The Translational Microbiome Research Forum is an online resource for scientists engaged in translational microbiome research to access current, topical information and to provide a platform to exchange knowledge and ideas. We encourage you to participate by actively using the commenting system, by submitting events, and by joining our email list to receive updates when new content is posted.

  • Animal Husbandry in Microbiome Research: 2018 RIGOR & REPRODUCIBILITY SURVEY


    The directors of the NIH funded Digestive Disease Research Core Centers (DDRCC) are conducting a survey to examine the perceptions of how animal husbandry and experimental practices influence microbiome data variability. DDRCC In March 2018, representatives from six of the eighteen DDRCC gathered for their annual Midwest Alliance meeting to discuss the latest findings in […]

  • Webinar Q&A — Nested Isolation


    In a recent webinar, Dr. Alex Rodriguez-Palacios of Case Western Reserve University School of Medicine discussed the use of a new, low-cost caging system for conducting microbiome research in rodents. The speaker shared their experience with the NesTiso system and discussed: How NesTiso makes gnotobiotic research simple and practical How to inexpensively verify the germ-free […]

  • Book Review: Animal Models for Microbiome Research


    This book is the outcome of Workshop on Animal Models for Microbiome Research: Advancing Basic Science and Translational Research, hosted by the Institute for Laboratory Animal Research (ILAR). Microbiome and germ-free researchers James Fox, Joseph Newsome, Wendy Garrett, Jeffrey Gordon and Vincent Young organized the workshop, with the following goals: Improve the depth and breadth […]

  • Humanizing the gut microbiota of mice: Opportunities and challenges


    On August 8, 2018, Randi Lundberg, DVM, PhD published a review paper titled, Humanizing the gut microbiota of mice: Opportunities and challenges in the journal, Laboratory Animals. The author acknowledges the need for in vivo models to study the human microbiome’s interaction with a biologically relevant host. Mice are one of the most popular animal […]

  • 4 Gut-Brain Axis Publications You May Have Missed


    You may have missed these publications in the recent rush of microbiome and germ-free research news, but researchers are making interesting connections between the gut microbiome and neurological functioning. Four studies examined relationships between the gut microbiome and mood, behavior, disease risk, and development. Prenatal Stress, the Microbiome, and Development Scientists at Ohio State University’s […]

  • Top 10 Summer Science Reads


    Heading off on vacation? Pack your beach bag with one of these 10 cutting-edge scientific books to keep your mind active this summer: Pandora’s Lab: Seven Stories of Science Gone Wrong, by Paul A. Offit MD The Hidden Half of Nature: The Microbial Roots of Life and Health, by David R. Montgomery and Anne Bikle […]

  • New Research on Maintaining Complex Gut Microbiota in Mouse Models


    An increased interest in studies involving the microbiota requires animal models that appropriately mimic the extremely complex normal gut microbiota. Differences in rodent models can have a negative impact on a study’s reproducibility. On July 4, 2018, researchers at the University of Missouri, University of California, Davis, and University of North Carolina at Chapel Hill […]

  • On-Demand Webinar: Cyclical Bias and Variability in Microbiome Research


    While developing a novel gnotobiotic housing strategy, researchers on the Nested Isolation project discovered a cyclical bias in the microbiome composition of animals in SPF cages. These changes in microbiota could influence phenotype and confound study endpoints, with implications for the reproducibility of some gnotobiotic research. How can you best identify and control for cyclical […]

  • A single genetic change in gut bacteria alters host metabolism


    Scientists have found that deleting a single gene in a particular strain of gut bacteria causes changes in metabolism and reduced weight gain in mice, according to a study in the journal eLife. The research provides an important step towards understanding how the microbiome – the bacteria that live in our body – affects metabolism. […]

  • The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice


    ABSTRACT Interactions between the gut microbial ecosystem and host lipid homeostasis are highly relevant to host physiology and metabolic diseases. We present a comprehensive multi-omics view of the effect of intestinal microbial colonization on hepatic lipid metabolism, integrating transcriptomic, proteomic, phosphoproteomic, and lipidomic analyses of liver and plasma samples from germfree and specific pathogen-free mice. […]

  • An experimental murine model to study periodontitis


    ABSTRACT Periodontal disease (PD) is a common dental disease associated with the interaction between dysbiotic oral microbiota and host immunity. It is a prevalent disease, resulting in loss of gingival tissue, periodontal ligament, cementum and alveolar bone. PD is a major form of tooth loss in the adult population. Experimental animal models have enabled the […]

