The Translational Microbiome Research Forum is an online resource for scientists engaged in translational microbiome research to access current, topical information and to provide a platform to exchange knowledge and ideas. We encourage you to participate by actively using the commenting system, by submitting links, resources, and your original research, and by joining our email list to receive updates when new content is posted.

  • New links between gut microbiota and multiple sclerosis

    Blurred or double vision; numbness in the arms, legs, or face; problems with balance when walking. These are some of the first symptoms of multiple sclerosis (MS),

  • Harvard group engineers bacteria with a ‘memory’ for gut inflammation in mice

    Bacteria are responsive to the environment within the mammalian gut.

  • Endomicroscopy Offers Insight on Leaky Gut Syndrome

    The concept of “leaky gut,” or intestinal hyperpermeability remains one of the more controversial digestive health issues of the last 20 years.

  • Possible Link Between Carnitine Deficiency and Autism

    Summary: Researchers report a lack of a nutrient required for normal brain development may trigger a mild form of autism. The findings, published in BioEssays, suggests supplementing the diet with carnitine could prevent up to 20% of autism cases.

  • Tata Chemicals provides glimpse to future production of food supplements

    Visitors to the Tata Chemicals Innovation Centre in Pune are not always given Power Point presentations. But they are certainly given stuff to eat, usually snacks that the company has not yet launched.

  • Gut bacteria can help to predict how the body will respond to fatty foods

    Scientists have found that certain compounds, produced by microbes in the guts of mice, could be used to show which animals are at greater risk of becoming obese or developing health conditions such as diabetes or cardiovascular disease.

  • Diabetes Causes Shift in Oral Microbiome That Fosters Periodontitis, Penn Study Finds
    Graves oral microbiome

    A new study led by University of Pennsylvania researchers has found that the oral microbiome is affected by diabetes, causing a shift to increase its pathogenicity.

  • Eye-dwelling bacteria help mice fight off invading pathogens

    The surface of the eye is one of the most inhospitable environments for microbes in the mammalian body, because tears are loaded with anti-microbials.

  • Antibiotic use during peripartum period linked to greater risk of inflammatory condition in offspring

    A study by researchers at the University of Chicago Medicine shows that when mice that are genetically susceptible to developing inflammatory bowel disease (IBD) were given antibiotics during late pregnancy and the early nursing period,

  • Lipopolysaccharide Binding Protein and Oxidative Stress in a Multiple Sclerosis Model.

    Abstract Recent findings in experimental autoimmune encephalomyelitis (EAE) suggest that altering certain bacterial populations present in the gut may lead to a proinflammatory condition, that could result in the development of multiple sclerosis (MS). Also, Reactive Oxygen Species seem to be involved in the course of MS. In this study, it has been aimed to […]

  • Progress toward an integrated understanding of Parkinson’s disease

    Abstract Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s disease, affecting over 10 million individuals worldwide.

  • Peripartum Antibiotics Promote Gut Dysbiosis, Loss of Immune Tolerance, and Inflammatory Bowel Disease in Genetically Prone Offspring

    Highlights •Peripartum antibiotics promote offspring gut dysbiosis, immune dysfunction, and IBD •Antibiotics given after the developmental period do not increase IBD

  • Brain carnitine deficiency causes nonsyndromic autism with an extreme male bias: A hypothesis
    cover (1)

    Abstract Could 10–20% of autism be prevented? We hypothesize that nonsyndromic or “essential” autism involves extreme male bias in infants who are genetically normal, but they develop deficiency of carnitine and perhaps other nutrients in the brain causing autism that may be amenable to early reversal and prevention.

  • An Ocular Commensal Protects against Corneal Infection by Driving an Interleukin-17 Response from Mucosal γδ T Cells
    Final Figures

    Highlights •Corynebacterium mastitidis colonizes the mouse conjunctiva •C. mastitidis induces interleukin-17 production from mucosal γδ T cells •Introduction of the commensal to mice that lack it protects the eye from infection •Topical antibiotics cause the ocular surface to be more susceptible to infection

  • Western Diet–Induced Dysbiosis in Farnesoid X Receptor Knockout Mice Causes Persistent Hepatic Inflammation after Antibiotic Treatment

    Patients who have liver cirrhosis and liver cancer also have reduced farnesoid X receptor (FXR). The current study analyzes the effect of diet through microbiota that affect hepatic inflammation in FXR knockout (KO) mice.

  • Microbial-Host Co-metabolites Are Prodromal Markers Predicting Phenotypic Heterogeneity in Behavior, Obesity, and Impaired Glucose Tolerance

    Highlights •High-fat diet drives phenotypic heterogeneity in metabolism and behavior •Microbial metabolites, including methylamines, predict phenotypic heterogeneity

  • Diabetes Enhances IL-17 Expression and Alters the Oral Microbiome to Increase Its Pathogenicity
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    Highlights •Diabetes increases periodontal bone resorption and tooth loss in mice •Diabetic mice have increased periodontal inflammation and IL-17 levels

  • Will gut microbiota provide the solution to all of our health problems?

    Professor Patrice D. Cani is researcher from the Belgian Fund for Scientific Research (FRS-FNRS): Conditions that represent some of the leading causes of mortality worldwide—including obesity, diabetes, cardiovascular disease, and cancers

  • GUT CHECK Why a Cure to Obesity Could Be in Your Poop

    Paul A. Offit (…director of the Vaccine Education Center at the Children’s Hospital of Philadelphia and the author of Pandora’s Lab: Seven Stories of Science Gone Wrong [National Geographic Press, 2017]): Scientists recently found something remarkable in the microbiomes of human twins and mice with a filthy habit.

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    We maintain a calendar of events and meetings related to the field of Microbiome Research. Check it often for new events and conferences, or submit something for the calendar here.

  • VIDEO: BioEssays: Brain carnitine deficiency causes nonsyndromic autism with an extreme male bias

    Arthur Beaudet discusses the importance of diet, genes, epigenetics, drugs, microbiome, and minor illnesses (especially gastrointestinal) in the hypothesis.

  • From complex gut communities to minimal microbiomes via cultivation

    Highlights •Microbiome research will benefit from the complementary use of culture and molecular approaches.

  • Detection of Helicobacter pylori in the Gastric Mucosa by Fluorescence In Vivo Hybridization

    Abstract In this chapter, we describe a fluorescence in vivo hybridization (FIVH) protocol, using nucleic acid probes, for the detection of the bacterium Helicobacter pylori in the gastric mucosa of an infected C57BL/6 mouse model.


    A periodic list of methods, tools and people driving research and development. Our scientists present 10 tools and strategies helping to advance immuno-oncology

  • Harnessing the Power of PCR Molecular Fingerprinting Methods and Next Generation Sequencing for Understanding Structure and Function in Microbial Communities

    Abstract Polymerase chain reaction (PCR) is central to methods in molecular ecology. Here, we describe PCR-dependent approaches useful for investigating microbial diversity and its function in various natural, human-associated, and built environment ecosystems.

  • Involvement of a gut–retina axis in protection against dietary glycemia-induced age-related macular degeneration

    Significance Food is medicine, and diet impacts the risk for and progression of age-related macular degeneration AMD, but we have few clues as to why. We found that wild-type mice fed a high-glycemic-index diet similar in composition to the Western diet developed a disease state that resembles dry AMD.

  • SteadyCom: Predicting microbial abundances while ensuring community stability

    Abstract Genome-scale metabolic modeling has become widespread for analyzing microbial metabolism. Extending this established paradigm to more complex microbial communities is emerging as a promising way to unravel the interactions and biochemical repertoire of these omnipresent systems.

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