The Translational Microbiome Research Forum is an online resource for scientists engaged in translational microbiome research to access current, topical information and to provide a platform to exchange knowledge and ideas. We encourage you to participate by actively using the commenting system, by submitting links, resources, and your original research, and by joining our email list to receive updates when new content is posted.

  • A New Antibiotic Weakness—Drugs Themselves Help Bacteria Survive

    Antibiotics save lives, but they are not fail-safe. Even when microbes haven’t acquired drug-evading genetic mutations—a hallmark of antibiotic resistance—the medications don’t always clear infections. A new study identifies a surprising reason why: At infection sites, antibiotics change the natural mixture of chemicals made by the body in ways that protect infecting bacteria. They also […]

  • TH17-INDUCING GUT BACTERIA CAN PROMOTE AUTISM-LIKE BEHAVIOR IN MOUSE PUPS
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    On September 13, 2017 researchers from the Massachusetts Institute of Technology and the University of Massachusetts Medical School simultaneously published papers in Nature on the same intriguing topic: a link between autism and infection during pregnancy.

  • Gut bacteria could determine whether you develop PTSD
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    Molecular Biologists found that you’re more likely to develop PTSD if you lack in certain immune supporting bacteria

  • Gut microbes could help trigger multiple sclerosis
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    The trillions of bacteria that live in our intestines, known collectively as the gut microbiome, have been linked to maladies from eye disease to rheumatoid arthritis. Now, two new studies have added another disease: multiple sclerosis (MS)

  • The Next Big Performance Enhancing Drug: Bacteria From Elite Athletes’ Guts?
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    When Jonathan Scheiman describes his lab as “a lot of crazy shit,” he’s not kidding. For the last three years, the 35-year-old molecular biologist has been working at Harvard University studying the, um, stool of pro marathoners, ultra- runners, and Olympic rowers.

  • Two new studies support the link between the gut microbiome and multiple sclerosis
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    Previous research has found that multiple sclerosis (MS) patients may have a specific microbial signature in their gut microbiota that could impact disease pathogenesis.

  • Global Human Microbiome Market Size and Forecast to 2021
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    Description: Human Microbiome Report by Material, Application, and Geography — Global Forecast to 2021 is a professional and comprehensive research report on the world’s major regional market conditions, focusing on the main regions (North America, Europe and Asia-Pacific) and the main countries (United States, Germany, United Kingdom,Japan, South Korea and China).

  • Enterome’s EB8018, a First-in-class Drug Candidate Targeting Crohn’s Disease, Successfully Completes Phase I Study in Healthy Volunteers
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    ENTEROME SA, a pioneer of innovative therapies for microbiome-related diseases, is pleased to announce the successful completion of the first Phase 1 clinical study with its lead candidate EB8018, a small molecule designed to block FimH, as a potential new orally-administered treatment for Crohn’s disease.

  • Scientists investigate the ‘black box’ of bacterial effects on the brain and behaviour
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    Researchers from McMaster University (Canada) had a clear question in mind when they conducted their recent experiment: if a mouse had its gut microbiota altered by antibiotics in early life, what would happen to its brain?

  • Removal of the cecum affects intestinal fermentation, enteric bacterial community structure, and acute colitis in mice

    ABSTRACT The murine cecum is a major site of fermentation of dietary materials, and production of short chain fatty acids (SCFAs). To examine the role that the cecum plays in acute bacterial infection in mice, the cecum was surgically removed, and changes in bacterial communities and production of SCFAs were analyzed relative to surgical sham […]

  • Deficiency of essential dietary n-3 PUFA disrupts the caecal microbiome and metabolome in mice

    ABSTRACT n-3 PUFA are lipids that play crucial roles in immune-regulation, cardio-protection and neurodevelopment. However, little is known about the role that these essential dietary fats play in modulating caecal microbiota composition and the subsequent production of functional metabolites. To investigate this, female C57BL/6 mice were assigned to one of three diets (control (CON), n-3 […]

  • Antibiotic-Induced Changes to the Host Metabolic Environment Inhibit Drug Efficacy and Alter Immune Function

    ABSTRACT Bactericidal antibiotics alter microbial metabolism as part of their lethality and can damage mitochondria in mammalian cells. In addition, antibiotic susceptibility is sensitive to extracellular metabolites, but it remains unknown whether metabolites present at an infection site can affect either treatment efficacy or immune function. Here, we quantify local metabolic changes in the host […]

  • Simultaneous delivery of antibiotics neomycin and ampicillin in drinking water inhibits fermentation of resistant starch in rats

