The Translational Microbiome Research Forum is an online resource for scientists engaged in translational microbiome research to access current, topical information and to provide a platform to exchange knowledge and ideas. We encourage you to participate by actively using the commenting system, by submitting events, and by joining our email list to receive updates when new content is posted.

  • On-Demand Webinar – Nested Isolation: A Low-Cost Housing Strategy to Boost Microbiome Research Capabilities


    Watch Taconic Biosciences’ new webinar, Nested Isolation: A Low-Cost Housing Strategy to Boost Microbiome Research Capabilities, to learn how Nested isolation works. Nested isolation – or NesTiso – is a technique that not only delivers the same results as a full gnotobiotic core, but with commonly accessible equipment and dramatically improved usability. Presented by Alexander […]

  • Introduction to Translational Microbiome Research Infographic


    Download Taconic Biosciences’ new infographic, Translational Microbiome at a Glance, for valuable insights into the translational aspects of microbiome research. Intended for those just beginning their work, Translational Microbiome at a Glance covers critical introductory subjects such as: The six factors that shape the mouse microbiome — and study endpoints Disease associations that can impact […]

  • Limitations of Feces as Proxy for Gut Microbiota


    A myriad of factors can influence the gut microbiota composition of laboratory rats and mice: diet, stress, circadian rhythm, vendor source, how they are housed, and more. Since different gut microbiota compositions can elicit different phenotypes under otherwise similar experimental conditions, understanding what shapes the rodent microbiome is becoming increasingly important for researchers. Husbandry-Induced Microbiome […]

  • Feed Your Gut Microbiota for Improved Health


    Clostridium difficile is a significant source of infectious disease death in the United States, and C. difficile infection can be difficult to treat. Many researchers are focusing on new therapies for this major health problem, including clinical use of fecal microbiota transplantation. Dietary manipulations are another avenue of study. Researchers at the Stanford University School […]

  • A wide-ranging text synthesizes what we know (and don’t know) about the microbiome


    Angela Douglas is an internationally recognized expert on symbiosis, with a number of foundational texts to her name (1, 2). In her new book, Fundamentals of Microbiome Science, Douglas synthetizes data from the burgeoning field of microbiome science in eight highly informative chapters. Topics include the origins of the animal microbiome, what we know about […]

  • Gordon receives British Royal Society’s highest honor


    Jeffrey I. Gordon, MD, of Washington University School of Medicine in St. Louis, has received the 2018 Copley Medal from the Royal Society in Britain. He is being honored for his studies of human gut microbial communities, which have led to a fundamental shift in the way scientists understand the relationship between microbes, health and […]

  • Microbiomania: what we actually know about the human microbiome

    Lance Armstrong may not have tried it, but poo doping is the new item of discussion on the performance enhancement menu. It turns out elite cyclists have a couple of critters in their gut that might boost performance. The discovery began three years ago, when Lauren Petersen, a researcher at The Jackson Laboratory for Genomic […]

  • The Gut Microbiome: Markers of Human Health, Drug Efficacy and Xenobiotic Toxicity

    The gut microbiome is believed to play an important role in human health in areas as diverse as brain function and the immune system. Exploring host-microbiome interactions will provide a mechanistic understanding and enable new insights in human diseases (i.e., their diagnosis, prognosis and treatment) and new perceptions of xenobiotic efficacy and/or toxicity. This workshop […]

  • Diets High in Salt May Increase Sensitivity to Autoimmune Disease through Microbiome Alteration


    High salt diets have previously been shown to increase severity of certain types of induced autoimmune disease in mouse models via a signaling pathway, but the impact of these diets on the gut microbiome and intestinal inflammation have not been studied. Researchers at McMaster University recently investigated this question in a paper titled “High salt […]

  • Non-nutritive sweeteners possess a bacteriostatic effect and alter gut microbiota in mice


    ABSTRACT Non-nutritive sweeteners (NNSs) are widely used in various food products and soft drinks. There is growing evidence that NNSs contribute to metabolic dysfunction and can affect body weight, glucose tolerance, appetite, and taste sensitivity. Several NNSs have also been shown to have major impacts on bacterial growth both in vitro and in vivo. Here […]

  • Oral infection of mice with Fusobacterium nucleatum results in macrophage recruitment to the dental pulp and bone resorption


    ABSTRACT Background Fusobacterium nucleatum is a Gram-negative anaerobic bacterium associated with periodontal disease. Some oral bacteria, like Porphyromonas gingivalis, evade the host immune response by inhibiting inflammation. On the other hand, F. nucleatum triggers inflammasome activation and release of danger-associated molecular patterns (DAMPs) in infected gingival epithelial cells. Methods In this study, we characterized the […]

  • Aryl hydrocarbon receptor/IL-22/Stat3 signaling pathway is involved in the modulation of intestinal mucosa antimicrobial molecules by commensal microbiota in mice.

