The publication of Translating microbiome futures is the culmination of more than a year’s work by Gaspar Taroncher-Oldenberg, Consultant in Residence at Global Engage and Susan Jones, Senior Editor at Nature Biotechnology. Together they spoke with close to 150 key opinion leaders in microbiome R&D, venture capital, and regulatory agencies. Then on May 23, 2018, […]
A mouse’s gut microbiome is, largely speaking, inherited and alters very little throughout multiple generations, according to a long-term study of caged wild mice published in Science today (October 25). While this vertical transmission predominates in the given experimental setup, the study also reveals that certain genera of bacteria could spread horizontally from cage to […]
Two extraordinary young scientists honored with prizes and more than $100,000 in support for research into the impacts of microbial communities on human health Hilden, Germany, and Germantown, Maryland, October 17, 2018 – QIAGEN today announced the winners of its fifth annual 2018 Microbiome Awards, a competition for outstanding researchers working on diverse aspects of […]
Gnotobiotic technology in laboratory animal science is the processes and systems employed for maintaining gnotobiotic and germfree (germfree) research animals. Through sterilization of feed and other husbandry supplies, and by housing in systems that completely protect the animals from the surrounding environment and human caretakers, the intent is to create and maintain animal models with […]
Submissions to the uBiome Clinical Outcomes in Microbial Genomics Innovation Challenge are now open, welcoming applications from healthcare providers, students, trainees, and researchers worldwide. Winning proposals will receive grants which include access to uBiome’s clinical testing kits, as well as microbiome sequencing and bioinformatics services. “uBiome is thrilled to further expand our collaborations in the […]
In a recent webinar, Dr. Alexander Rodriguez-Palacios of Case Western Reserve University School of Medicine discussed a confounding influence on many common microbiome study endpoints uncovered in studies using the NesTiso system. The NesTiso system has been described in a previous publication1 and examined in an on-demand webinar. There were several outstanding questions submitted by […]
I never thought I’d someday write the sentence, “I really enjoyed that FDA meeting.” But here I am doing just that. The topic of the meeting — regulatory implications of an emerging class of medicines to promote health by modulating the teeming microbial ecosystems that live inside each of us — may not sound like […]
Alterations in the microbiome have an acknowledged role in cancer pathology1,2. Earlier this year, however, researchers at New York University published a manuscript3 connecting the pancreatic microbiome to cancer progression. In this report, Pushalkar et al. demonstrate that the endogenous microbiome of the pancreas can drive immunosuppressive conditions in humans and mice, which creates a […]
The directors of the NIH funded Digestive Disease Research Core Centers (DDRCC) are conducting a survey to examine the perceptions of how animal husbandry and experimental practices influence microbiome data variability. DDRCC In March 2018, representatives from six of the eighteen DDRCC gathered for their annual Midwest Alliance meeting to discuss the latest findings in […]
ABSTRACT Toxoplasma gondii is a protozoan parasite with a predation-mediated transmission cycle between rodents and felines. Intermediate hosts acquire Toxoplasma by eating parasite cysts which invade the small intestine, disseminate systemically and finally establish host life-long chronic infection in brain and muscles. Here we show that Toxoplasma infection can trigger a severe form of sustained […]
ABSTRACT Intestinal mucus layer disruption and gut microflora modification in conjunction with tight junction (TJ) changes can increase colonic permeability that allows bacterial dissemination and intestinal and systemic disease. We showed previously that Citrobacter rodentium (CR)-induced colonic crypt hyperplasia and/or colitis is regulated by a functional cross-talk between the Notch and Wnt/β-catenin pathways. In the […]
ABSTRACT Humans with metabolic and inflammatory diseases frequently harbour lower levels of butyrate-producing bacteria in their gut. However, it is not known whether variation in the levels of these organisms is causally linked with disease development and whether diet modifies the impact of these bacteria on health. Here we show that a prominent gut-associated butyrate-producing […]
ABSTRACT Rodent models are invaluable to understanding health and disease in many areas of biomedical research. Unfortunately, many models suffer from lack of phenotype reproducibility. Our laboratory has shown that differences in gut microbiota (GM) can modulate phenotypes of models of colon cancer and inflammatory bowel disease. We and others have also shown that a […]
ABSTRACT The aim of this study was to examine the effect of exercise training and dietary supplementation of resveratrol on the composition of gut microbiota and to test the hypothesis that exercise training and resveratrol can prevent high‐fat diet (HFD)‐induced changes in the gut microbiota. Mice fed a HFD supplemented with resveratrol (4 g/kg food) […]
ABSTRACT Mammals house a diversity of bacteria that affect health in various ways, but the routes by which bacterial lineages are transmitted between hosts remain poorly understood. We experimentally determined microbiota transmission modes by deriving 17 inbred mouse lines from two wild populations and monitoring their gut microbiotas for up to 11 host generations. Individual- […]
ABSTRACT Real time in vivo methods are needed to better understand the interplay between diet and the gastrointestinal microbiota. Therefore, a rodent indirect calorimetry system was equipped with hydrogen (H2) and methane (CH4) sensors. H2 production was readily detected in C57BL/6J mice and followed a circadian rhythm. H2 production was increased within 12 hours after […]
ABSTRACT Age-related chronic inflammation is a major risk factor for the incidence and prevalence of age-related diseases, including infectious and neurodegenerative diseases. We previously reported that a lactic acid bacteria, Lactobacillus paracasei KW3110, activated macrophages and suppressed inflammation in mice and humans. In this study, we investigated whether long-term intake of heat-killed L. paracasei KW3110 […]
SUMMARY Dietary soluble fibers are fermented by gut bacteria into short-chain fatty acids (SCFA), which are considered broadly health-promoting. Accordingly, consumption of such fibers ameliorates metabolic syndrome. However, incorporating soluble fiber inulin, but not insoluble fiber, into a compositionally defined diet, induced icteric hepatocellular carcinoma (HCC). Such HCC was microbiota-dependent and observed in multiple strains […]
Significance Studies using experimental models have indicated that multiple sclerosis (MS)-like disease can be triggered in the gut following interactions of brain autoimmune T lymphocytes with local microbiota.
Gnotobiotics, edited by Trenton Schoeb and Kathryn Eaton, is invaluable to those developing or managing gnotobiotic facilities.
Brigham Young University: We all know that a poor diet is unhealthy, but a new BYU study finds that stress may just as harmful to our bodies as a really bad diet.
Abstract For more than three decades it has been recognized that small amounts of vector saliva can significantly alter the infectivity of vector-borne pathogens and subsequent in vivo dynamics.
Abstract Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans.
Highlights •Systematic analysis of longevity-promoting microbial genetic variations •Colanic acid as a pro-longevity natural compound effective in different species