The Translational Microbiome Research Forum is an online resource for scientists engaged in translational microbiome research to access current, topical information and to provide a platform to exchange knowledge and ideas. We encourage you to participate by actively using the commenting system, by submitting events, and by joining our email list to receive updates when new content is posted.

  • On-Demand Webinar: Genetically Engineered Mouse Colitis Models for Preclinical Drug Development


    Genetically engineered mouse colitis models are increasing the flexibility and predictive validity of preclinical colitis models in inflammatory bowel disease (IBD) research. These powerful tools are increasingly supplementing or replacing traditional chemically induced models (e.g. DSS- or TNBS-induced colitis), and offer important translational and mechanistic insights in IBD drug development. View this webinar to learn […]

  • Update on the Upcoming “Virtual” Translational Microbiome Conference


    The 6th Annual Translational Microbiome Conference is carrying on as a “VIRTUAL” event this year on April 21st through the 24th. We’ve recently adjusted our agenda to accommodate a virtual event. Here are a few details regarding this event in case you’d like to join us: 4 days of learning via our virtual conference platform […]

  • Webinar Q&A — Microbiological Monitoring of Germ-Free and Gnotobiotic Colonies


    Dr. Paula Roesch recently presented a webinar on microbiological monitoring of germ-free and gnotobiotic colonies. Taconic Biosciences has decades of experience in this area and Dr. Roesch presented a thorough look at all aspects of the process, starting from tools and approaches to process validation and monitoring and moving into isolator monitoring techniques. She even […]

  • On-Demand Webinar: Microbiological Monitoring of Germ-free and Gnotobiotic Colonies


    In order to maintain germ-free colonies, researchers must implement specialized techniques and husbandry requirements not needed in standard vivariums. This is critical to prevent contamination within a gnotobiotic facility. Download this webinar to learn about appropriate validation of supply sterilization and recommended monitoring techniques for germ-free and gnotobiotic isolators. By watching you can learn: Autoclave, […]

  • Webinar Q&A — Controlling the Macroenvironment: A Novel Approach to Germ-free Derivations


    Dr. Cristina Weiner recently presented a webinar featuring a novel approach to germ-free derivations. She discussed the importance of understanding baseline performance and making incremental process improvements as well as how Taconic Biosciences developed and implemented a new facility design which supports improved germ-free derivation success. Q: You stated during the presentation that, on balance, […]

  • Time For Better Microbiome Research


    The microbiome needs no introduction – it has been several years since you could pick up a biomedical research journal and not run into an article on possible connections of human gut bacteria and disease. There were thousands of such papers last year alone. But it’s a very hard field to work in. You can […]

  • On-Demand Webinar: Controlling the Macroenvironment – A Novel Approach to Germ-free Derivations


    Download this webinar to learn a novel approach to germ-free derivations outside of the limitations of an isolator — an approach focused on control of the macroenvironment. Dr. Cristina Weiner, VMD, MS, DACLAM, presents and shares how applying cleanroom technology to gnotobiotic animal husbandry has resulted in the improved success of germ-free derivations. By watching […]

  • 2020 Microbiome Conferences


    Are you looking for a microbiome conference or workshop? Many 2020 conferences are outlined on our event’s page with differing agendas and meetings in the U.S., Europe, and Asia, these educational summits provide an opportunity to network and meet your peers. Here are the first few microbiome conferences of this year: Rhode Island Microbiome Symposium […]

  • Webinar Q&A — Validated Il10 Knockout Models for IBD Research


    Dr. Philip Dubé recently presented a webinar on validated Il10 knockout mouse models for IBD research. He gave an overview of research in this area and presented new data on these models from studies done by Boehringer Ingelheim and Incyte. Due to time constraints, many of the questions submitted during the webinar went unanswered. This […]

  • Neonatal Exposure to Commensal-Bacteria-Derived Antigens Directs Polysaccharide-Specific B-1 B Cell Repertoire Development


    Summary B-1 B cells derive from a developmental program distinct from that of conventional B cells, through B cell receptor (BCR)-dependent positive selection of fetally derived precursors. Here, we used direct labeling of B cells reactive with the N-acetyl-D-glucosamine (GlcNAc)-containing Lancefield group A carbohydrate of Streptococcus pyogenes to study the effects of bacterial antigens on […]

  • Microbiota modulate sympathetic neurons via a gut–brain circuit


    Abstract Connections between the gut and brain monitor the intestinal tissue and its microbial and dietary content1, regulating both physiological intestinal functions such as nutrient absorption and motility2,3, and brain-wired feeding behaviour2. It is therefore plausible that circuits exist to detect gut microorganisms and relay this information to areas of the central nervous system that, […]

