The Translational Microbiome Research Forum is an online resource for scientists engaged in translational microbiome research to access current, topical information and to provide a platform to exchange knowledge and ideas. We encourage you to participate by actively using the commenting system, by submitting events, and by joining our email list to receive updates when new content is posted.

  • Depression and the Microbiome

    New research is regularly being published on the connection between the gut microbiome and the central nervous system (CNS) — together known as the gut-brain axis. Alterations in the composition of intestinal microbiota have also been associated with antibiotic use and the progression of infectious diseases. This Taconic Insight highlights the link between the microbiome […]

  • A review of 10 years of human microbiome research activities at the US National Institutes of Health, Fiscal Years 2007-2016

    The National Institutes of Health (NIH) is the primary federal government agency for biomedical research in the USA. NIH provides extensive support for human microbiome research with 21 of 27 NIH Institutes and Centers (ICs) currently funding this area through their extramural research programs. This analysis of the NIH extramural portfolio in human microbiome research […]

  • University of Calgary to lead pan-Canadian microbiome research core

    The microbiome has an impact on every organ in the body. It is associated with every chronic disease that affects humans. For the past few years, research has focused on cataloguing what microbes are present on and in our bodies, and connecting those microbes to specific diseases. The next step is to find out how […]

  • Overcoming Challenges in the Clinical Development of Nutrition-Related Microbiome Interventions

    Arrowhead Publishers has announced the return of their Nutrition track, sponsored by Reckitt Benckiser, to the 5th Annual Translational Microbiome Conference. This year’s nutrition track will have two complementary goals: to address the challenges faced by industry when undergoing clinical development for a microbiome-based intervention and current advances in the research, production and use of […]

  • Transforming medicine with the microbiome

    ABSTRACT The study of microorganisms has been revolutionized by complementing the centuries-old art of microbiology with next-generation sequencing of complex bacterial communities (collectively termed “the microbiome”) within and around the eukaryotic host. Microbiome research initially focused on associations between certain microbial compositional features and human medical conditions. The field has quickly evolved, unraveling causative links […]

  • Jeffrey Gordon wins the Frontiers of Knowledge Award for pioneering microbiome research

    The BBVA Foundation Frontiers of Knowledge Award in the Biology and Biomedicine category has gone in this eleventh edition to American researcher Jeffrey Gordon, for his fundamental discovery of the importance of the gut microbial community to human health, in the words of the committee. “Gordon and his team were the first to demonstrate the […]

  • Rederivation of Mouse Models at Higher Health Statuses

    Rederiving murine research models is the process of transferring embryos from one animal into another which is either germ-free or hosts only specifically identified microbiota. This “resets” the health status of the line, allowing the offspring of mice or rats that were previously infected with either viruses, parasites, or bacteria to be used in research […]

  • The Secrets of Successful Venture Pitching: A New Workshop at the 5th Annual Translational Microbiome Conference

    An important new workshop is taking place at the 5th Annual Translational Microbiome Conference (Boston | April 16-18, 2019). Dr. Lakshmi Balanchandra, the Founder of the Women’s Venture Capital Network and an Assistant Professor of Entrepreneurship at Babson College’s Blank Center for Entrepreneurship, will be presenting What Investors Want, What Investors Notice and Value in […]

  • The most significant achievements in gut microbiome science in 2018

    In 2018, the Gut Microbiota for Health (GMFH) digital community has reached an audience that includes scientists, healthcare professionals, and the general public, with 60,000 visits every month from all over the world. These changes reflect an increased awareness of how the gut microbiome influences health. Meanwhile, the number of publications focusing on the gut […]

  • Six‐Week High‐Fat Diet Alters the Gut Microbiome and Promotes Cecal Inflammation, Endotoxin Production, and Simple Steatosis without Obesity in Male Rats

    ABSTRACT Energy‐dense foods can alter gut microbial diversity. However, the physiological effects of diet‐induced microbial changes on the development of nonalcoholic fatty liver disease (NAFLD) remain debatable. We hypothesized that high‐fat intake for 6 weeks would promote intestinal dysbiosis by increasing gram‐positive bacteria, inducing the intestinal production of proinflammatory cytokines and subsequent hepatic lipid infiltration in […]

  • The gut microbiota regulates mouse biliary regenerative responses

    ABSTRACT Injury to the biliary epithelium triggers cholangiopathies. However, factors involved in regulating the pathogenesis remains incompletely understood. Here, we report that the gut microbiota is important in regulating hepatobiliary fibroproliferative regenerative process. In helminth Clonorchis sinensis-induced bile duct injury model, wild-type mice showed more extensive peribiliary fibroproliferative responses than non-littermate IL-33-deficient mice. However, these […]

