The Translational Microbiome Research Forum is an online resource for scientists engaged in translational microbiome research to access current, topical information and to provide a platform to exchange knowledge and ideas. We encourage you to participate by actively using the commenting system, by submitting links, resources, and your original research, and by joining our email list to receive updates when new content is posted.

  • How Miraculous Microbes Help Us Evolve Better, Faster, Stronger

    Invisible yet crucial, our microbial partners add a gene-swapping plot twist to evolutionary theory.

  • Antibiotics weaken Alzheimer’s disease progression through changes in the gut microbiome

    Long-term antibiotic treatment in mice decreases levels of disease-causing plaques and enhances neuroinflammatory activity of microglial cells.

  • New study suggests potential role for gut microbiota in diabetes remission after bypass surgery

    Studies have shown that bariatric surgery can lead to remission of type 2 diabetes mellitus (T2DM) in rodents and humans, but this beneficial effect cannot be explained solely by weight loss.

  • Gut bacteria can cause, predict and prevent rheumatoid arthritis

    The bacteria in your gut do more than break down your food.

  • Tiny bacteria-powered ‘windfarm’ for your phone?

    A team of scientists from Oxford University has shown how the natural movement of bacteria could be harnessed to assemble and power microscopic ‘windfarms’ — or other human-made micromachines such as smartphone components.

  • Good gut relationships key in defence against pathogens

    Fighting infection in the gut relies on a dynamic relationship between the cells that line gut walls and microbiota – the hundreds of different bacteria that co-exist within the human body without causing harm.

  • Farewell to Animal Testing: Innovations on Human Intestinal Microphysiological Systems

    Abstract The human intestine is a dynamic organ where the complex host-microbe interactions that orchestrate intestinal homeostasis occur.

  • Novel suite of computer algorithms can accurately predict behavior of gut microbiome

    A team of investigators from Brigham and Women’s Hospital and the University of Massachusetts have developed a suite of computer algorithms that can accurately predict the behavior of the microbiome – the vast collection of microbes living on and inside the human body.

  • Global Microbiome Initiative Explores Subways for Drug-Resistance Markers

    Weill Cornell Medicine researchers will use tools and technologies from Qiagen and CosmosID in a global study that the partners said today will collect DNA and RNA samples from high-traffic areas in subway systems, buses, and parks in 54 cities worldwide, the companies said today.

  • Metabolomics – A Key Technology for Microbiome Research
    Metabolic Process Microbiome

    Bacteria have co-evolved with us for thousands of years. We now understand that they are closely linked to many aspects of health. But, in most cases, the complex influences of microbiota on our health is not yet functionally understood.

  • FAQ on Microbiology of Built Environments from the American Academy of Microbiology

    There is a report out from the American Academy of Microbiology that is based on the “Microbiology of the Built Environment” colloquium they hosted in September 2015.

  • The Hidden World of Microbiomes

    What are microbiomes and how many do you have in your body? Read the comic or watch the video here: PHD Comics.

  • Micro Size, Macro Opportunity: Looking for New Applications of our Microbiome

    The “microbiome” is a bustling city of diverse and dynamic bacteria, and its potential for helping patients has scientists and researchers excited for the future.

  • Working with Germ-Free Mice

    The volume of published studies employing axenic or germ-free mice increased dramatically over the past 15 years, in part due to growing interest in microbiome research.

  • Episode 05: Micro But Mighty

    Let’s start with a definition: what is the microbiome? Simply put, the microbiome is the collection of microbes (mostly bacteria) that live in and on your body.

  • How to Culture Uncultured Organisms

    Many microorganisms are “unculturable,” or at least not able to grow in known media. Now, a new tool enables researchers to predict what nutrients organisms need to thrive in the lab, eliminating most of the guesswork involved in setting up new cultures.

  • The Mycobiome

    At a workshop held at the National Institutes of Health  (NIH) last September on the role of human microbiota in infectious disease, I was disheartened not to hear a single talk on the fungal community—the mycobiome.

  • WEBINAR: Exercise as a Lens to View the Microbiome and Intestinal Health

    Join us for a webinar on August 4, 2016 exploring the complex relationship between diet, exercise and the microbiome.

  • WEBINAR: Inflammatory Bowel Disease in Humanized Mice

    Join us for a webinar on July 26, 2016 introducing the use of the human Inflammatory Bowel Disease (IBD) in the NOG mouse for better preclinical drug candidate profiling.

  • Events
    We maintain a calendar of events and meetings related to the field of Microbiome Research. Check it often for new events and conferences, or submit something for the calendar here.

  • Analysis of the mouse gut microbiome using full-length 16S rRNA amplicon sequencing.

    Abstract Demands for faster and more accurate methods to analyze microbial communities from natural and clinical samples have been increasing in the medical and healthcare industry.

  • Gastric Bypass Surgery Reverses Diabetic Phenotypes in Bdnf-Deficient Mice

    Abstract Duodenum-jejunum gastric bypass (DJB) has been used to treat morbid diabetic patients. However, neither the suitability among patients nor the mechanisms of this surgical treatment is clear.

  • High-fiber and high-protein diets shape different gut microbial communities, which ecologically behave similarly under stress conditions, as shown in a gastrointestinal simulator

    Abstract The aim of this work was to investigate the relationship between the structure of gut microbial communities fed with different diets (i.e. high-protein – HP – vs. high-fiber – HF – diet) and their functional stability when challenged with mild and acute doses of a mix of amoxicillin, ciprofloxacin and tetracycline.

  • Dietary silver nanoparticles can disturb the gut microbiota in mice

    Abstract Background Humans are increasingly exposed via the diet to Ag nanoparticles (NP) used in the food industry. Because of their anti-bacterial activity, ingested Ag NP might disturb the gut microbiota that is essential for local and systemic homeostasis.

  • Modelling Longitudinal Metabonomics and Microbiota Interactions in C57BL/6 mice fed a high fat diet

    Abstract Longitudinal studies aim typically at following populations of subjects over time and are important to understand the global evolution of biological processes.

  • Human Gut-Derived Prevotella histicola Suppresses Inflammatory Arthritis in Humanized Mice

    Abstract Objective: The gut microbiome regulates host immune homeostasis. Rheumatoid arthritis (RA) is associated with intestinal dysbiosis. In this study we used a human gut-derived commensal to modulate immune response and treat arthritis in a humanized mouse model.

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