  • Developing standards for the microbiome field


    Abstract Background Effective standardisation of methodologies to analyse the microbiome is essential to the entire microbiome community. Despite the microbiome field being established for over a decade, there are no accredited or certified reference materials available to the wider community. In this study, we describe the development of the first reference reagents produced by the […]

  • A Humanized Diet Profile May Facilitate Colonization and Immune Stimulation in Human Microbiota-Colonized Mice


    Background: In spite of the importance of the use of gnotobiotic mice for human fecal transfer, colonization efficiency and immune stimulation after human microbiota inoculation in mice are poorly studied compared to mouse microbiota inoculation. We tested the colonization efficiency and immune responses in mice bred for one additional generation after inoculating the parent generation […]

  • C9orf72 suppresses systemic and neural inflammation induced by gut bacteria


    Abstract A hexanucleotide-repeat expansion in C9ORF72 is the most common genetic variant that contributes to amyotrophic lateral sclerosis and frontotemporal dementia1,2. The C9ORF72 mutation acts through gain- and loss-of-function mechanisms to induce pathways that are implicated in neural degeneration3,4,5,6,7,8,9. The expansion is transcribed into a long repetitive RNA, which negatively sequesters RNA-binding proteins5 before its […]

  • Genetic and metabolic links between the murine microbiome and memory


    Abstract Background Recent evidence has linked the gut microbiome to host behavior via the gut–brain axis [1,2,3]; however, the underlying mechanisms remain unexplored. Here, we determined the links between host genetics, the gut microbiome and memory using the genetically defined Collaborative Cross (CC) mouse cohort, complemented with microbiome and metabolomic analyses in conventional and germ-free […]

  • Gut Microbiota Modulate CD8 T Cell Responses to Influence Colitis-Associated Tumorigenesis


    Summary There is increasing evidence that gut microbiome perturbations, also known as dysbiosis, can influence colorectal cancer development. To understand the mechanisms by which the gut microbiome modulates cancer susceptibility, we examine two wild-type mouse colonies with distinct gut microbial communities that develop significantly different tumor numbers using a mouse model of inflammation-associated tumorigenesis. We […]

  • Gut-Resident Lactobacilli Activate Hepatic Nrf2 and Protect Against Oxidative Liver Injury


    Summary Many studies have suggested a role for gut-resident microbes (the “gut microbiome”) in modulating host health; however, the mechanisms by which they impact systemic physiology remain largely unknown. In this study, metabolomic and transcriptional profiling of germ-free and conventionalized mouse liver revealed an upregulation of the Nrf2 antioxidant and xenobiotic response in microbiome-replete animals. […]

  • Variations in microbiota composition of laboratory mice influence Citrobacter rodentium infection via variable short-chain fatty acid production


    Author summary The distinct composition of the gut microbiota in each individual results in variable metabolic activity and output of these communities, which influences the host, including resistance to enteric pathogens. Lack of reproducibility in biomedical research is nowadays frequently attributed to the microbiota, but little is known about which specific members and metabolites contribute […]

  • Events
    We maintain a calendar of events and meetings related to the field of Microbiome Research. Check it often for new events and conferences, or submit something for the calendar here.

  • Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice


    Significance Studies using experimental models have indicated that multiple sclerosis (MS)-like disease can be triggered in the gut following interactions of brain autoimmune T lymphocytes with local microbiota.

  • BOOK REVIEW: GNOTOBIOTICS


    Gnotobiotics, edited by Trenton Schoeb and Kathryn Eaton, is invaluable to those developing or managing gnotobiotic facilities.

  • Stress could be just as unhealthy as junk food


    Brigham Young University: We all know that a poor diet is unhealthy, but a new BYU study finds that stress may just as harmful to our bodies as a really bad diet.

  • Infection via mosquito bite alters Zika virus replication kinetics in rhesus macaques


    Abstract For more than three decades it has been recognized that small amounts of vector saliva can significantly alter the infectivity of vector-borne pathogens and subsequent in vivo dynamics.

  • Of Mice, Dirty Mice, and Men: Using Mice To Understand Human Immunology


    Abstract Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans.

  • Microbial Genetic Composition Tunes Host Longevity


    Highlights •Systematic analysis of longevity-promoting microbial genetic variations •Colanic acid as a pro-longevity natural compound effective in different species

  • Learning more about the gut microbiota


    The GMFH editing team recommends these book selections on the topic.

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