  • Characterization of the Functional Changes in Mouse Gut Microbiome Associated with Increased Akkermansia muciniphila Population Modulated by Dietary Black Raspberries


    ABSTRACT Gut microbiome plays an essential role in host health through host–gut microbiota metabolic interactions. Desirable modulation of beneficial gut bacteria, such as Akkermansia muciniphila, can confer health benefits by altering microbiome-related metabolic profiles. The purpose of this study is to examine the effects of a black raspberry-rich diet to reshape the gut microbiome by […]

  • Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT


    SUMMARY Probiotics are widely prescribed for prevention of antibiotics-associated dysbiosis and related adverse effects. However, probiotic impact on post-antibiotic reconstitution of the gut mucosal host-microbiome niche remains elusive. We invasively examined the effects of multi-strain probiotics or autologous fecal microbiome transplantation (aFMT) on post-antibiotic reconstitution of the murine and human mucosal microbiome niche. Contrary to […]

  • Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features


    SUMMARY Empiric probiotics are commonly consumed by healthy individuals as means of life quality improvement and disease prevention. However, evidence of probiotic gut mucosal colonization efficacy remains sparse and controversial. We metagenomically characterized the murine and human mucosal-associated gastrointestinal microbiome and found it to only partially correlate with stool microbiome. A sequential invasive multi-omics measurement […]

  • Intestinal Pathology and Gut Microbiota Alterations in a Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Mouse Model of Parkinson’s Disease

    ABSTRACT Patients with Parkinson’s disease (PD) often have non-motor symptoms related to gastrointestinal (GI) dysfunction, such as constipation and delayed gastric emptying, which manifest prior to the motor symptoms of PD. Increasing evidence indicates that changes in the composition of the gut microbiota may be related to the pathogenesis of PD. However, it is unclear […]

  • Effects of Natural Flavonoid-Isoorientin on Growth Performance and Gut Microbiota of Mice

    ABSTRACT Isoorientin (ISO) is a natural flavonoid which is a 6-C-glucoside of luteolin and has been demonstrated to possess the multiple biological properties. In this study, the effects of ISO on the growth performance and gut microbiota of BALB/c mice were investigated. The results showed that ISO could promote food intake and body weight gain, […]

  • Differential effects of psychotropic drugs on microbiome composition and gastrointestinal function

    Rationale Growing evidence supports a role for the microbiota in regulating gut-brain interactions and, thus, psychiatric disorders. Despite substantial scientific efforts to delineate the mechanism of action of psychotropic medications at a central nervous system (CNS) level, there remains a critical lack of understanding on how these drugs might affect the microbiota and gut physiology. […]

  • Microbial Sensing by Intestinal Myeloid Cells Controls Carcinogenesis and Epithelial Differentiation


    Physiologic microbe-host interactions in the intestine require the maintenance of the microbiota in a luminal compartment through a complex interplay between epithelial and immune cells. However, the roles of mucosal myeloid cells in this process remain incompletely understood. In this study, we identified that decreased myeloid cell phagocytic activity promotes colon tumorigenesis. We show that […]

  • Events
    We maintain a calendar of events and meetings related to the field of Microbiome Research. Check it often for new events and conferences, or submit something for the calendar here.

  • Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice


    Significance Studies using experimental models have indicated that multiple sclerosis (MS)-like disease can be triggered in the gut following interactions of brain autoimmune T lymphocytes with local microbiota.

  • BOOK REVIEW: GNOTOBIOTICS


    Gnotobiotics, edited by Trenton Schoeb and Kathryn Eaton, is invaluable to those developing or managing gnotobiotic facilities.

  • Stress could be just as unhealthy as junk food


    Brigham Young University: We all know that a poor diet is unhealthy, but a new BYU study finds that stress may just as harmful to our bodies as a really bad diet.

  • Infection via mosquito bite alters Zika virus replication kinetics in rhesus macaques


    Abstract For more than three decades it has been recognized that small amounts of vector saliva can significantly alter the infectivity of vector-borne pathogens and subsequent in vivo dynamics.

  • Of Mice, Dirty Mice, and Men: Using Mice To Understand Human Immunology


    Abstract Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans.

  • Microbial Genetic Composition Tunes Host Longevity


    Highlights •Systematic analysis of longevity-promoting microbial genetic variations •Colanic acid as a pro-longevity natural compound effective in different species

  • Learning more about the gut microbiota


    The GMFH editing team recommends these book selections on the topic.

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