The Translational Microbiome Research Forum is an online resource for scientists engaged in translational microbiome research to access current, topical information and to provide a platform to exchange knowledge and ideas. We encourage you to participate by actively using the commenting system, by submitting links, resources, and your original research, and by joining our email list to receive updates when new content is posted.

  • The Pit In Your Stomach is Actually Your Second Brain
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    The world is so much bigger and more interesting than we can see with our naked eyes.

  • Does Diet Soda Cause Weight Gain?
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    Artificial sweeteners were designed to keep food and drinks’ sweet taste while doing away with excess sugar’s unwanted effects, such as weight gain, diabetes and metabolic syndrome.

  • Breaking News Antioxidant Could Curb Non-Alcoholic Fatty Liver Disease in Offspring of Obese Mothers
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    PQQ prevented the accumulation of damaging fats in the liver, according to research published in the FASEB Journal.

  • From mice, clues to microbiome’s influence on metabolic disease
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    The community of microorganisms that resides in the gut, known as the microbiome, has been shown to work in tandem with the genes of a host organism to regulate insulin secretion, a key variable in the onset of the metabolic disease diabetes.

  • Melatonin prevents obesity through modulation of gut microbiota in mice
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    Abstract Excess weight and obesity are severe public health threats worldwide.

  • Feeling stressed? Try prebiotics
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    Stress could upset the gut’s microbiome, as well as restful sleep — essential elements for a healthy life.

  • High-Fiber Diet Keeps Intestinal Walls Intact
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    A low-fiber diet causes fiber-eating microbes to dwindle, opening up real estate for mucus munchers that make the intestine more vulnerable to infection. Christopher Intagliata reports.

  • The Secret Lives of Marine Mammal Microbes
    Indo-Pacific bottlenose dolphin. Credit: Aude Steiner Wikimedia (CC BY-SA 1.0)


    Probing the mystery of what goes on inside the guts of dolphins and whales…

  • ADA funds Kostic Lab to create model linking the microbiome to type 1 diabetes
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    The American Diabetes Association (ADA) has awarded Joslin Diabetes Center assistant investigator Aleksandar Kostic, Ph.D., a $1.625-million grant under its Pathway to Stop Diabetes program, which seeks to bring new investigators and new perspectives to diabetes research.

  • C. elegans and its bacterial diet as a model for systems-level understanding of host–microbiota interactions
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    Highlights •C. elegans and its bacterial diet is an excellent model system for mammalian host–microbiota interactions. •C. elegans carries a distinct and species-rich microbiome. •Metabolites produced by bacteria modulate C. elegans life history traits. •Bacterial respiration affects C. elegans development and life span.

  • Early PQQ supplementation has persistent long-term protective effects on developmental programming of hepatic lipotoxicity and inflammation in obese mice
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    Abstract Nonalcoholic fatty liver disease (NAFLD) is widespread in adults and children. Early exposure to maternal obesity or Western-style diet (WD) increases steatosis and oxidative stress in fetal liver and is associated with lifetime disease risk in the offspring.

  • Inhibition of the gut enzyme intestinal alkaline phosphatase may explain how aspartame promotes glucose intolerance and obesity in mice
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    ABSTRACT Diet soda consumption has not been associated with tangible weight loss. Aspartame (ASP) commonly substitutes sugar and one of its breakdown products is phenylalanine (PHE), a known inhibitor of intestinal alkaline phosphatase (IAP), a gut enzyme shown to prevent metabolic syndrome in mice.

  • Therapeutic modulation of gut microbiota in inflammatory bowel disease: More questions to be answered
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    Abstract Patients with inflammatory bowel disease (IBD) exhibit impaired control of the microbiome in the gut, and ‘dysbiosis’ is commonly observed.

  • Host Genotype and Gut Microbiome Modulate Insulin Secretion and Diet-Induced Metabolic Phenotypes
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    Highlights •Host genotype affects the abundance of taxa associated with metabolic disease •Gut microbiota affects susceptibility to diet-induced metabolic disease •The gut microbiome modulates insulin secretion

  • Host Genotype and Gut Microbiome Modulate Insulin Secretion and Diet-Induced Metabolic Phenotypes
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    Highlights •Host genotype affects the abundance of taxa associated with metabolic disease •Gut microbiota affects susceptibility to diet-induced metabolic disease •The gut microbiome modulates insulin secretion

  • A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility
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    Highlights •Characterized synthetic bacterial communities enable functional insights in vivo •Low-fiber diet promotes expansion and activity of colonic mucus-degrading bacteria •Purified prebiotic fibers do not alleviate degradation of the mucus layer •Fiber-deprived gut microbiota promotes aggressive colitis by an enteric pathogen

  • Human and rat gut microbiome composition is maintained following sleep restriction

    Abstract Insufficient sleep increasingly characterizes modern society, contributing to a host of serious medical problems.

  • Microbiota composition of simultaneously colonized mice housed under either a gnotobiotic isolator or individually ventilated cage regime
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    Abstract Germ-free rodents colonized with microbiotas of interest are used for host-microbiota investigations and for testing microbiota-targeted therapeutic candidates.

  • Antigen-Microarray Profiling of Antibodies in SLE: A Personal View of Translation from Basic Science to the Clinic
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    Irun R. Cohen, Professor of Immunology, Emeritus, The Weizmann Institute of Science Abstract In October of 2015, the startup company ImmunArray announced the launch of a microarray platform – the iChip® – to profile repertoires of serum antibodies and autoantibodies.

  • What We’ve Learned From Studying Microbiomes
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    By Dr. Bill Van Bonn, Vice President of Animal Health at Shedd Aquarium. Specializes in preventive medicine and clinical veterinary services for aquatic animals: What is a microbiome you ask? It’s the tiny living community that surrounds us all and is the subject of investigation by human and veterinary health care providers everywhere.

  • Events
    We maintain a calendar of events and meetings related to the field of Microbiome Research. Check it often for new events and conferences, or submit something for the calendar here.

  • VIDEO: What If You Had A Second Brain?
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    AsapScience, stylized as AsapSCIENCE, is a YouTube channel created by Canadian youtubers Mitchell Moffit and Gregory Brown. The channel produces weekly videos that touch on many different topics of science. Check Out Here: AsapSCIENCE

  • Home-Made Cost Effective Preservation Buffer Is a Better Alternative to Commercial Preservation Methods for Microbiome Research
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    The investigation of wildlife gastrointestinal microbiomes by next-generation sequencing approaches is a growing field in microbial ecology and conservation.

  • Free Webinar: Precision Medicine – Learning Lessons From the Microbiome
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    Summary The influence of gut microbiota on human health has been well documented, particularly in the case of metabolic disorders, such as type 1 and type 2 diabetes.

  • VIDEO: Native squid and its bacterium may help human and environmental health
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    The humble Hawaiian bobtail squid is helping to build the University of Hawaiʻi’s capacity in the hot field of microbiome research.

  • VIDEO: Precision Medicine: Learning Lessons From the Microbiome
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    Summary The influence of gut microbiota on human health has been well documented, particularly in the case of metabolic disorders, such as type 1 and type 2 diabetes.

  • ILAR Roundtable workshop on Animal Models for Microbiome Research
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    Video recordings and presentations from the ILAR Roundtable workshop on Animal Models for Microbiome Research held on December 19-20, 2016: See more at: ILAR Roundtable

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