The microbiome has an impact on every organ in the body. It is associated with every chronic disease that affects humans. For the past few years, research has focused on cataloguing what microbes are present on and in our bodies, and connecting those microbes to specific diseases. The next step is to find out how […]
Arrowhead Publishers has announced the return of their Nutrition track, sponsored by Reckitt Benckiser, to the 5th Annual Translational Microbiome Conference. This year’s nutrition track will have two complementary goals: to address the challenges faced by industry when undergoing clinical development for a microbiome-based intervention and current advances in the research, production and use of […]
ABSTRACT The study of microorganisms has been revolutionized by complementing the centuries-old art of microbiology with next-generation sequencing of complex bacterial communities (collectively termed “the microbiome”) within and around the eukaryotic host. Microbiome research initially focused on associations between certain microbial compositional features and human medical conditions. The field has quickly evolved, unraveling causative links […]
The BBVA Foundation Frontiers of Knowledge Award in the Biology and Biomedicine category has gone in this eleventh edition to American researcher Jeffrey Gordon, for his fundamental discovery of the importance of the gut microbial community to human health, in the words of the committee. “Gordon and his team were the first to demonstrate the […]
Rederiving murine research models is the process of transferring embryos from one animal into another which is either germ-free or hosts only specifically identified microbiota. This “resets” the health status of the line, allowing the offspring of mice or rats that were previously infected with either viruses, parasites, or bacteria to be used in research […]
An important new workshop is taking place at the 5th Annual Translational Microbiome Conference (Boston | April 16-18, 2019). Dr. Lakshmi Balanchandra, the Founder of the Women’s Venture Capital Network and an Assistant Professor of Entrepreneurship at Babson College’s Blank Center for Entrepreneurship, will be presenting What Investors Want, What Investors Notice and Value in […]
In 2018, the Gut Microbiota for Health (GMFH) digital community has reached an audience that includes scientists, healthcare professionals, and the general public, with 60,000 visits every month from all over the world. These changes reflect an increased awareness of how the gut microbiome influences health. Meanwhile, the number of publications focusing on the gut […]
In the last few months, multiple bacterial species have been making headlines. This review will outline three types of bacteria and how specific strains may prevent or encourage the development of bacterial infections: Escherichia coli (E. coli) is a gram-negative bacteria part of the Enterobacteriaceae family. E. coli in the Microbiome – Harmless strains of […]
Researchers from Stanford University published a paper in Science titled “Seasonal cycling in the gut microbiome of the Hadza hunter-gatherers of Tanzania” which examines the relationship between diet, seasons, and the microbiome. The authors performed a longitudinal study on 350 stool samples collected throughout a year and a half and found that the microbial population […]
Abstract Acarbose is a safe and effective medication for type 2 diabetes that inhibits host glucoamylases to prevent starch digestion in the small intestines and thus decrease postprandial blood glucose levels. This results in an increase in dietary starch in the distal intestine, where it becomes food for the gut bacterial community. Here, we examined […]
ABSTRACT Veterinary tetracycline drugs are emerging organic pollutants detected at high concentrations in the urine of school children and a potential public health risk. However, the implications of early-life exposure to tetracyclines on testosterone production, being new endocrine disruptors, remain unknown. We investigated whether the early-life exposure to low-doxycycline, a widely used tetracycline, on mitochondria […]
ABSTRACT Objective The gut microbiota is an important influencing factor of metabolic health. Although dietary interventions with probiotics, prebiotics, and synbiotics can be effective means to regulate obesity and associated comorbidities, the underlying shifts in gut microbial communities, especially at the functional level, have not been characterized in great details. In this study, we sought […]
ABSTRACT Arsenic poisons an estimated 200 million people worldwide through contaminated food and drinking water. Confusingly, the gut microbiome has been suggested to both mitigate and exacerbate arsenic toxicity. Here, we show that the microbiome protects mice from arsenic-induced mortality. Both antibiotic-treated and germ-free mice excrete less arsenic in stool and accumulate more arsenic in […]
SUMMARY Lung cancer is closely associated with chronic inflammation, but the causes of inflammation and the specific immune mediators have not been fully elucidated. The lung is a mucosal tissue colonized by a diverse bacterial community, and pulmonary infections commonly present in lung cancer patients are linked to clinical outcomes. Here, we provide evidence that […]
ABSTRACT Central estrogen signaling coordinates energy expenditure, reproduction, and in concert with peripheral estrogen impacts skeletal homeostasis in females. Here, we ablate estrogen receptor alpha (ERα) in the medial basal hypothalamus and find a robust bone phenotype only in female mice that results in exceptionally strong trabecular and cortical bones, whose density surpasses other reported […]
ABSTRACT There is a growing appreciation for the importance of the gut microbiota as a therapeutic target in various diseases. However, there are only a handful of known commensal strains that can potentially be used to manipulate host physiological functions. Here we isolate a consortium of 11 bacterial strains from healthy human donor faeces that […]
ABSTRACT Obesity and type 2 diabetes are increasing in prevalence around the world, and there is a clear need for new and effective strategies to promote metabolic health. A low protein (LP) diet improves metabolic health in both rodents and humans, but the mechanisms that underlie this effect remain unknown. The gut microbiome has recently […]
ABSTRACT Asperlin is a marine-derived, natural product with antifungal, anti-inflammatory and anti-atherosclerotic activities. In the present study, we showed that asperlin effectively prevented the development of obesity in high-fat diet (HFD)-fed mice. Oral administration of asperlin for 12 weeks significantly suppressed HFD-induced body weight gain and fat deposition without inhibiting food intake. Hyperlipidemia and liver […]
Significance Studies using experimental models have indicated that multiple sclerosis (MS)-like disease can be triggered in the gut following interactions of brain autoimmune T lymphocytes with local microbiota.
Gnotobiotics, edited by Trenton Schoeb and Kathryn Eaton, is invaluable to those developing or managing gnotobiotic facilities.
Brigham Young University: We all know that a poor diet is unhealthy, but a new BYU study finds that stress may just as harmful to our bodies as a really bad diet.
Abstract For more than three decades it has been recognized that small amounts of vector saliva can significantly alter the infectivity of vector-borne pathogens and subsequent in vivo dynamics.
Abstract Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans.
Highlights •Systematic analysis of longevity-promoting microbial genetic variations •Colanic acid as a pro-longevity natural compound effective in different species