The Translational Microbiome Research Forum is an online resource for scientists engaged in translational microbiome research to access current, topical information and to provide a platform to exchange knowledge and ideas. We encourage you to participate by actively using the commenting system, by submitting links, resources, and your original research, and by joining our email list to receive updates when new content is posted.

  • Understanding how pain is bugging you
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    Scientists at the Science Foundation Ireland-funded APC Microbiome Institute at University College Cork, Ireland, have shown that, at least in mice, gut bacteria play a key role in regulating abdominal pain and its associated changes in the brain and spinal cord.

  • Crohn’s Disease Severity Amplified by Fungus
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    Inflammatory bowel disease (IBD) affects millions worldwide and can often lead to serious intestinal disorders if left unchecked.

  • Gut microbiota – Tiny helpers against Samonella
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    HZI scientists discover immune mechanism against Salmonella in the mucosa of the gut

  • Lemur research gets a gut check
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    “Stool sample collector” is not a glamorous way to introduce oneself at a party. But in the course of their research, gut microbiologists Erin McKenney and Lydia Greene have spent a lot of time waiting for animals to relieve themselves.

  • Study details impact of antibiotics, antiseptics on skin microbiomes
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    The use of topical antibiotics can dramatically alter communities of bacteria that live on the skin, while the use of antiseptics has a much smaller, less durable impact.

  • Irritable bowel pain may soon be cured following 10-year study at UCC
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    Scientists may soon be able to alleviate the stomach pain of thousands of sufferers of irritable bowel syndrome by controlling the bacteria in the gut, according to pioneering Irish research.

  • $10 million gift boosts gut microbiome research at Wash U
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    A $10 million gift to Washington University School of Medicine will help advance the understanding of how microbes that colonize the human gut can impact human health, the university announced this week.

  • Is Less More?
    editorial


    Still life is an art form whose popularity stretches back to the roots of human civilization. Depictions of food often feature prominently in wall paintings in ancient Egyptian tombs and are common in Roman mosaics and frescos.

  • Metformin joins forces with gut microbes to improve blood sugars, new study finds
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    Researchers at the University of Gothenburg and the Institute of Biomedical Investigation of Girona have found that gut microbial shifts under metformin treatment contribute to improved blood sugar control.

  • Long-term consumption of caffeine-free high sucrose cola beverages aggravates the pathogenesis of EAE in mice
    13898781-Mascot-Illustration-Featuring-a-Soda-Can-Stock-Illustration-cartoon


    Abstract Epidemiological data provide strong evidence of dramatically increasing incidences of many autoimmune diseases in the past few decades, mainly in western and westernized countries.

  • Factors Influencing the Gut Microbiota, Inflammation, and Type 2 Diabetes
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    Abstract The gut microbiota is a complex community of bacteria residing in the intestine. Animal models have demonstrated that several factors contribute to and can significantly alter the composition of the gut microbiota, including

  • Potassium is a key signal in host-microbiome dysbiosis in periodontitis
    journal.ppat.1006457.g001


    Abstract Dysbiosis, or the imbalance in the structural and/or functional properties of the microbiome, is at the origin of important infectious inflammatory diseases such as inflammatory bowel disease (IBD) and periodontal disease.

  • The development of lower respiratory tract microbiome in mice
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    Abstract Background Although culture-independent methods have paved the way for characterization of the lung microbiome, the dynamic changes in the lung microbiome from neonatal stage to adult age have not been investigated.

  • Differing Complex Microbiota Alter Disease Severity of the IL-10−/− Mouse Model of Inflammatory Bowel Disease
    PowerPoint Presentation


    It is estimated that 1.4 million people in the United States suffer from Inflammatory Bowel Disease (IBD), with an overall annual health care cost of more than $1.7 billion.

  • Probabilistic Invasion Underlies Natural Gut Microbiome Stability
    Graphical_Abstract_v3b


    Highlights •Establishment of commensal bacteria in the gut works like a lottery •Stochastic factors generate alternate stable states of gut colonization

  • Enhancement of IFNγ Production by Distinct Commensals Ameliorates Salmonella-Induced Disease
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    Highlights •Microbiota composition determines susceptibility to Salmonella-induced disease •Protection is associated with decreased tissue invasion of Salmonella

  • Impact of maintenance immunosuppressive therapy on the fecal microbiome of renal transplant recipients: Comparison between an everolimus- and a standard tacrolimus-based regimen
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    Highlights •Interactions between animal hosts and their microbiota occur at multiple scales. •The zebrafish is a powerful model to study many scales of host–microbe interactions.

  • A psychology of the human brain–gut–microbiome axis
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    In recent years, we have seen increasing research within neuroscience and biopsychology on the interactions between the brain, the gastrointestinal tract, the bacteria within the gastrointestinal tract, and the bidirectional relationship between these systems:

  • The Florence Statement on Triclosan and Triclocarban
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    SUMMARY: The Florence Statement on Triclosan and Triclocarban documents a consensus of more than 200 scientists and medical professionals on the hazards of and lack of demonstrated benefit from common uses of triclosan and triclocarban.

  • The bug hunters and the microbiome
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    Trevor Lawley and Gordon Dougan are bug hunters, albeit not the conventional kind.

  • Events
    We maintain a calendar of events and meetings related to the field of Microbiome Research. Check it often for new events and conferences, or submit something for the calendar here.

  • From complex gut communities to minimal microbiomes via cultivation
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    Highlights •Microbiome research will benefit from the complementary use of culture and molecular approaches.

  • Detection of Helicobacter pylori in the Gastric Mucosa by Fluorescence In Vivo Hybridization
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    Abstract In this chapter, we describe a fluorescence in vivo hybridization (FIVH) protocol, using nucleic acid probes, for the detection of the bacterium Helicobacter pylori in the gastric mucosa of an infected C57BL/6 mouse model.

  • TOOLS AND TRENDS IN IMMUNO-ONCOLOGY
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    A periodic list of methods, tools and people driving research and development. Our scientists present 10 tools and strategies helping to advance immuno-oncology

  • Harnessing the Power of PCR Molecular Fingerprinting Methods and Next Generation Sequencing for Understanding Structure and Function in Microbial Communities
    978-1-4939-7060-5


    Abstract Polymerase chain reaction (PCR) is central to methods in molecular ecology. Here, we describe PCR-dependent approaches useful for investigating microbial diversity and its function in various natural, human-associated, and built environment ecosystems.

  • Involvement of a gut–retina axis in protection against dietary glycemia-induced age-related macular degeneration
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    Significance Food is medicine, and diet impacts the risk for and progression of age-related macular degeneration AMD, but we have few clues as to why. We found that wild-type mice fed a high-glycemic-index diet similar in composition to the Western diet developed a disease state that resembles dry AMD.

  • SteadyCom: Predicting microbial abundances while ensuring community stability
    journal.pcbi.1005539.g001


    Abstract Genome-scale metabolic modeling has become widespread for analyzing microbial metabolism. Extending this established paradigm to more complex microbial communities is emerging as a promising way to unravel the interactions and biochemical repertoire of these omnipresent systems.

  • Optical nanofiber ‘hears’ bacteria swim, cancer cells move
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    At the macroscopic level that’s familiar to us, birds chirp, whales sing and we talk. But at the microscopic level, our cells pulsate, bacteria swim and pressure waves ripple on a scale we can’t reach.

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