field of Microbiome Research. Check it often for new events and conferences, or submit something for the calendar here.

  • Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice


    Significance Studies using experimental models have indicated that multiple sclerosis (MS)-like disease can be triggered in the gut following interactions of brain autoimmune T lymphocytes with local microbiota.

  • BOOK REVIEW: GNOTOBIOTICS


    Gnotobiotics, edited by Trenton Schoeb and Kathryn Eaton, is invaluable to those developing or managing gnotobiotic facilities.

  • Stress could be just as unhealthy as junk food


    Brigham Young University: We all know that a poor diet is unhealthy, but a new BYU study finds that stress may just as harmful to our bodies as a really bad diet.

  • Infection via mosquito bite alters Zika virus replication kinetics in rhesus macaques


    Abstract For more than three decades it has been recognized that small amounts of vector saliva can significantly alter the infectivity of vector-borne pathogens and subsequent in vivo dynamics.

  • Of Mice, Dirty Mice, and Men: Using Mice To Understand Human Immunology


    Abstract Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans.

  • Microbial Genetic Composition Tunes Host Longevity


    Highlights •Systematic analysis of longevity-promoting microbial genetic variations •Colanic acid as a pro-longevity natural compound effective in different species

  • Learning more about the gut microbiota


    The GMFH editing team recommends these book selections on the topic.

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