The Translational Microbiome Research Forum is an online resource for scientists engaged in translational microbiome research to access current, topical information and to provide a platform to exchange knowledge and ideas. We encourage you to participate by actively using the commenting system, by submitting links, resources, and your original research, and by joining our email list to receive updates when new content is posted.

  • Antibiotics weaken signs of Alzheimer’s disease in mice after just one week of treatment
    Postdoctoral Scholar Myles Minter, PhD, and Sangram S. Sisodia, PhD, Director of the Center for Molecular Neurobioloy, pose for a portrait at the University of Chicago on August 18, 2016. They are studying the micro biome in relation to Alzheimer's disease and treatment. (Photo by Eddie Quinones)


    Last year, UChicago neurobiologists Sangram Sisodia and Myles Minter made a surprising discovery: Treating mice with antibiotics long-term reduced some of the telltale signs of Alzheimer’s disease.

  • Multiple sclerosis: What role do gut microbes play?
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    New research investigates the link between the microbial profile of the gut and the development of multiple sclerosis.

  • Gut Germs Appear to Play Role in Multiple Sclerosis
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    Are probiotics for MS next? Two teams of scientists have found the strongest evidence yet that intestinal bacteria play a role in multiple sclerosis, an incurable disease in which the body’s immune system attacks the myelin coating on neurons, causing tremors, fatigue, cognitive problems, and more.

  • Animals Without Gut Microbiomes
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    The human body harbors millions of bacteria in the gut. These resident microbes, in turn, positively affect our health, especially in aiding food digestion.

  • Humanized Mouse Model Market – Detailed Study Analysis and Forecast by 2025
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    A humanized mouse is referred to as a mouse transmitting functioning human organs, tissues, cells, and genes. Humanized mice are basically employed in medical and biological therapeutics as animal models

  • How gut microbes contribute to age-related inflammation
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    Inflammation increases with age and is a strong risk factor for death in the elderly, but the underlying cause has not been clear.

  • The Microbiome and Cancer
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    What are Microbes? Microbes are extremely small living organisms that include bacteria and fungi.

  • Drinks With Mice and the Future of Depression Research
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    Katie Guzzetta ’18 first learned about the gut microbiome while she was in middle school, and has been intrigued ever since.

  • Guardian genes may protect against diabetes by shaping gut flora
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    Around 300 to 500 species of microbial flora inhabit the gut of humans, mice and even insects, and are comprehensively known as the intestinal microbiome.

  • Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer’s disease
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    Abstract Recent evidence suggests the commensal microbiome regulates host immunity and influences brain function; findings that have ramifications for neurodegenerative diseases.

  • High-fat diet increases pain behaviors in rats with or without obesity
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    Abstract Obesity is associated with increased risk for chronic pain. Basic mechanisms for this association are poorly understood.

  • Caterpillars lack a resident gut microbiome
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    Abstract Many animals are inhabited by microbial symbionts that influence their hosts’ development, physiology, ecological interactions, and evolutionary diversification.

  • The Microbiome in Connective Tissue Diseases and Vasculitides: An Updated Narrative Review
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    Abstract Objective. To provide a narrative review of the most recent data concerning the involvement of the microbiome in the pathogenesis of connective tissue diseases (CTDs) and vasculitides.

  • The Gut Microbiome and Its Role in Cardiovascular Diseases
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    The human gastrointestinal tract is predominantly a bacterial ecosystem (microbiome) that harbors >100 trillion microbial cells, with the highest microbe densities found in the colon.

  • The intestinal microbiota determines the colitis-inducing potential of T-bet-deficient Th cells in mice
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    Abstract Conflicting evidence has been provided as to whether induction of intestinal inflammation by adoptive transfer of naïve T cells into Rag−/− mice requires expression of the transcription factor T-bet by the T cells.

  • Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer’s disease
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    Abstract Recent evidence suggests the commensal microbiome regulates host immunity and influences brain function; findings that have ramifications for neurodegenerative diseases.

  • Microbiome Connections to Disease Get Stronger
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    In the pipeline: Derek Lowe’s commentary on drug discovery and the pharma industry. An editorially independent blog from the publishers of Science Translational Medicine. A fair amount of what you read about the human microbiome is hype. There’s no way around it.

  • 2017 MICROBIOME IN MOUSE MODELS WORKSHOP REVIEW — BEST PRACTICES
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    By Philip Dubé, PhD – Part III: Best Practices for Study Design

  • Events
    We maintain a calendar of events and meetings related to the field of Microbiome Research. Check it often for new events and conferences, or submit something for the calendar here.

  • Infection via mosquito bite alters Zika virus replication kinetics in rhesus macaques
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    Abstract For more than three decades it has been recognized that small amounts of vector saliva can significantly alter the infectivity of vector-borne pathogens and subsequent in vivo dynamics.

  • Of Mice, Dirty Mice, and Men: Using Mice To Understand Human Immunology
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    Abstract Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans.

  • Microbial Genetic Composition Tunes Host Longevity
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    Highlights •Systematic analysis of longevity-promoting microbial genetic variations •Colanic acid as a pro-longevity natural compound effective in different species

  • Learning more about the gut microbiota
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    The GMFH editing team recommends these book selections on the topic.

  • Effects of iron supplementation on growth, gut microbiota, metabolomics and cognitive development of rat pups
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    Abstract Background Iron deficiency is common during infancy and therefore iron supplementation is recommended.

  • VIDEO: BioEssays: Brain carnitine deficiency causes nonsyndromic autism with an extreme male bias
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    Arthur Beaudet discusses the importance of diet, genes, epigenetics, drugs, microbiome, and minor illnesses (especially gastrointestinal) in the hypothesis.

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