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  • Nanoparticle relieved symptoms of inflammatory bowel disease in mice


    ANN ARBOR—Researchers at the University of Michigan College of Pharmacy have developed a nanoparticle that alters the gut microbiome and alleviates symptoms of inflammatory bowel disease in mice more effectively than common FDA-approved medications. The gut microbiome––the body’s environment of healthy and unhealthy bacteria––is the next frontier for drug development, and an imbalanced gut microbiome […]

  • FDA Issues Safety Alert on Investigational Use of Fecal Microbiota Transplantation


    Fecal microbiota transplantation (FMT) is the transfer of fecal matter from a healthy individual into a recipient with the goal of treating an ailment. In its simplest form FMT has been used to treat disease with reports detailing its use as far back as 1700 years ago in China1. Modern applications of this procedure have […]

  • New Mouse Model Predicts Two Clinical Trial Failures in Humans


    A new mouse model designed with a microbiome similar to that of wild mice may be a better predictor of human responses to some drugs than commonly used lab mice, according to a study published today in Science. The authors repeated two preclinical studies that had demonstrated positive results in mice only to fail when […]

  • Using a more diverse microbiome, scientists look to create a better lab mouse


    Lab mice are notoriously clean: To prevent introducing anything that could disrupt results, researchers house them in sterile conditions, and the food and water they ingest are monitored for extreme quality. This also means that the mice’s microbiomes — the cohort of microorganisms that reside within all animals and influence many body processes — have […]

  • Microbiomes of Lab Mice Take a Walk on the Wild Side


    National Institutes of Health scientists have developed a new mouse model that could help to improve the relevance of these invaluable laboratory test animals to human health and disease, and the development of human therapeutics. The new mice, which the researchers have called “wildlings”, have acquired the microbiomes of wild mice, but retain the genetics […]

  • Bone and the Microbiome Have a Brittle Relationship


    Laura McCabe had been living a dual professional life at Michigan State University for more than a decade, studying bone in her lab while teaching medical students gastrointestinal physiology in the classroom, when she came across a call for proposals from the Crohn’s and Colitis Foundation. Could researchers look into how inflammatory bowel diseases affect […]

  • World Microbiome Day 2019


    World Microbiome Day is on June 27th this year. World Microbiome Day began in 2018 to demonstrate its emergence as a subject with global impact. That impact is being felt across a variety of disciplines including science, medicine, and nutrition. This year’s theme is “Bacterial Resistance to Antibiotics” highlighting the need to better understand microbes. […]

  • Gut Microbe Takes a Share of Our Brain Meds


    Swallowing a drug can tilt the gut-brain axis, alleviating the symptoms of neurodegenerative diseases such as Parkinson’s. Yet the axis can resist tilting as though its orientation were maintained by hidden sources of inertia. Suspected inertial dampeners include gut microbes. Although gut microbes have been thought to metabolize and lessen the efficacy of levodopa, the […]

  • Language, numeracy and logic in microbiome science


    To deliver precision therapeutics, microbiome-based medicine will require precision of language, logic and numerical accuracy. Epidemiological lessons of the past suggest that attempts to link almost everything in modern life with the microbiome as a risk factor for disease, without rapprochement with plausible mechanisms, will generate controversy rather than consensus. Read more at Nature Reviews: […]

  • Murine Genetic Background has a Stronger Impact on the Composition of the Gut Microbiota than Maternal Inoculation or Exposure to Unlike Exogenous Microbiota


    ABSTRACT The gut microbiota is a complex ecosystem, affected by both environmental factors and host genetics. Here we aim at uncovering the bacterial taxa whose gut persistence is controlled by host genetic variation. We used a murine model based on inbred lines BALB/c and C57BL/6J and their F1 reciprocal hybrids (♀C57BL/6J×♂BALB/c; ♀BALB/c×♂C57BL/6J). To guarantee genetic […]

  • Whole Body Vibration-Induced Omental Macrophage Polarization and Fecal Microbiome Modification in a Murine Model


    ABSTRACT Human nutrient metabolism, developed millions of years ago, is anachronistic. Adaptive features that offered survival advantages are now great liabilities. The current dietary pattern, coupled with massively reduced physical activities, causes an epidemic of obesity and chronic metabolic diseases, such as type 2 diabetes mellitus. Chronic inflammation is a major contributing factor to the […]

