The Translational Microbiome Research Forum is an online resource for scientists engaged in translational microbiome research to access current, topical information and to provide a platform to exchange knowledge and ideas. We encourage you to participate by actively using the commenting system, by submitting links, resources, and your original research, and by joining our email list to receive updates when new content is posted.

  • Examining the role of the microbiome in the effectiveness of colorectal cancer treatment
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    UMass Medical School researchers find connection between bacteria and chemotherapy drugs in lab study

  • Infant mice lack microbes that help fight intestinal infection
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    A new study in mice suggests that newborns are more susceptible to intestinal infection because they harbor undeveloped gut microbiomes, and also hints at a way to boost colonization of healthy microbes that protect from pathogens.

  • Inflammation, gut microbiota, and obesity: What’s the link?
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    Fast food, gut microbes, sweet drinks, desk jobs: over the years, obesity has been blamed on many things.

  • Bad mix of gut microbes triggers age-associated inflammation
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    Inflammation increases with age and this leads to ill-health problems. One of the triggers appears to be the balance of microorganisms in the gut. This is based on studies using mice and the findings may well apply to people.

  • ‘Genetic scalpel’ can manipulate the microbiome, Yale study shows
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    The gut microbiome is crucial to health, encompassing bacterial communities that possess a hundred times more genes than the human genome.

  • Giardiasis may be a disease of the ecology of the GI tract
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    Colonization by the human and animal parasite, Giardia, changed the species composition of the mouse microbiome in a way that might be harmful. The research is published in Infection and Immunity, a journal of the American Society for Microbiology.

  • ‘Genetic scalpel’ can manipulate the microbiome, study shows
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    The gut microbiome is crucial to health, encompassing bacterial communities that possess a hundred times more genes than the human genome.

  • Virus may lead to celiac disease through disruption of intestinal immune homeostasis
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    Celiac disease (CeD) is a complex immune mediated disorder that is triggered by abnormal immune responses to the dietary protein gluten, which is found in grains like wheat, barley, and rye.

  • This lab-made probiotic fights off infections from unfriendly bacteria
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    As scientists continue their exploration of the thousands of organisms that live inside our body, a new study is showing just how much one “good” bacteria can be exploited to its host’s advantage.

  • Bacterial Metabolism Affects the C. elegans Response to Cancer Chemotherapeutics
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    Highlights •Bacteria differentially affect the C. elegans response to FUDR and camptothecin •Bacterial metabolism is required for the C. elegans chemotherapeutic response •Genetic screens with two bacterial species and three drugs to unravel mechanism

  • Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction.
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    Abstract Levels of inflammatory mediators in circulation are known to increase with age, but the underlying cause of this age-associated inflammation is debated.

  • Giardia alters commensal microbial diversity throughout the murine gut
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    ABSTRACT Giardia lamblia is the most frequently identified protozoan cause of intestinal infection.

  • Bacteria isolated from lung modulate asthma susceptibility in mice
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    Abstract Asthma is a chronic, non-curable, multifactorial disease with increasing incidence in industrial countries.

  • Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens
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    Abstract The high susceptibility of neonates to infections has been assumed to be due to immaturity of the immune system, but the mechanism remains unclear.

  • Engineered Regulatory Systems Modulate Gene Expression of Human Commensals in the Gut
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    Highlights •We introduce tools for modulating microbiome gene expression inside the gut •Engineered promoters couple gene expression in Bacteroides to a synthetic inducer

  • Urinary and Fecal Metabonomics Study of the Protective Effect of Chaihu-Shu-Gan-San on Antibiotic-Induced Gut Microbiota Dysbiosis in Rats
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    Abstract Accumulating evidence suggests that the gut microbiota dysbiosis and their host metabolic phenotype alteration is an important factor in human disease development.

  • Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease
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    Viruses compound dietary pathology Reoviruses commonly infect humans and mice asymptomatically. Bouziat et al. found that immune responses to two gut-infecting reoviruses take different paths in mice (see the Perspective by Verdu and Caminero).

  • Intestinal, extra-intestinal and systemic sequelae of Toxoplasma gondii induced acute ileitis in mice harboring a human gut microbiota
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    Abstract Background Within seven days following peroral high dose infection with Toxoplasma gondii susceptible conventionally colonized mice develop acute ileitis due to an underlying T helper cell (Th) -1 type immunopathology.

  • Mammary microbiota of dairy ruminants: fact or fiction?
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    Pascal Rainard (Veterinary Research/Opinion): Explorations of how the complex microbial communities that inhabit different body sites might contribute to health and disease have prompted research on the ways the harmonious relationship between a host and its microbiota could be used to keep animals healthy in their production conditions.

  • Microbe and the Mind: Speaker Sees Promise in Exploring the Brain-Gut Connections
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    Alison Sampson: The UC Gardner Neuroscience Institute presented its first Neuroscience Day as part of Research Week 2017. One of the day’s events included neuroscience guest speaker John F. Cryan, PhD, professor and chair, Department of Anatomy and Neuroscience, University College Cork, Ireland.

  • Events
    We maintain a calendar of events and meetings related to the field of Microbiome Research. Check it often for new events and conferences, or submit something for the calendar here.

  • To see the unseen: ‘Microbiomes’ show explores the common ground between arts, science
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    At first glance, it may appear that scientists and artists look at the world in different ways, but look again: Careful observation is at the heart of both callings. “Microbiomes: To See the Unseen,” the latest collaboration between the arts and sciences at The Arts Center in Corvallis, takes that observation to a microscopic level:

  • Bill Gates and Ed Yong Talk About Microbes
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    Of Microbes and Men You Should Appreciate Germs By Bill Gates Find Out More: gatesnotes

  • Sampling Strategies for Three-Dimensional Spatial Community Structures in IBD Microbiota Research
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    Identifying intestinal microbiota is arguably an important task that is performed to determine the pathogenesis of inflammatory bowel diseases (IBD); thus, it is crucial to collect and analyze intestinally-associated microbiota.

  • VIDEO: The World Of Microbes With Dr. B. Brett Finlay
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    In this brief video, Dr. B. Brett Finlay describes the fascinating world of microbes, and tells the story of his discovery of the E-Coli 0157 vaccine:

  • VIDEO: What If You Had A Second Brain?
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    AsapScience, stylized as AsapSCIENCE, is a YouTube channel created by Canadian youtubers Mitchell Moffit and Gregory Brown. The channel produces weekly videos that touch on many different topics of science. Check Out Here: AsapSCIENCE

  • Home-Made Cost Effective Preservation Buffer Is a Better Alternative to Commercial Preservation Methods for Microbiome Research
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    The investigation of wildlife gastrointestinal microbiomes by next-generation sequencing approaches is a growing field in microbial ecology and conservation.

  • Free Webinar: Precision Medicine – Learning Lessons From the Microbiome
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    Summary The influence of gut microbiota on human health has been well documented, particularly in the case of metabolic disorders, such as type 1 and type 2 diabetes.

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