    ABSTRACT Compelling evidence demonstrates the crucial role of the commensal microbiota in host physiology and the detrimental effects of its perturbations following antibiotic treatment. However, the effects of commensal microbiota on intestinal mucosa antimicrobial molecules have not been elucidated systematically. Here, we investigate the impacts of antibiotic-induced depletion and subsequent restoration of the intestinal microbiota […]

  • Development of outbred CD1 mouse colonies with distinct standardized gut microbiota profiles for use in complex microbiota targeted studies


    ABSTRACT Studies indicate that the gut microbiota (GM) can significantly influence both local and systemic host physiologic processes. With rising concern for optimization of experimental reproducibility and translatability, it is essential to consider the GM in study design. However, GM profiles can vary between rodent producers making consistency between models challenging. To circumvent this, we […]

  • Magnesium lithospermate B improves the gut microbiome and bile acid metabolic profiles in a mouse model of diabetic nephropathy


    ABSTRACT Magnesium lithospermate B (MLB) is a new drug marketed in China to treat angina, but its low oral bioavailability limits its clinical application to the intravenous route. Paradoxically, orally administered low-dose MLB was found to alleviate kidney injury in diabetic nephropathy (DN) rats, but its mechanism of action remains unknown. In recent years, the […]

  • Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism


    ABSTRACT Obesity and diabetes in humans are associated with increased rates of anxiety and depression. To understand the role of the gut microbiome and brain insulin resistance in these disorders, we evaluated behaviors and insulin action in brain of mice with diet-induced obesity (DIO) with and without antibiotic treatment. We find that DIO mice have […]

  • Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion


    ABSTRACT Tryptamine, a tryptophan-derived monoamine similar to 5-hydroxytryptamine (5-HT), is produced by gut bacteria and is abundant in human and rodent feces. However, the physiologic effect of tryptamine in the gastrointestinal (GI) tract remains unknown. Here, we show that the biological effects of tryptamine are mediated through the 5-HT4 receptor (5-HT4R), a G-protein-coupled receptor (GPCR) […]

  • A dietary isothiocyanate-enriched moringa (Moringa oleifera) seed extract improves glucose tolerance in a high-fat-diet mouse model and modulates the gut microbiome


    ABSTRACT Moringa oleifera (moringa) has been traditionally used for the treatment of diabetes and in water purification. We previously showed that moringa seed extract (MSE), standardized to its primary bioactive isothiocyanate (MIC-1), modulated inflammatory and antioxidant signaling pathways in vitro. To understand the efficacy and mechanisms of action of MSE in vivo, we incorporated MSE […]

  • The enteric microbiota regulates jejunal Paneth cell number and function without impacting intestinal stem cells

    ABSTRACT Paneth cells (PCs) are epithelial cells found in the small intestine, next to intestinal stem cells (ISCs) at the base of the crypts. PCs secrete antimicrobial peptides (AMPs) that regulate the commensal gut microbiota. In contrast, little is known regarding how the enteric microbiota reciprocally influences PC function. In this study, we sought to […]

  • Events
    We maintain a calendar of events and meetings related to the field of Microbiome Research. Check it often for new events and conferences, or submit something for the calendar here.

  • Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice


    Significance Studies using experimental models have indicated that multiple sclerosis (MS)-like disease can be triggered in the gut following interactions of brain autoimmune T lymphocytes with local microbiota.

  • BOOK REVIEW: GNOTOBIOTICS


    Gnotobiotics, edited by Trenton Schoeb and Kathryn Eaton, is invaluable to those developing or managing gnotobiotic facilities.

  • Stress could be just as unhealthy as junk food


    Brigham Young University: We all know that a poor diet is unhealthy, but a new BYU study finds that stress may just as harmful to our bodies as a really bad diet.

  • Infection via mosquito bite alters Zika virus replication kinetics in rhesus macaques


    Abstract For more than three decades it has been recognized that small amounts of vector saliva can significantly alter the infectivity of vector-borne pathogens and subsequent in vivo dynamics.

  • Of Mice, Dirty Mice, and Men: Using Mice To Understand Human Immunology


    Abstract Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans.

  • Microbial Genetic Composition Tunes Host Longevity


    Highlights •Systematic analysis of longevity-promoting microbial genetic variations •Colanic acid as a pro-longevity natural compound effective in different species

  • Learning more about the gut microbiota


    The GMFH editing team recommends these book selections on the topic.

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