The Translational Microbiome Research Forum is an online resource for scientists engaged in translational microbiome research to access current, topical information and to provide a platform to exchange knowledge and ideas. We encourage you to participate by actively using the commenting system, by submitting links, resources, and your original research, and by joining our email list to receive updates when new content is posted.

  • Researchers Connect Brain Blood Vessel Lesions to Intestinal Bacteria
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    A study in mice and humans suggests that bacteria in the gut can influence the structure of the brain’s blood vessels, and may be responsible for producing malformations that can lead to stroke or epilepsy.

  • Cork scientists link gut bacteria to anxiety disorders
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    Scientists in Cork have given a new meaning to gut reaction. They have discovered that the microbiome, the collective trillions of bacteria within the gastrointestinal tract, regulates fear responses.

  • Penn study finds relationship between common brain disease and gut microbiome
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    Bacteria in the gut microbiome drive the formation of cerebral cavernous malformations (CCMs), clusters of dilated, thin-walled blood vessels in the brain that can cause stroke and seizures, according to new research published this week in Nature by researchers from the Perelman School of Medicine at the University of Pennsylvania.

  • GEN News Highlights: Circadian Rhythm Alters Gut Microbiome’s Response to Diet
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    The body’s internal biological clock is typically set in response to external cues, such as sunlight and temperature. Changes in this temporal schedule can affect a vast array of physiological systems, leading to the manifestation of observable physical changes.

  • Glucocorticoids as a double-edge sword in the inflamed intestine
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    Chronic intestinal inflammation, in the form of the conditions ulcerative colitis and Crohn’s disease, is relatively common.

  • Postbiotics May Prevent Diabetes in Obesity
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    You’ve likely heard about probiotics—live bacteria with long, colorful names found in your yogurt that help generate a happy gut.

  • Research in people with IBS shows link between gut microbiota and brain regions
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    A new study by researchers at UCLA has revealed two key findings for people with irritable bowel syndrome about the relationship between the microorganisms that live in the gut and the brain.

  • How The Gut May Influence Food Choices: Fruit Flies With More Bacteria Had Fewer Cravings
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    Your stomach, rather than brain, may have more control over what you eat than you think. According to new research, gut bacteria communicate with the brain and influence some decisions.

  • Bugs for thought: Gut bacteria tell the brain what animals should eat
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    Could the bacteria that inhabit our gut influence our food choices? A new study shows, for the first time, that this idea may not be as far-fetched as it seems.

  • Diabetes-associated microbiota in fa/fa rats is modified by Roux-en-Y gastric bypass
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    Abstract Roux-en-Y gastric bypass (RYGB) and duodenal jejunal bypass (DJB), two different forms of bariatric surgery, are associated with improved glucose tolerance, but it is not clear whether the gut microbiota contributes to this effect.

  • Deleterious Metabolic Effects of High Fructose Intake: The Preventive Effect of Lactobacillus kefiri Administration

    Abstract Modern lifestyle and diets have been associated with metabolic disorders and an imbalance in the normal gut microbiota.

  • MyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium
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    Abstract MyD88-mediated signaling downstream of Toll-like receptors and the IL-1 receptor family is critically involved in the induction of protective host responses upon infections.

  • Impacts of Gut Bacteria on Human Health and Diseases
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    Abstract Gut bacteria are an important component of the microbiota ecosystem in the human gut, which is colonized by 1014 microbes, ten times more than the human cells.

  • Examining the efficacy of intravenous administration of predatory bacteria in rats
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    Abstract The proteobacteria Bdellovibrio bacteriovorus and Micavibrio aeruginosavorus are obligate predators of Gram-negative bacteria, and have been proposed to be used to treat multidrug-resistant bacterial infections.

  • The microbiome regulates amygdala-dependent fear recall
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    Abstract The amygdala is a key brain region that is critically involved in the processing and expression of anxiety and fear-related signals. In parallel, a growing number of preclinical and human studies have implicated the microbiome–gut–brain in regulating anxiety and stress-related responses.

  • Bifidobacterium pseudocatenulatum CECT 7765 supplementation restores altered vascular function in an experimental model of obese mice
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    Aims. Bifidobacterium pseudocatenulatum CECT 7765 improves metabolic and immunological altered functions in high fat fed mice, however little is known about the effects of potential probiotics on vascular reactivity.

  • Bifidobacterium CECT 7765 modulates early stress-induced immune, neuroendocrine and behavioral alterations in mice
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    Highlights • Early exposure to chronic psychological stress causes transient changes in the intestinal microbiota and the intestinal cytokine and neurotransmitter network with persistent effects on brain biochemistry and beheviour (anxiety), suggesting a role of the cross-talk between the gut-microbiota and the immune and nervous systems in early life.

  • Endothelial TLR4 and the microbiome drive cerebral cavernous malformations
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    Cerebral cavernous malformations (CCMs) are a cause of stroke and seizure for which no effective medical therapies yet exist.

  • Creative Minds: The Human Gut Microbiome’s Top 100 Hits
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    Posted on May 18, 2017 by Dr. Francis Collins: Microbes that live in dirt often engage in their own deadly turf wars, producing a toxic mix of chemical compounds (also called “small molecules”) that can be a source of new antibiotics.

  • Microbiome Startup BiomX Raises $24 Million in Series A Round
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    CHICAGO (GenomeWeb) – BiomX, a startup focused on microbiome therapeutics via a proprietary microbiome modulation technology platform, said today that it has raised $24 million in Series A venture capital.

  • Events
    We maintain a calendar of events and meetings related to the field of Microbiome Research. Check it often for new events and conferences, or submit something for the calendar here.

  • SteadyCom: Predicting microbial abundances while ensuring community stability
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    Abstract Genome-scale metabolic modeling has become widespread for analyzing microbial metabolism. Extending this established paradigm to more complex microbial communities is emerging as a promising way to unravel the interactions and biochemical repertoire of these omnipresent systems.

  • Optical nanofiber ‘hears’ bacteria swim, cancer cells move
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    At the macroscopic level that’s familiar to us, birds chirp, whales sing and we talk. But at the microscopic level, our cells pulsate, bacteria swim and pressure waves ripple on a scale we can’t reach.

  • Dirt Is Good: The Advantage of Germs for Your Child’s Developing Immune System
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    by Jack Gilbert (Author), Rob Knight (Author) From two of the world’s top scientists

  • THE REAL IMPACT OF RODENT DIET ON MICROBIOME AND GUT HEALTH RESEARCH WEBINAR Q&A
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    Dr. Michael Pellizzon of Research Diets, Inc., recently presented a webinar on the underappreciated impact of rodent diets on microbiome and gut health research, where simple husbandry decisions can profoundly affect both animal model phenotypes and experimental outcomes.

  • Evolving as a holobiont
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    Some of the most exciting recent advances in biology have been in our understanding of how the microbiome—the community of bacteria, fungi, and other single-celled microorganisms—influences host functions and behaviors.

  • Modern Tools and Techniques to Understand Microbes
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    Foreword Microbiology is one of the leading branches of modern biology and is interdisciplinary in scope as it interfaces with various basic and applied disciplines of science,

  • The Language of Microbial Culture: Explaining Prebiotics, Probiotics, Synbiotics and Postbiotics
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    It’s no secret that it’s one of my favorite subjects—the burgeoning field of human gastrointestinal microbiology. I know…it’s easy to get caught up in the comparative excitement of it all.

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