The Translational Microbiome Research Forum is an online resource for scientists engaged in translational microbiome research to access current, topical information and to provide a platform to exchange knowledge and ideas. We encourage you to participate by actively using the commenting system, by submitting links, resources, and your original research, and by joining our email list to receive updates when new content is posted.

  • TH17-INDUCING GUT BACTERIA CAN PROMOTE AUTISM-LIKE BEHAVIOR IN MOUSE PUPS
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    On September 13, 2017 researchers from the Massachusetts Institute of Technology and the University of Massachusetts Medical School simultaneously published papers in Nature on the same intriguing topic: a link between autism and infection during pregnancy.

  • Gut bacteria could determine whether you develop PTSD
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    Molecular Biologists found that you’re more likely to develop PTSD if you lack in certain immune supporting bacteria

  • Gut microbes could help trigger multiple sclerosis
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    The trillions of bacteria that live in our intestines, known collectively as the gut microbiome, have been linked to maladies from eye disease to rheumatoid arthritis. Now, two new studies have added another disease: multiple sclerosis (MS)

  • The Next Big Performance Enhancing Drug: Bacteria From Elite Athletes’ Guts?
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    When Jonathan Scheiman describes his lab as “a lot of crazy shit,” he’s not kidding. For the last three years, the 35-year-old molecular biologist has been working at Harvard University studying the, um, stool of pro marathoners, ultra- runners, and Olympic rowers.

  • Two new studies support the link between the gut microbiome and multiple sclerosis
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    Previous research has found that multiple sclerosis (MS) patients may have a specific microbial signature in their gut microbiota that could impact disease pathogenesis.

  • Global Human Microbiome Market Size and Forecast to 2021
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    Description: Human Microbiome Report by Material, Application, and Geography — Global Forecast to 2021 is a professional and comprehensive research report on the world’s major regional market conditions, focusing on the main regions (North America, Europe and Asia-Pacific) and the main countries (United States, Germany, United Kingdom,Japan, South Korea and China).

  • Enterome’s EB8018, a First-in-class Drug Candidate Targeting Crohn’s Disease, Successfully Completes Phase I Study in Healthy Volunteers
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    ENTEROME SA, a pioneer of innovative therapies for microbiome-related diseases, is pleased to announce the successful completion of the first Phase 1 clinical study with its lead candidate EB8018, a small molecule designed to block FimH, as a potential new orally-administered treatment for Crohn’s disease.

  • Scientists investigate the ‘black box’ of bacterial effects on the brain and behaviour
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    Researchers from McMaster University (Canada) had a clear question in mind when they conducted their recent experiment: if a mouse had its gut microbiota altered by antibiotics in early life, what would happen to its brain?

  • How gut bacteria saved ‘dirty mice’ from death
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    Even if you’re a clean freak, it’s hard to escape a decade of discoveries that some of the microbes naturally residing in your body—your microbiome—help keep you healthy.

  • Brown rice and retrograded brown rice alleviate inflammatory response in dextran sulfate sodium (DSS)-induced colitis mice

    ABSTRACT The present study was aimed to investigate the impacts of brown rice (BR) and retrograded brown rice (R-BR) consumption on colonic health and gut microbiota in dextran sulfate sodium (DSS) induced colitis mice. Thirty two female C57Bl/6Mlac mice were fed with modified AIN 93G diets by replacing cornstarch in the original composition with white […]

  • Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models

    ABSTRACT We have experimentally investigated the immunoregulatory effects of human gut microbiota in multiple sclerosis (MS). We have identified specific bacteria that are associated with MS and demonstrated that these bacteria regulate T lymphocyte-mediated adaptive immune responses and contribute to the proinflammatory environment in vitro and in vivo. Thus, our results expand the knowledge of […]

  • Multi-omics Comparative Analysis Reveals Multiple Layers of Host Signaling Pathway Regulation by the Gut Microbiota
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    ABSTRACT The bodies of mammals are hosts to vast microbial communities composed of trillions of bacteria from thousands of species, whose effects on health and development have begun to be appreciated only recently.

  • Supplementation of pancreatic digestive enzymes alters the composition of intestinal microbiota in mice
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    Highlights •Oral supplementation of pancrelipase alters composition of intestinal microbiota. •Over-represented taxa include bacteria promoting intestinal homeostasis.

  • Ethanol extract of Atractylodis macrocephalae Rhizoma ameliorates insulin resistance and gut microbiota in type 2 diabetic db/db mice
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    Highlights •This is the first study on the anti-diabetic effect of AMK in db/db mice. •AMK attenuated insulin resistance and regulated glucose and lipid metabolism.

  • Study on alterations of physiological functions in aged constipation rats with fluid-deficiency based on metabonomic and microbiology analysis
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    Abstract Constipation, a common and complex clinical symptom, is a predisposing factor for many serious diseases, such as gastrointestinal diseases, cardiovascular diseases and cancers.

  • Clinical Effect of IRT-5 Probiotics on Immune Modulation of Autoimmunity or Alloimmunity in the Eye
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    Abstract: Background: Although the relation of the gut microbiota to a development of autoimmune and inflammatory diseases has been investigated in various animal models, there are limited studies that evaluate the effect of probiotics in the autoimmune eye disease.

  • Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation
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    Gut reasons to brush your teeth Some gut conditions, such as inflammatory bowel disease (IBD), ulcerative colitis, and Crohn’s disease (CD), are associated with imbalances in the gut microbe community.

  • The microbiome and the hallmarks of cancer
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    Introduction The “Hallmarks of Cancer,” proposed by Hanahan and Weinburg in 2001 and updated in 2011, logically define how a normal cell progresses to a tumorigenic state within a complex neoplastic environment [1].

  • Microbiome Drug Development Event

    Despite increased investment, there are still major challenges generating effective pre-clinical data and translating that into the clinic; including building an effective CMC strategy that allows a realistic scale-up. Another major challenge is navigating the regulatory landscape in Europe which is becoming increasingly difficult and has even resulted in companies setting up offices in the […]

  • Uncovering the function of host-associated microbial communities
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    This post is by MSU grad student Connie Rojas: Microbes colonize every surface of their hosts. Once established, they do not live in isolated patches, but instead form highly regulated, structurally and functionally organized communities, termed ‘microbiota’.

  • Events
    We maintain a calendar of events and meetings related to the field of Microbiome Research. Check it often for new events and conferences, or submit something for the calendar here.

  • Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice
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    Significance Studies using experimental models have indicated that multiple sclerosis (MS)-like disease can be triggered in the gut following interactions of brain autoimmune T lymphocytes with local microbiota.

  • BOOK REVIEW: GNOTOBIOTICS
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    Gnotobiotics, edited by Trenton Schoeb and Kathryn Eaton, is invaluable to those developing or managing gnotobiotic facilities.

  • Stress could be just as unhealthy as junk food
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    Brigham Young University: We all know that a poor diet is unhealthy, but a new BYU study finds that stress may just as harmful to our bodies as a really bad diet.

  • Infection via mosquito bite alters Zika virus replication kinetics in rhesus macaques
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    Abstract For more than three decades it has been recognized that small amounts of vector saliva can significantly alter the infectivity of vector-borne pathogens and subsequent in vivo dynamics.

  • Of Mice, Dirty Mice, and Men: Using Mice To Understand Human Immunology
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    Abstract Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans.

  • Microbial Genetic Composition Tunes Host Longevity
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    Highlights •Systematic analysis of longevity-promoting microbial genetic variations •Colanic acid as a pro-longevity natural compound effective in different species

  • Learning more about the gut microbiota
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    The GMFH editing team recommends these book selections on the topic.

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