The Translational Microbiome Research Forum is an online resource for scientists engaged in translational microbiome research to access current, topical information and to provide a platform to exchange knowledge and ideas. We encourage you to participate by actively using the commenting system, by submitting links, resources, and your original research, and by joining our email list to receive updates when new content is posted.

  • Gut Microbiome Assemblage Impacts Response to Cancer Immunotherapy

    University of Chicago Medicine researchers report that specific microbiome assemblages can boost the response rate to immunotherapy for patients being treated for advanced melanoma. Their study (”The Commensal Microbiome Is Associated with Anti–PD-1 Efficacy in Metastatic Melanoma Patients”) is published in Science. “Anti–PD-1–based immunotherapy has had a major impact on cancer treatment but has only […]

  • Gordon receives Sanofi-Institut Pasteur Award

    Scientist honored for role in founding, leading field of gut microbiome research Jeffrey I. Gordon, MD, a world-renowned scientist at Washington University School of Medicine in St. Louis, has received the Sanofi-Institut Pasteur International Award for his role in founding and leading the field of gut microbiome research. Together with talented students and colleagues, Gordon’s […]

  • A New Antibiotic Weakness—Drugs Themselves Help Bacteria Survive

    Antibiotics save lives, but they are not fail-safe. Even when microbes haven’t acquired drug-evading genetic mutations—a hallmark of antibiotic resistance—the medications don’t always clear infections. A new study identifies a surprising reason why: At infection sites, antibiotics change the natural mixture of chemicals made by the body in ways that protect infecting bacteria. They also […]

  • TH17-INDUCING GUT BACTERIA CAN PROMOTE AUTISM-LIKE BEHAVIOR IN MOUSE PUPS


    On September 13, 2017 researchers from the Massachusetts Institute of Technology and the University of Massachusetts Medical School simultaneously published papers in Nature on the same intriguing topic: a link between autism and infection during pregnancy.

  • Gut bacteria could determine whether you develop PTSD


    Molecular Biologists found that you’re more likely to develop PTSD if you lack in certain immune supporting bacteria

  • Gut microbes could help trigger multiple sclerosis


    The trillions of bacteria that live in our intestines, known collectively as the gut microbiome, have been linked to maladies from eye disease to rheumatoid arthritis. Now, two new studies have added another disease: multiple sclerosis (MS)

  • The Next Big Performance Enhancing Drug: Bacteria From Elite Athletes’ Guts?


    When Jonathan Scheiman describes his lab as “a lot of crazy shit,” he’s not kidding. For the last three years, the 35-year-old molecular biologist has been working at Harvard University studying the, um, stool of pro marathoners, ultra- runners, and Olympic rowers.

  • Two new studies support the link between the gut microbiome and multiple sclerosis


    Previous research has found that multiple sclerosis (MS) patients may have a specific microbial signature in their gut microbiota that could impact disease pathogenesis.

  • Enterome’s EB8018, a First-in-class Drug Candidate Targeting Crohn’s Disease, Successfully Completes Phase I Study in Healthy Volunteers


    ENTEROME SA, a pioneer of innovative therapies for microbiome-related diseases, is pleased to announce the successful completion of the first Phase 1 clinical study with its lead candidate EB8018, a small molecule designed to block FimH, as a potential new orally-administered treatment for Crohn’s disease.

  • Proton Pump Inhibitors Increase the Susceptibility of Mice to Oral Infection with Enteropathogenic Bacteria

    ABSTRACT Proton pump inhibitors (PPIs) are among the most frequently prescribed medications. Side effects including an increased risk of intestinal infections have been reported. It is assumed that PPIs can increase susceptibility to enteropathogens; however, the underlying mechanisms are unknown. Here in this study, we explored whether Lansoprazole (Laz), one of the PPIs, increases the […]

  • Fecal Microbiota Transplantation, Commensal Escherichia coli and Lactobacillus johnsonii Strains Differentially Restore Intestinal and Systemic Adaptive Immune Cell Populations Following Broad-spectrum Antibiotic Treatment

    ABSTRACT The essential role of the intestinal microbiota in the well-functioning of host immunity necessitates the investigation of species-specific impacts on this interplay. Aim of this study was to examine the ability of defined Gram-positive and Gram-negative intestinal commensal bacterial species, namely Escherichia coli and Lactobacillus johnsonii, respectively, to restore immune functions in mice that […]

  • Maternal metabolic, immune, and microbial systems in late pregnancy vary with malnutrition in mice.

