The microbiome continues to be an important topic in both human health research and in popular culture. The microbiome is cited as a factor in multiple diseases, neurological conditions, and immune responses to foreign pathogens. Specific compositions of gut commensal bacteria have been associated with an increased incidence of depression, varying responses to immunotherapies, and […]
The microbiome consists of about 100 trillion microbes (microbiota) and their genomes. These are made of bacteriophage, fungi, bacteria, protozoa (single-cell eukaryotes), and viruses in the human body. They play an important role in health maintenance systems of the immune system, as well as in drugs and foreign substances (xenobiotics) metabolism. Researchers have discovered that […]
UT Southwestern researchers have found a key driver of the crosstalk that helps synchronize the absorption of nutrients in the gut with the rhythms of the Earth’s day-night light cycle. Their findings could have far-ranging implications for obesity in affluent countries and malnutrition in impoverished countries. In the study, Dr. Lora Hooper and her research […]
Mice (and maybe people) may metabolize food according to daily, circadian rhythms set by gut bacteria. Microbes in the small intestine of mice rhythmically dictate when fat is taken up by cells that line the organ, researchers report. The study, described in the Sept. 27 Science, details how gut microbes influence a host’s metabolism. If […]
A recent study published in Nature Medicine reports on the correlation between rigorous exercise and the increase in abundance of a specific bacterial genus in the human gut microbiome. The collaborative group, which includes CRISPR-researcher George Church from Harvard Medical School, established a connection between the abundance of Veillonella atypica and an increased ability to […]
Taconic Biosciences’ Marina Hanson DVM, PhD presents this exclusive webinar where she describes how TruBIOME™ enables the generation and maintenance of mice with defined custom microbiome profiles, including insight into the Wild Mouse gut microbiota. Watch today to learn: About the Wild Mouse gut microbiome and how it varies from the microbiota of standard laboratory […]
The tools of chemical biology, genomics and data mining can yield insights into the metabolites of the microbiome. Studies of the microorganisms that live on and inside animals’ bodies have long relied on DNA sequencing, which can reveal which species abound and how these microbial communities respond to their environment. Now, the analytical methods of […]
The Human Microbiome Project’s former Program Coordinator, Lita Proctor, set out priorities for the next ten years of human microbiome research in a wide-ranging article for Nature. She also provides reflections on the completed Human Microbiome Project that helped jump-start microbiome research in the US and beyond. In the past ten years microbiome research has […]
Resulting Studies Will Provide Critical Reference Data to Drive Advancements in Human Health Rensselaer, NY — September 3, 2019 – Taconic Biosciences, a global leader in providing genetically engineered animal model solutions, announces its participation in the second Rodent Research Reference (RRR) mission to the International Space Station. Taconic has a history with NASA dating […]
Summary Fecal transfer from healthy donors is being explored as a microbiome modality. MicroRNAs (miRNAs) have been found to affect the microbiome. Multiple sclerosis (MS) patients have been shown to have an altered gut microbiome. Here, we unexpectedly found that transfer of feces harvested at peak disease from the experimental autoimmune encephalomyelitis (EAE) model of […]
Abstract The capacity of the colon to absorb microbially-produced amino acids (AAs) and the underlying mechanisms of AA transport are incompletely defined. We measured the profile of 16 fecal AAs along the rat ceco-colonic axis and compared unidirectional absorptive AA fluxes across mucosal tissues isolated from the rat jejunum, cecum, and proximal colon using an […]
Background Changes in the gut microbiota have been implicated in mood and cognition. In rodents, supplementation with certain bacteria have been shown to alleviate adverse effects of stress on gut microbiota composition and behaviour, but little is known of how the performance of different strains compare to each other. We took a systematic approach to […]
Significance This study advances our appreciation and understanding of the role of colon dysbiosis in the pathogenesis of colorectal cancer. In a human pilot study of 266 individuals, greater epigenomic (methylation) DNA alterations correlated with CRC and microbiota composition. Beyond this correlative evidence, when germ-free mice received fresh feces from CRC patients and their healthy […]
Significance People with multiple sclerosis have a microbiota distinct from healthy controls, and there is growing interest in how these differences might contribute to the onset and progression of CNS autoimmunity. However, the impact that the microbiota may also have on the endogenous regeneration of myelin—remyelination—has not yet been explored. Here we show that inflammatory […]
Hidden benefits of a fecal transplant Our gut microbiota evolves as we age, yet its effects on host physiology are not clearly understood. Kundu et al. now attempt to elucidate these effects by transplanting the gut microbiota of either young or old donor mice into young germ-free recipient mice. They report that young germ-free mice […]
ABSTRACT Vasoactive intestinal peptide (VIP) is crucial for gastrointestinal tract (GIT) health. VIP sustains GIT homeostasis through maintenance of the intestinal epithelial barrier and acts as a potent anti-inflammatory mediator that contributes to gut bacterial tolerance. Based on these biological functions by VIP, we hypothesized that its deficiency would alter gut microbial ecology. To this […]
Vasoactive intestinal peptide (VIP) is crucial for gastrointestinal tract (GIT) health. VIP sustains GIT homeostasis through maintenance of the intestinal epithelial barrier and acts as a potent anti-inflammatory mediator that contributes to gut bacterial tolerance. Based on these biological functions by VIP, we hypothesized that its deficiency would alter gut microbial ecology. To this end, […]
ABSTRACT BACKGROUND Watermelon intake has demonstrated effects on blood pressure regulation along with other health benefits. OBJECTIVE We hypothesized that intake of whole watermelon and products made from watermelon rind (WR) and watermelon skin (WS) would remediate metabolic complications in C57BL/6 J male mice fed a diet modeling a Western-style diet. METHODS Ten-week-old male C57BL/6 […]
Significance Studies using experimental models have indicated that multiple sclerosis (MS)-like disease can be triggered in the gut following interactions of brain autoimmune T lymphocytes with local microbiota.
Gnotobiotics, edited by Trenton Schoeb and Kathryn Eaton, is invaluable to those developing or managing gnotobiotic facilities.
Brigham Young University: We all know that a poor diet is unhealthy, but a new BYU study finds that stress may just as harmful to our bodies as a really bad diet.
Abstract For more than three decades it has been recognized that small amounts of vector saliva can significantly alter the infectivity of vector-borne pathogens and subsequent in vivo dynamics.
Abstract Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans.
Highlights •Systematic analysis of longevity-promoting microbial genetic variations •Colanic acid as a pro-longevity natural compound effective in different species