  • Baseline microbiota composition modulates antibiotic-mediated effects on the gut microbiota and host


    ABSTRACT Background Normal mammalian development and homeostasis are dependent upon the gut microbiota. Antibiotics, essential for the treatment and prophylaxis of bacterial infections, can have collateral effects on the gut microbiota composition, which can in turn have far-reaching and potentially deleterious consequences for the host. However, the magnitude and duration of such collateral effects appear […]

  • Predominant Effect of Host Genetics on Levels of Lactobacillus johnsonii Bacteria in the Mouse Gut


    ABSTRACT The gut microbiota is strongly associated with the well-being of the host. Its composition is affected by environmental factors, such as food and maternal inoculation, while the relative impact of the host’s genetics have been recently uncovered. Here, we studied the effect of the host genetic background on the composition of intestinal bacteria in […]

  • Laboratory mice born to wild mice have natural microbiota and model human immune responses


    STRUCTURED ABSTRACT INTRODUCTION Laboratory mice are a mainstay of biomedical research and have been instrumental for many important discoveries in the field of immunology. However, there are also major limitations, including conflicting results rooted in divergent microbiota among research facilities and the limited ability to predict the complex immune responses of humans. Recent studies have […]

  • T cell–mediated regulation of the microbiota protects against obesity


    STRUCTURED ABSTRACT The gut microbial metagenome encodes a diverse array of functions that complement host genes involved in metabolism. In support of this idea, the gut microbiomes of obese individuals are characterized by reduced species richness and metabolic capacity. Thus, maintenance of the diversity and collective functional capacity of the microbiota is likely vital to […]

  • The gut microbiota influences skeletal muscle mass and function in mice


    ABSTRACT The functional interactions between the gut microbiota and the host are important for host physiology, homeostasis, and sustained health. We compared the skeletal muscle of germ-free mice that lacked a gut microbiota to the skeletal muscle of pathogen-free mice that had a gut microbiota. Compared to pathogen-free mouse skeletal muscle, germ-free mouse skeletal muscle […]

  • Loss of gut barrier integrity triggers activation of islet-reactive T cells and autoimmune diabetes


    Significance Functional loss of gut barrier integrity with subsequent increased antigen trafficking and occurrence of low-grade intestinal inflammation precede the onset of type 1 diabetes (T1D) in patients and preclinical models, thus suggesting that these events are mechanistically linked to the autoimmune pathogenesis of the disease. However, a causal relationship between increased intestinal permeability and […]

  • The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling


    ABSTRACT Symbiotic microbes impact the function and development of the central nervous system (CNS); however, little is known about the contribution of the microbiota during viral-induced neurologic damage. We identify that commensals aid in host defense following infection with a neurotropic virus through enhancing microglia function. Germfree mice or animals that receive antibiotics are unable […]

  • Events
    We maintain a calendar of events and meetings related to the field of Microbiome Research. Check it often for new events and conferences, or submit something for the calendar here.

  • Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice


    Significance Studies using experimental models have indicated that multiple sclerosis (MS)-like disease can be triggered in the gut following interactions of brain autoimmune T lymphocytes with local microbiota.

  • BOOK REVIEW: GNOTOBIOTICS


    Gnotobiotics, edited by Trenton Schoeb and Kathryn Eaton, is invaluable to those developing or managing gnotobiotic facilities.

  • Stress could be just as unhealthy as junk food


    Brigham Young University: We all know that a poor diet is unhealthy, but a new BYU study finds that stress may just as harmful to our bodies as a really bad diet.

  • Infection via mosquito bite alters Zika virus replication kinetics in rhesus macaques


    Abstract For more than three decades it has been recognized that small amounts of vector saliva can significantly alter the infectivity of vector-borne pathogens and subsequent in vivo dynamics.

  • Of Mice, Dirty Mice, and Men: Using Mice To Understand Human Immunology


    Abstract Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans.

  • Microbial Genetic Composition Tunes Host Longevity


    Highlights •Systematic analysis of longevity-promoting microbial genetic variations •Colanic acid as a pro-longevity natural compound effective in different species

  • Learning more about the gut microbiota


    The GMFH editing team recommends these book selections on the topic.

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