The Translational Microbiome Research Forum is an online resource for scientists engaged in translational microbiome research to access current, topical information and to provide a platform to exchange knowledge and ideas. We encourage you to participate by actively using the commenting system, by submitting events, and by joining our email list to receive updates when new content is posted.

  • University of Calgary to lead pan-Canadian microbiome research core

    The microbiome has an impact on every organ in the body. It is associated with every chronic disease that affects humans. For the past few years, research has focused on cataloguing what microbes are present on and in our bodies, and connecting those microbes to specific diseases. The next step is to find out how […]

  • Overcoming Challenges in the Clinical Development of Nutrition-Related Microbiome Interventions

    Arrowhead Publishers has announced the return of their Nutrition track, sponsored by Reckitt Benckiser, to the 5th Annual Translational Microbiome Conference. This year’s nutrition track will have two complementary goals: to address the challenges faced by industry when undergoing clinical development for a microbiome-based intervention and current advances in the research, production and use of […]

  • Transforming medicine with the microbiome


    ABSTRACT The study of microorganisms has been revolutionized by complementing the centuries-old art of microbiology with next-generation sequencing of complex bacterial communities (collectively termed “the microbiome”) within and around the eukaryotic host. Microbiome research initially focused on associations between certain microbial compositional features and human medical conditions. The field has quickly evolved, unraveling causative links […]

  • Jeffrey Gordon wins the Frontiers of Knowledge Award for pioneering microbiome research


    The BBVA Foundation Frontiers of Knowledge Award in the Biology and Biomedicine category has gone in this eleventh edition to American researcher Jeffrey Gordon, for his fundamental discovery of the importance of the gut microbial community to human health, in the words of the committee. “Gordon and his team were the first to demonstrate the […]

  • Rederivation of Mouse Models at Higher Health Statuses


    Rederiving murine research models is the process of transferring embryos from one animal into another which is either germ-free or hosts only specifically identified microbiota. This “resets” the health status of the line, allowing the offspring of mice or rats that were previously infected with either viruses, parasites, or bacteria to be used in research […]

  • The Secrets of Successful Venture Pitching: A New Workshop at the 5th Annual Translational Microbiome Conference

    An important new workshop is taking place at the 5th Annual Translational Microbiome Conference (Boston | April 16-18, 2019). Dr. Lakshmi Balanchandra, the Founder of the Women’s Venture Capital Network and an Assistant Professor of Entrepreneurship at Babson College’s Blank Center for Entrepreneurship, will be presenting What Investors Want, What Investors Notice and Value in […]

  • The most significant achievements in gut microbiome science in 2018


    In 2018, the Gut Microbiota for Health (GMFH) digital community has reached an audience that includes scientists, healthcare professionals, and the general public, with 60,000 visits every month from all over the world. These changes reflect an increased awareness of how the gut microbiome influences health. Meanwhile, the number of publications focusing on the gut […]

  • Bacteria Making Headlines in 2018


    In the last few months, multiple bacterial species have been making headlines. This review will outline three types of bacteria and how specific strains may prevent or encourage the development of bacterial infections: Escherichia coli (E. coli) is a gram-negative bacteria part of the Enterobacteriaceae family. E. coli in the Microbiome – Harmless strains of […]

  • Seasonal Cycling in the Gut Microbiome of the Hadza Hunter-gatherers of Tanzania


    Researchers from Stanford University published a paper in Science titled “Seasonal cycling in the gut microbiome of the Hadza hunter-gatherers of Tanzania” which examines the relationship between diet, seasons, and the microbiome. The authors performed a longitudinal study on 350 stool samples collected throughout a year and a half and found that the microbial population […]

  • The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible Effect on the Murine Gut Microbiome


    Abstract Acarbose is a safe and effective medication for type 2 diabetes that inhibits host glucoamylases to prevent starch digestion in the small intestines and thus decrease postprandial blood glucose levels. This results in an increase in dietary starch in the distal intestine, where it becomes food for the gut bacterial community. Here, we examined […]

  • Testosterone disruptor effect and gut microbiome perturbation in mice: Early life exposure to doxycycline


    ABSTRACT Veterinary tetracycline drugs are emerging organic pollutants detected at high concentrations in the urine of school children and a potential public health risk. However, the implications of early-life exposure to tetracyclines on testosterone production, being new endocrine disruptors, remain unknown. We investigated whether the early-life exposure to low-doxycycline, a widely used tetracycline, on mitochondria […]