    ABSTRACT Malnutrition is a global threat to pregnancy health and impacts offspring development. Establishing an optimal pregnancy environment requires the coordination of maternal metabolic and immune pathways, which converge at the gut. Diet, metabolic and immune dysfunctions have been associated with gut dysbiosis in the non-pregnant individual. In pregnancy, these states are associated with poor […]

  • Physiological Translocation of Lactic Acid Bacteria during Pregnancy Contributes to the Composition of the Milk Microbiota in Mice

    ABSTRACT The human milk microbiota is a complex and diverse ecosystem that seems to play a relevant role in the mother-to-infant transmission of microorganisms during early life. Bacteria present in human milk may arise from different sources, and recent studies suggest that at least some of them may be originally present in the maternal digestive […]

  • Changes in mouse gut bacterial community in response to different types of drinking water

    ABSTRACT Gut microbiota exerts a fundamental role on host physiology, and how extrinsic perturbations influence its composition has been increasingly examined. However, the effect of drinking water on gut microbiota is still poorly understood. In this study, we explored the response of mouse gut bacterial community (fecal and mucosa-adhered) to the ingestion of different types […]

  • Microbiota Reconstitution Does Not Cause Bone Loss in Germ-Free Mice

    ABSTRACT Annually, an estimated 2 million osteoporotic fractures occur in the United States alone. Osteoporosis imparts a great burden on the health care system. The identification of novel regulators of bone health is critical for developing more effective therapeutics. A previous study on the colonization of germ-free (GF) mice with a microbial community has demonstrated […]

  • The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients

    ABSTRACT Anti–PD-1–based immunotherapy has had a major impact on cancer treatment but has only benefited a subset of patients. Among the variables that could contribute to interpatient heterogeneity is differential composition of the patients’ microbiome, which has been shown to affect antitumor immunity and immunotherapy efficacy in preclinical mouse models. We analyzed baseline stool samples […]

  • Particle size determines the anti-inflammatory effect of wheat bran in a model of fructose over-consumption: Implication of the gut microbiota

    ABSTRACT We investigated the impact of the particle size of wheat bran on gut dysbiosis and inflammation induced by a fructose overload. Mice received drinking water with or without fructose (30%) and a standard diet supplemented with or without 5% of wheat bran fractions characterized by different average particle sizes (1690 µm versus 150 µm) for 8 weeks. […]

  • Intestinal Ralstonia pickettii augments glucose intolerance in obesity

    ABSTRACT An altered intestinal microbiota composition has been implicated in the pathogenesis of metabolic disease including obesity and type 2 diabetes mellitus (T2DM). Low grade inflammation, potentially initiated by the intestinal microbiota, has been suggested to be a driving force in the development of insulin resistance in obesity. Here, we report that bacterial DNA is […]

  • Q&A: Friends (but sometimes foes) within: the complex evolutionary ecology of symbioses between host and microbes

    ABSTRACT Over the past decade, there has been a pronounced shift in the study of host–microbe associations, with recognition that many of these associations are beneficial, and often critical, for a diverse array of hosts. There may also be pronounced benefits for the microbes, though this is less well empirically understood. Significant progress has been […]

  • The Association for Gnotobiotics, Inc. invites you to join our revitalized organization!!

    The Association for Gnotobiotics, Inc. invites you to join our revitalized organization!! Following many years of inactivity, the current AG council has been working tirelessly to reorganize. In the past year we have had the organization’s incorporation status reinstated with the State of Wisconsin where the organization was first incorporated in 1966. We have also […]

  • Events
    We maintain a calendar of events and meetings related to the field of Microbiome Research. Check it often for new events and conferences, or submit something for the calendar here.

  • Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice


    Significance Studies using experimental models have indicated that multiple sclerosis (MS)-like disease can be triggered in the gut following interactions of brain autoimmune T lymphocytes with local microbiota.

  • BOOK REVIEW: GNOTOBIOTICS


    Gnotobiotics, edited by Trenton Schoeb and Kathryn Eaton, is invaluable to those developing or managing gnotobiotic facilities.

  • Stress could be just as unhealthy as junk food


    Brigham Young University: We all know that a poor diet is unhealthy, but a new BYU study finds that stress may just as harmful to our bodies as a really bad diet.

  • Infection via mosquito bite alters Zika virus replication kinetics in rhesus macaques


    Abstract For more than three decades it has been recognized that small amounts of vector saliva can significantly alter the infectivity of vector-borne pathogens and subsequent in vivo dynamics.

  • Of Mice, Dirty Mice, and Men: Using Mice To Understand Human Immunology


    Abstract Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans.

  • Microbial Genetic Composition Tunes Host Longevity


    Highlights •Systematic analysis of longevity-promoting microbial genetic variations •Colanic acid as a pro-longevity natural compound effective in different species

  • Learning more about the gut microbiota


    The GMFH editing team recommends these book selections on the topic.

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