A recent study published in Nature Medicine reports on the correlation between rigorous exercise and the increase in abundance of a specific bacterial genus in the human gut microbiome. The collaborative group, which includes CRISPR-researcher George Church from Harvard Medical School, established a connection between the abundance of Veillonella atypica and an increased ability to […]
Taconic Biosciences’ Marina Hanson DVM, PhD presents this exclusive webinar where she describes how TruBIOME™ enables the generation and maintenance of mice with defined custom microbiome profiles, including insight into the Wild Mouse gut microbiota. Watch today to learn: About the Wild Mouse gut microbiome and how it varies from the microbiota of standard laboratory […]
The tools of chemical biology, genomics and data mining can yield insights into the metabolites of the microbiome. Studies of the microorganisms that live on and inside animals’ bodies have long relied on DNA sequencing, which can reveal which species abound and how these microbial communities respond to their environment. Now, the analytical methods of […]
The Human Microbiome Project’s former Program Coordinator, Lita Proctor, set out priorities for the next ten years of human microbiome research in a wide-ranging article for Nature. She also provides reflections on the completed Human Microbiome Project that helped jump-start microbiome research in the US and beyond. In the past ten years microbiome research has […]
Resulting Studies Will Provide Critical Reference Data to Drive Advancements in Human Health Rensselaer, NY — September 3, 2019 – Taconic Biosciences, a global leader in providing genetically engineered animal model solutions, announces its participation in the second Rodent Research Reference (RRR) mission to the International Space Station. Taconic has a history with NASA dating […]
What is M-SCI? The Microbiomics Standards & Controls Initiative Receive free standards and controls. Improve accuracy and data reproducibility. Help the field of Microbiomics incorporate controls and standards in every experiment. Why Give Away Free Standards & Controls? Availability is Key to Standardization Leaders in the field of microbiomics have recognized that the lack of […]
Microbiome, Environmental Microbiome and Animal Microbiome are coming together to launch a special series inviting authors to submit their research pertaining to antimicrobial resistance (AMR) and the microbiome. The emergence and spread of AMR can only be described as a catastrophic problem for human and animal health. It is projected that there would be more […]
The microbiome includes not just bacteria, but also fungi, viruses and parasites. While most of the attention has been on bacterial components of the microbiome, new research links a commensal yeast found on human skin to disease severity in inflammatory bowel disease (IBD). Linking Common Fungi with IBD Severity In a new paper published in […]
You are what you eat — right down to the microbiome living in your gut. Diet can affect which microbes are in the intestinal tract, and research has shown that harmful gut microbiome changes can lead to illnesses such as heart disease, obesity and cancer. Today, scientists will report the development of molecules that can […]
ABSTRACT Obesity and its comorbidities are currently considered an epidemic, and the involved pathophysiology is well studied. Hypercaloric diets are tightly related to the obesity etiology and also cause alterations in gut microbiota functionality. Diet and antibiotics are known to play crucial roles in changes in the microbiota ecosystem and the disruption of its balance; […]
ABSTRACT Background: Pancreatic ductal adenocarcinoma’s (PDAC) growing incidence has been linked to the rise in obesity and type 2 diabetes mellitus. In previous work we have shown that metformin can prevent the increased incidence of PDAC in a KrasG12D mouse model subjected to a diet high in fat and calories (HFCD). One potential way that […]
SUMMARY Graft-versus-host disease (GVHD) in the gastrointestinal (GI) tract is the principal determinant of lethality following allogeneic bone marrow transplantation (BMT). Here, we examined the mechanisms that initiate GVHD, including the relevant antigen-presenting cells. MHC class II was expressed on intestinal epithelial cells (IECs) within the ileum at steady state but was absent from the […]
ABSTRACT Gut microbiota and their metabolites (short-chain fatty acids, SCFAs) are associated with the pathogenesis of rheumatoid arthritis (RA). Total Clematis triterpenoid saponins (CTSs) prepared from Clematis mandshurica Rupr. possess therapeutic benefits for arthritic diseases. However, the poor pharmacokinetic properties of CTSs have obstructed the translation of these natural agents to drugs. Here, we examined […]
ABSTRACT As technologies used to study the gut microbiota have improved, the relationship between the gut microbiota and health has become increasingly obvious. Herbal medicines have been used for thousands of years, and are known to be “simple, convenient, cheap, and effective”. However, due to many factors, such as their complex composition, unclear active compounds, […]
ABSTRACT Evidence in support of a gut-muscle axis has been reported in rodents, but studies in older adult humans are limited. Accordingly, the primary goals of the present study were to compare gut microbiome composition in older adults that differed in terms of the percentage of whole body lean mass and physical functioning (high-functioning, HF, […]
ABSTRACT Evidence has accumulated that the gut microbiota is an important environmental factor contributing to obesity by altering host energy harvest and storage. We performed a high-throughput 16S rDNA sequencing association study and serum metabolomics profiling in rat with high-sugar diet. Our studies revealed that high sugar diet reduced the diversity of cecal microorganisms, while […]
SUMMARY Emerging evidence indicates a central role for the microbiome in immunity. However, causal evidence in humans is sparse. Here, we administered broad-spectrum antibiotics to healthy adults prior and subsequent to seasonal influenza vaccination. Despite a 10,000-fold reduction in gut bacterial load and long-lasting diminution in bacterial diversity, antibody responses were not significantly affected. However, […]
A microbial bond is shared between mother and child that renders the age-old dichotomy of “nature versus nurture” obsolete. Molded by both host biology and the physical relationship between mother and child, this microbial connection is formed at the earliest moments of life when the newborn’s skin and mucosal surfaces are seeded with microorganisms that […]
Significance Studies using experimental models have indicated that multiple sclerosis (MS)-like disease can be triggered in the gut following interactions of brain autoimmune T lymphocytes with local microbiota.
Gnotobiotics, edited by Trenton Schoeb and Kathryn Eaton, is invaluable to those developing or managing gnotobiotic facilities.
Brigham Young University: We all know that a poor diet is unhealthy, but a new BYU study finds that stress may just as harmful to our bodies as a really bad diet.
Abstract For more than three decades it has been recognized that small amounts of vector saliva can significantly alter the infectivity of vector-borne pathogens and subsequent in vivo dynamics.
Abstract Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans.
Highlights •Systematic analysis of longevity-promoting microbial genetic variations •Colanic acid as a pro-longevity natural compound effective in different species