The Translational Microbiome Research Forum is an online resource for scientists engaged in translational microbiome research to access current, topical information and to provide a platform to exchange knowledge and ideas. We encourage you to participate by actively using the commenting system, by submitting links, resources, and your original research, and by joining our email list to receive updates when new content is posted.

  • Yale study shows that gut microbes could trigger type 1 diabetes
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    A new study led by Yale University reports that changes in the gut microbiome could be a factor in the development of type 1 diabetes.

  • One Antigen Receptor Induces Two T cell Types

    Precursor T cells bearing the same antigen receptor adopt two different fates in mice.

  • Antibiotic Therapy During Infancy Increases Type 1 Diabetes Risk in Mice
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    Three therapeutic doses administered during early life disturb the animals’ microbiomes and lead to enduring changes in the immune systems of non-obese diabetic mice, researchers report.

  • Researchers Target Gut Bacteria to Reduce Weight Gain

    Westminster, Colo. (August 26, 2016)—A new therapy that involves engineered gut bacteria may one day help reduce the health problems that come with obesity.

  • Breeding a New Generation of Germ-Free Lab Mice
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    Normal rodents sell for $30 a pop. Taconic’s new breed goes for over $480 apiece, and could be instrumental in microbiome research.

  • Does The Microbiome Affect Behavior in Germ-Free Mice?
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    There is growing evidence that the microbiome, that collection of all the microorganisms which inhabit an individual, can affect cognition and behavior.

  • Gut reaction: the surprising power of microbes

    ‘So, what’s in the thermos?” I asked. I was standing in a lift at Washington University in St Louis, with Professor Jeff Gordon and two of his students, one of whom was holding a metal canister.

  • Are You Your Microbiome? Ed Yong Explains It All
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    Writer Ed Yong has been chronicling the science of microbial life for years at such outlets as The New York Times, the Atlantic (where he is now a staff writer) and his blog, Not Exactly Rocket Science (currently hosted by National Geographic).

  • Mouse microbes may make scientific studies harder to replicate
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    In the first experiment, Laura McCabe’s lab seemed to hit a home run. The physiologist and her team at Michigan State University (MSU) in East Lansing were testing how a certain drug affects bone density, and they found that treated lab mice lost bone compared with controls.

  • GUT CHECK: THE MICROBIOME GAME
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    Gut Check is a scientific, strategic and competitive board game designed to be enjoyable for scientists, students and game enthusiasts alike. The game consists of several card types, including beneficial, opportunistic and pathogenic microbes, infections and events.

  • Metabolomics – A Key Technology for Microbiome Research
    Metabolic Process Microbiome


    Bacteria have co-evolved with us for thousands of years. We now understand that they are closely linked to many aspects of health. But, in most cases, the complex influences of microbiota on our health is not yet functionally understood.

  • FAQ on Microbiology of Built Environments from the American Academy of Microbiology
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    There is a report out from the American Academy of Microbiology that is based on the “Microbiology of the Built Environment” colloquium they hosted in September 2015.

  • The Hidden World of Microbiomes
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    What are microbiomes and how many do you have in your body? Read the comic or watch the video here: PHD Comics.

  • Micro Size, Macro Opportunity: Looking for New Applications of our Microbiome
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    The “microbiome” is a bustling city of diverse and dynamic bacteria, and its potential for helping patients has scientists and researchers excited for the future.

  • Working with Germ-Free Mice
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    The volume of published studies employing axenic or germ-free mice increased dramatically over the past 15 years, in part due to growing interest in microbiome research.

  • Episode 05: Micro But Mighty
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    Let’s start with a definition: what is the microbiome? Simply put, the microbiome is the collection of microbes (mostly bacteria) that live in and on your body.

  • How to Culture Uncultured Organisms
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    Many microorganisms are “unculturable,” or at least not able to grow in known media. Now, a new tool enables researchers to predict what nutrients organisms need to thrive in the lab, eliminating most of the guesswork involved in setting up new cultures.

  • The Mycobiome
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    At a workshop held at the National Institutes of Health  (NIH) last September on the role of human microbiota in infectious disease, I was disheartened not to hear a single talk on the fungal community—the mycobiome.

  • Advancing Microbiome Research Symposium: Microbiome & Disease

    Call for presenters and posters at Taconic’s Advancing Microbiome Research Symposium: Microbiome & Disease. Event is November 17th in Chicago, IL. Submission deadline is September 19th. Get more details here: Register Now!

  • WEBINAR: Intro to the Microbiome

    Interest in the microbiome and its role in health and disease is a rapidly growing research focus for academic institutions, biotech and pharmaceutical companies.

  • Events
    We maintain a calendar of events and meetings related to the field of Microbiome Research. Check it often for new events and conferences, or submit something for the calendar here.

  • Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8+ T Cell-Mediated Immunity in Colorectal Cancer
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    Abstract Although all-trans-retinoic acid (atRA) is a key regulator of intestinal immunity, its role in colorectal cancer (CRC) is unknown. We found that mice with colitis-associated CRC had a marked deficiency in colonic atRA due to alterations in atRA metabolism mediated by microbiota-induced intestinal inflammation. Human ulcerative colitis (UC), UC-associated CRC, and sporadic CRC specimens […]

  • Interleukin-15 promotes intestinal dysbiosis with butyrate deficiency associated with increased susceptibility to colitis

    Abstract Dysbiosis resulting in gut-microbiome alterations with reduced butyrate production are thought to disrupt intestinal immune homeostasis and promote complex immune disorders. However, whether and how dysbiosis develops before the onset of overt pathology remains poorly defined.

  • Structural modulation of the gut microbiota and the relationship with body weight: compared evaluation of liraglutide and saxagliptin treatment

    Abstract The mechanisms underlying the weight-loss effect of GLP-1 receptor agonists need further elucidation. The present study was performed to explore the effects of liraglutide and saxagliptin on the composition of the gut microbiota.

  • Sex-specific effects of docosahexaenoic acid (DHA) on the microbiome and behavior of socially-isolated mice

    Abstract Dietary supplementation with the long-chain omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) has been shown to have a beneficial effect on reducing the symptoms associated with several neuropsychiatric conditions including anxiety and depression.

  • Effects of different diets on intestinal microbiota and nonalcoholic fatty liver disease development

    Abstract Aim To study the effects of different diets on intestinal microbiota and nonalcoholic fatty liver disease (NAFLD) development at the same caloric intake.

  • Functional characteristics of the gut microbiome in C57BL/6 mice differentially susceptible to Plasmodium yoelii

    Abstract C57BL/6 mice are widely used for in vivo studies of immune function and metabolism in mammals.

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