The Translational Microbiome Research Forum is an online resource for scientists engaged in translational microbiome research to access current, topical information and to provide a platform to exchange knowledge and ideas. We encourage you to participate by actively using the commenting system, by submitting links, resources, and your original research, and by joining our email list to receive updates when new content is posted.

  • The Metabolome: The Missing Link that Binds the Microbiome with Human Health
    human entrails under X-rays. 3d render.

    Researchers Need to Look at the Metabolome to Understand the Dynamic Relationship between the Microbiome and the Human Body.

  • Special Report on Microbiomics: The aliens within us

    Right now, as you read this article, you are under alien surveillance. If you lower these pages or raise your eyes from the computer screen, you may think you see your co-worker or life partner across the room, but none of these people are who they present themselves to be, or at least not fully.

  • No Known Expiration Date

    “Hell, no,” Richard Isaacson bellows when asked whether some form of cognitive decline is inevitable with age, especially for those genetically tilted toward the disabling dementia of Alzheimer’s disease. Then, in the interest of science, an enterprise customarily cloaked in the conjectural, he restrains himself.

  • Researchers Say Gut Microbiota Affects Our Physiology
    Escherichia coli, a gram-negative bacterium of the genus Escherichia that is commonly found in the lower intestine of warm-blooded organisms. Image credit: CDC.

    An international team of researchers from Spain and the UK has found that the protein TLR2 (Toll-like receptor 2) — a critical detector of the microbiota found in the intestine — regulates levels of serotonin, a neurotransmitter intimately connected to the brain’s regulation of appetite, sleep, and mood.

  • A Gut Makeover for the New Year

    If you’re making resolutions for a healthier new year, consider a gut makeover. Refashioning the community of bacteria and other microbes living in your intestinal tract, collectively known as the gut microbiome, could be a good long-term investment in your health.

  • Vitamin D Improves Gut Microbiota, Study Finds

    According to a study published in the journal Frontiers in Physiology, extra vitamin D can restore good bacteria in the gut, giving hope in the fight against risk factors for diabetes and heart disease.

  • Altered Microbiome Contributes to Exaggerated Post-Diet Weight Regain in Mice

    Obesity-associated microbiome composition can persist after weight loss, affecting the exchange of metabolites between a mouse and its resident bugs, researchers report.

  • How Diet Influences Host-Microbiome Communication in Mice

    Researchers are beginning to decipher the metabolic language of the microbiome, and determine how gut microbes communicate with host tissue. Shortly after we finish a good meal, our resident microbes spring into action. The bacteria, viruses, and fungi that inhabit our guts send out metabolites that prepare our organs for the incoming nutrients.

  • GEN Exclusives : Science in 2016 Was as Interesting as It Was Diverse

    Our single most popular news story of the year tackled the connection between the immune system and the brain.

  • Microbiome: Gut Bugs and You | Warren Peters | TEDxLaSierraUniversity

    Can gut bugs change the world? Join Warren Peters on a journey into understanding your microbiome and the new discoveries changing the way we understand diabetes, obesity, Alzheimer’s disease, autism, and our everyday health and wellness. Watch more at: YouTube

  • Calypso: a user-friendly web-server for mining and visualizing microbiome-environment interactions

    Abstract Calypso is an easy-to-use online software suite that allows non-expert users to mine, interpret and compare taxonomic information from metagenomic or 16S rDNA datasets.

  • Microbiome Sites

    NHGRI Image Gallery The NHGRI Image Gallery provides imagery related to the genomics research, people, and programs of the institute.

  • Probiotics Help Save the Spine

    Sounds of Science Podcast: A new study from investigators at The Ohio State University

  • Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

    For a detailed look at the state of the microbiome and its role in precision medicine, The Scientist is bringing together a panel of experts to share their research and discuss the next steps. FREE Webinar

  • Caltech Researchers Link Parkinson’s Disease to Gut Bacteria

    Professor Sarkis Mazmanian explains how he and postdoctoral scholar Tim Sampson discovered the link between the gut biome and Parkinson’s disease.

  • The Greatest Science Books of 2016

    Gathered here…a reflection on the reading most worth prioritizing in the year being left behind. “I have observed many tiny animals with great admiration,” Galileo marveled as he peered through his microscope

  • The Hungry Microbiome

    We’ve created a fascinating biomedical animation, The Hungry Microbiome, to bring to life years of scientific research and educate the public on how starch gets broken down in the gut.

  • The Microbiome Defined and Understood Using A.I.

    Some terminology just doesn’t sound that exciting. Take the term microbiome.

  • Viewpoint: The Microbiome and Risk for Obesity and Diabetes
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    Anthony L. Komaroff, MD, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, shares his viewpoint in JAMA. Published online December 22, 2016: Obesity and type 2 diabetes mellitus are influenced both by genes and lifestyle. That is not news. However, the genes in the human microbiome also may play an important role, and that […]

  • Metagenomics Expert Rita Colwell to Deliver Keynote Address at Arrowhead’s 3rd Annual Translational Microbiome Conference
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    The second keynote presentation at Arrowhead Publishers’ 3rd Annual Translational Microbiome Conference will be given by Dr. Rita Colwell, Distinguished Professor at Johns Hopkins Bloomberg School of Public Health and founder of CosmosID.

  • Events
    We maintain a calendar of events and meetings related to the field of Microbiome Research. Check it often for new events and conferences, or submit something for the calendar here.

  • Housing Systems Influence Gut Microbiota Composition of Sows but Not of Their Piglets

    Abstract Different housing systems can be used in pig production and little is known about their effect on gut microbiota composition. In this study we characterized fecal microbiota by sequencing the rRNA genes in sows kept during gestation in conventional pens with a slatted floor and in enriched pens with a floor covered with deep […]

  • Handling stress may confound murine gut microbiota studies

    ABSTRACT Background Accumulating evidence indicates interactions between human milk composition, particularly sugars (human milk oligosaccharides or HMO), the gut microbiota of human infants, and behavioral effects.

  • Interactions between host genetics and gut microbiome in diabetes and metabolic syndrome

    Abstract BACKGROUND: Diabetes, obesity, and the metabolic syndrome are multifactorial diseases dependent on a complex interaction of host genetics, diet, and other environmental factors.

  • Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Responses to Diet Interventions

    Highlights •Dietary practices can alter bacterial diversity in the human gut microbiota •Microbiota responses to diets vary in strength across individuals •Promoting bacterial dispersal between host microbiota enhances responses to diets •Metacommunity dynamics have implications for effective nutritional interventions

  • Vitamin D Signaling through Induction of Paneth Cell Defensins Maintains Gut Microbiota and Improves Metabolic Disorders and Hepatic Steatosis in Animal Models

    Abstract Metabolic syndrome (MetS), characterized as obesity, insulin resistance, and non-alcoholic fatty liver diseases (NAFLD), is associated with vitamin D insufficiency/deficiency in epidemiological studies, while the underlying mechanism is poorly addressed. On the other hand, disorder of gut microbiota, namely dysbiosis, is known to cause MetS and NAFLD.

  • Top Harvard Gazette story of 2016: Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

    Abstract Astrocytes have important roles in the central nervous system (CNS) during health and disease. Through genome-wide analyses we detected a transcriptional response to type I interferons (IFN-Is) in astrocytes during experimental CNS autoimmunity and also in CNS lesions from patients with multiple sclerosis (MS).

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