University of Alabama at Birmingham researchers have created a small molecule that prevents or impedes tooth cavities in a preclinical model. The inhibitor blocks the function of a key virulence enzyme in an oral bacterium, a molecular sabotage that is akin to throwing a monkey wrench into machinery to jam the gears. In the presence […]
Previous research has shown the aging process and frailty may be associated with a perturbed gut microbiome in elderly people.
Researchers have shown that a core bacterial community in the hindgut of horses shows some degree of stability over time when the animals are on a uniform diet.
What hasn’t the microbiome been linked to in mice? For years, the potential therapeutic value of our so-called “second genome” has been celebrated in successive press releases from researchers around the world.
Microbiome researchers Rob Knight, PhD, University of California San Diego, Jeffrey Gordon, MD, Washington University School of Medicine in St. Louis, and Norman Pace, PhD, University of Colorado Boulder, will share this year’s Massry Prize, splitting the $200,000 honorarium.
A common gut bacterium may break down compounds found in blueberries, black tea and other foods to boost interferon and help your immune system fight the influenza virus
The bacterium that causes Lyme disease, Borrelia burgdorferi, may have some help from a gene found in the guts of infected ticks, according to a new study led by Yale researchers and published in Nature Communications.
New research explores how the tiny organisms in your gut might be influencing your immune system and lupus disease activity
TORONTO, Aug. 1, 2017 /CNW/ – Crohn’s and Colitis Canada is pleased to announce its Grants-in-Aid and Innovations in Inflammatory Bowel Disease (IBD) Grant recipients.
Abstract Human health is intricately intertwined with the composition and function of the trillions of microorganisms that make up the gastrointestinal (GI) microbiome.
Abstract Streptococcus mutans employs a key virulence factor, three glucosyltransferase (GtfBCD) enzymes to establish cariogenic biofilms.
Abstract Background Age is an important risk factor for rheumatoid arthritis (RA), which often develops in middle age. However, how age-associated changes in immunity impact RA is poorly understood.
Highlights • A human gut bacterium has potential as a therapy for multiple sclerosis (MS) • P. histicola can suppress disease in a preclinical animal model of MS • P. histicola suppresses disease by inducing CD4+ FoxP3+ regulatory T cells
Abstract CX3CR1+ macrophages in the intestinal lamina propria contribute to gut homeostasis through the immunomodulatory interleukin IL10, but there is little knowledge on how these cells or the CX3CR1 receptor may affect colorectal carcinogenesis.
Twelve mature (aged 5–16 years) horses and ponies of mixed breed and type were fed restricted (1.25% BM Dry matter) quantities of one of two fiber based diets formulated to be iso-caloric.
Abstract Recent studies increasingly note the effect of captivity or the built environment on the microbiome of humans and other animals.
Highlights •For the first time galactomannan, derived from fenugreek and pectin, derived from citrus where shown to modulate gut microbiota and effect metabolic parameters and gene expression related to glucose metabolism.
Abstract Biological psychiatry research has long focused on the brain in elucidating the neurobiological mechanisms of anxiety- and trauma-related disorders.
Srimathy Sriskantharajah (BSc in Microbiology (UCL) and a PhD in environmental microbiology/ atmospheric chemistry (Royal Holloway University of London): Conducting research on Earth is challenging enough for most of us, but what if your research specialty is studying organisms in space?
From James Vitale, Marketing Program Director: Part I: Participants and Presentations This is the first of a three-part recap of Navigating the Challenges of Studying the Microbiome in Mouse Models: Design, Execution and Utility, a sponsored workshop at the 2017 Translational Microbiome Conference.
Highlights •Systematic analysis of longevity-promoting microbial genetic variations •Colanic acid as a pro-longevity natural compound effective in different species •Bacterial metabolites regulate host mitochondrial dynamics and UPRmit Summary Homeostasis of the gut microbiota critically influences host health and aging. Developing genetically engineered probiotics holds great promise as a new therapeutic paradigm to promote healthy aging.
The GMFH editing team recommends these book selections on the topic.
CS disaccharides may enhance intestinal absorption and promote kidney function.
Abstract Background Iron deficiency is common during infancy and therefore iron supplementation is recommended.
Arthur Beaudet discusses the importance of diet, genes, epigenetics, drugs, microbiome, and minor illnesses (especially gastrointestinal) in the hypothesis.
Highlights •Microbiome research will benefit from the complementary use of culture and molecular approaches.
Abstract In this chapter, we describe a fluorescence in vivo hybridization (FIVH) protocol, using nucleic acid probes, for the detection of the bacterium Helicobacter pylori in the gastric mucosa of an infected C57BL/6 mouse model.