  • Microbiota Depletion Impairs Thermogenesis of Brown Adipose Tissue and Browning of White Adipose Tissue

    SUMMARY The relation between gut microbiota and the host has been suggested to benefit metabolic homeostasis. Brown adipose tissue (BAT) and beige adipocytes facilitate thermogenesis to maintain host core body temperature during cold exposure. However, the potential impact of gut microbiota on the thermogenic process is confused. Here, we evaluated how BAT and white adipose […]

  • The gut microbiota composition affects dietary polyphenols-mediated cognitive resilience in mice by modulating the bioavailability of phenolic acids

    ABSTRACT Dietary polyphenols promote memory in models of sleep deprivation (SD), stress, and neurodegeneration. The biological properties of dietary polyphenols greatly depend upon the bioavailability of their phenolic metabolites derivatives, which are modulated by gut microbiota. We recently demonstrated that supplementation with grape-derived bioactive dietary polyphenol preparation (BDPP) improves SD-induced cognitive impairment. This study examined […]

  • Helminth-Based Product and the Microbiome of Mice with Lupus

    ABSTRACT The hygiene hypothesis claims that the lack of exposure to microorganisms in developed countries correlates with a rise in the incidence of autoimmune diseases. It was also found that helminths are able to modulate the immune response in hosts in order to survive. Consequently, several successful trials using helminths as a treatment for autoimmune […]

  • Alterations of the mice gut microbiome via Schistosoma japonicum ova-induced granuloma

    ABSTRACT Schistosomiasis, also called bilharziasis, is a neglected tropical disease induced by Schistosoma spp. that causes hundreds of millions of infections. Although Schistosoma ova-induced granulomas commonly cause inflammation, hyperplasia, ulceration, microabscess formation, and polyposis, the role of the egg granuloma on the gut microbiome remains unclear. To explore the role, gut microbial communities in mice […]

  • Helminth-Based Product and the Microbiome of Mice with Lupus

    ABSTRACT The hygiene hypothesis claims that the lack of exposure to microorganisms in developed countries correlates with a rise in the incidence of autoimmune diseases. It was also found that helminths are able to modulate the immune response in hosts in order to survive. Consequently, several successful trials using helminths as a treatment for autoimmune […]

  • Western diet regulates immune status and the response to LPS-driven sepsis independent of diet-associated microbiome

    ABSTRACT Sepsis is a deleterious immune response to infection that leads to organ failure and is the 11th most common cause of death worldwide. Despite plaguing humanity for thousands of years, the host factors that regulate this immunological response and subsequent sepsis severity and outcome are not fully understood. Here we describe how the Western […]

  • The Glucoamylase Inhibitor Acarbose Has a Diet-Dependent and Reversible Effect on the Murine Gut Microbiome

    Abstract Acarbose is a safe and effective medication for type 2 diabetes that inhibits host glucoamylases to prevent starch digestion in the small intestines and thus decrease postprandial blood glucose levels. This results in an increase in dietary starch in the distal intestine, where it becomes food for the gut bacterial community. Here, we examined […]

  • Events
    We maintain a calendar of events and meetings related to the field of Microbiome Research. Check it often for new events and conferences, or submit something for the calendar here.

  • Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice

    Significance Studies using experimental models have indicated that multiple sclerosis (MS)-like disease can be triggered in the gut following interactions of brain autoimmune T lymphocytes with local microbiota.


    Gnotobiotics, edited by Trenton Schoeb and Kathryn Eaton, is invaluable to those developing or managing gnotobiotic facilities.

  • Stress could be just as unhealthy as junk food

    Brigham Young University: We all know that a poor diet is unhealthy, but a new BYU study finds that stress may just as harmful to our bodies as a really bad diet.

  • Infection via mosquito bite alters Zika virus replication kinetics in rhesus macaques

    Abstract For more than three decades it has been recognized that small amounts of vector saliva can significantly alter the infectivity of vector-borne pathogens and subsequent in vivo dynamics.

  • Of Mice, Dirty Mice, and Men: Using Mice To Understand Human Immunology

    Abstract Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans.

  • Microbial Genetic Composition Tunes Host Longevity

    Highlights •Systematic analysis of longevity-promoting microbial genetic variations •Colanic acid as a pro-longevity natural compound effective in different species

  • Learning more about the gut microbiota

    The GMFH editing team recommends these book selections on the topic.

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