  • Synbiotic-driven improvement of metabolic disturbances is associated with changes in the gut microbiome in diet-induced obese mice


    ABSTRACT Objective The gut microbiota is an important influencing factor of metabolic health. Although dietary interventions with probiotics, prebiotics, and synbiotics can be effective means to regulate obesity and associated comorbidities, the underlying shifts in gut microbial communities, especially at the functional level, have not been characterized in great details. In this study, we sought […]

  • The gut microbiome is required for full protection against acute arsenic toxicity in mouse models


    ABSTRACT Arsenic poisons an estimated 200 million people worldwide through contaminated food and drinking water. Confusingly, the gut microbiome has been suggested to both mitigate and exacerbate arsenic toxicity. Here, we show that the microbiome protects mice from arsenic-induced mortality. Both antibiotic-treated and germ-free mice excrete less arsenic in stool and accumulate more arsenic in […]

  • Commensal Microbiota Promote Lung Cancer Development via γδ T Cells


    SUMMARY Lung cancer is closely associated with chronic inflammation, but the causes of inflammation and the specific immune mediators have not been fully elucidated. The lung is a mucosal tissue colonized by a diverse bacterial community, and pulmonary infections commonly present in lung cancer patients are linked to clinical outcomes. Here, we provide evidence that […]

  • Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones


    ABSTRACT Central estrogen signaling coordinates energy expenditure, reproduction, and in concert with peripheral estrogen impacts skeletal homeostasis in females. Here, we ablate estrogen receptor alpha (ERα) in the medial basal hypothalamus and find a robust bone phenotype only in female mice that results in exceptionally strong trabecular and cortical bones, whose density surpasses other reported […]

  • A defined commensal consortium elicits CD8 T cells and anti-cancer immunity


    ABSTRACT There is a growing appreciation for the importance of the gut microbiota as a therapeutic target in various diseases. However, there are only a handful of known commensal strains that can potentially be used to manipulate host physiological functions. Here we isolate a consortium of 11 bacterial strains from healthy human donor faeces that […]

  • The Metabolic Response to a Low Amino Acid Diet is Independent of Diet-Induced Shifts in the Composition of the Gut Microbiome


    ABSTRACT Obesity and type 2 diabetes are increasing in prevalence around the world, and there is a clear need for new and effective strategies to promote metabolic health. A low protein (LP) diet improves metabolic health in both rodents and humans, but the mechanisms that underlie this effect remain unknown. The gut microbiome has recently […]

  • Asperlin Stimulates Energy Expenditure and Modulates Gut Microbiota in HFD-Fed Mice


    ABSTRACT Asperlin is a marine-derived, natural product with antifungal, anti-inflammatory and anti-atherosclerotic activities. In the present study, we showed that asperlin effectively prevented the development of obesity in high-fat diet (HFD)-fed mice. Oral administration of asperlin for 12 weeks significantly suppressed HFD-induced body weight gain and fat deposition without inhibiting food intake. Hyperlipidemia and liver […]

  • Events
    We maintain a calendar of events and meetings related to the field of Microbiome Research. Check it often for new events and conferences, or submit something for the calendar here.

  • Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice


    Significance Studies using experimental models have indicated that multiple sclerosis (MS)-like disease can be triggered in the gut following interactions of brain autoimmune T lymphocytes with local microbiota.

  • BOOK REVIEW: GNOTOBIOTICS


    Gnotobiotics, edited by Trenton Schoeb and Kathryn Eaton, is invaluable to those developing or managing gnotobiotic facilities.

  • Stress could be just as unhealthy as junk food


    Brigham Young University: We all know that a poor diet is unhealthy, but a new BYU study finds that stress may just as harmful to our bodies as a really bad diet.

  • Infection via mosquito bite alters Zika virus replication kinetics in rhesus macaques


    Abstract For more than three decades it has been recognized that small amounts of vector saliva can significantly alter the infectivity of vector-borne pathogens and subsequent in vivo dynamics.

  • Of Mice, Dirty Mice, and Men: Using Mice To Understand Human Immunology


    Abstract Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans.

  • Microbial Genetic Composition Tunes Host Longevity


    Highlights •Systematic analysis of longevity-promoting microbial genetic variations •Colanic acid as a pro-longevity natural compound effective in different species

  • Learning more about the gut microbiota


    The GMFH editing team recommends these book selections on the topic.

  • Stay up-to-date!
    Email Address *
    First Name
    Last Name

    * indicates required
    Privacy Policy




    Terms & Conditions | Privacy Policy | © 2019 The Translational Microbiome Research Forum