    ABSTRACT Scope Antibiotics ampicillin 1 g/L and neomycin 0.5 g/L were added to drinking water before or during feeding of resistant starch (RS) to rats to inhibit fermentation. Methods and results In a preliminary study, antibiotics and no RS were given prior to rats receiving a transplant of cecal contents via gavage from donor rats […]

  • Intergenerational transfer of antibiotic-perturbed microbiota enhances colitis in susceptible mice

    ABSTRACT Antibiotic exposure in children has been associated with the risk of inflammatory bowel disease (IBD). Antibiotic use in children or in their pregnant mother can affect how the intestinal microbiome develops, so we asked whether the transfer of an antibiotic-perturbed microbiota from mothers to their children could affect their risk of developing IBD. Here […]

  • The Gastrointestinal Microbiome: A Review

    ABSTRACT The gastrointestinal microbiome is a diverse consortium of bacteria, archaea, fungi, protozoa, and viruses that inhabit the gut of all mammals. Studies in humans and other mammals have implicated the microbiome in a range of physiologic processes that are vital to host health including energy homeostasis, metabolism, gut epithelial health, immunologic activity, and neurobehavioral […]

  • Brown rice and retrograded brown rice alleviate inflammatory response in dextran sulfate sodium (DSS)-induced colitis mice

    ABSTRACT The present study was aimed to investigate the impacts of brown rice (BR) and retrograded brown rice (R-BR) consumption on colonic health and gut microbiota in dextran sulfate sodium (DSS) induced colitis mice. Thirty two female C57Bl/6Mlac mice were fed with modified AIN 93G diets by replacing cornstarch in the original composition with white […]

  • Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models

    ABSTRACT We have experimentally investigated the immunoregulatory effects of human gut microbiota in multiple sclerosis (MS). We have identified specific bacteria that are associated with MS and demonstrated that these bacteria regulate T lymphocyte-mediated adaptive immune responses and contribute to the proinflammatory environment in vitro and in vivo. Thus, our results expand the knowledge of […]

  • Multi-omics Comparative Analysis Reveals Multiple Layers of Host Signaling Pathway Regulation by the Gut Microbiota
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    ABSTRACT The bodies of mammals are hosts to vast microbial communities composed of trillions of bacteria from thousands of species, whose effects on health and development have begun to be appreciated only recently.

  • Growing Roster of Speakers, Spanning Research and Industry, Announced for 4th Annual Translational Microbiome Conference

    Contact: John Waslif, Managing Director, Arrowhead Publishers and Conferences Phone: 866-945-0263 (extension 700) Email: john.waslif@arrowheadpublishers.com Website: arrowheadpublishers.com Conference topics will feature speakers and panels on animal models, bioinformatics challenges, intellectual property management, investment deals and approaches, pharma deals in the microbiome space, and the need for standards. MINNEAPOLIS, November 28, 2017– Arrowhead Publishers unveils a […]

  • Microbiome Drug Development Event

    Despite increased investment, there are still major challenges generating effective pre-clinical data and translating that into the clinic; including building an effective CMC strategy that allows a realistic scale-up. Another major challenge is navigating the regulatory landscape in Europe which is becoming increasingly difficult and has even resulted in companies setting up offices in the […]

  • Events
    We maintain a calendar of events and meetings related to the field of Microbiome Research. Check it often for new events and conferences, or submit something for the calendar here.

  • Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice
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    Significance Studies using experimental models have indicated that multiple sclerosis (MS)-like disease can be triggered in the gut following interactions of brain autoimmune T lymphocytes with local microbiota.

  • BOOK REVIEW: GNOTOBIOTICS
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    Gnotobiotics, edited by Trenton Schoeb and Kathryn Eaton, is invaluable to those developing or managing gnotobiotic facilities.

  • Stress could be just as unhealthy as junk food
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    Brigham Young University: We all know that a poor diet is unhealthy, but a new BYU study finds that stress may just as harmful to our bodies as a really bad diet.

  • Infection via mosquito bite alters Zika virus replication kinetics in rhesus macaques
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    Abstract For more than three decades it has been recognized that small amounts of vector saliva can significantly alter the infectivity of vector-borne pathogens and subsequent in vivo dynamics.

  • Of Mice, Dirty Mice, and Men: Using Mice To Understand Human Immunology
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    Abstract Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans.

  • Microbial Genetic Composition Tunes Host Longevity
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    Highlights •Systematic analysis of longevity-promoting microbial genetic variations •Colanic acid as a pro-longevity natural compound effective in different species

  • Learning more about the gut microbiota
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    The GMFH editing team recommends these book selections on the topic.

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