Microbial Genetic Composition Tunes Host Longevity

Highlights •Systematic analysis of longevity-promoting microbial genetic variations •Colanic acid as a pro-longevity natural compound effective in different species •Bacterial metabolites regulate host mitochondrial dynamics and UPRmit Summary Homeostasis of the gut microbiota critically influences host health and aging. Developing genetically engineered probiotics holds great promise as a new therapeutic paradigm to promote healthy aging.

Learning more about the gut microbiota

The GMFH editing team recommends these book selections on the topic.

Chondroitin sulfate disaccharides modified the structure and function of the murine gut microbiome under healthy and stressed conditions

CS disaccharides may enhance intestinal absorption and promote kidney function.

Effects of iron supplementation on growth, gut microbiota, metabolomics and cognitive development of rat pups

Abstract Background Iron deficiency is common during infancy and therefore iron supplementation is recommended.

VIDEO: BioEssays: Brain carnitine deficiency causes nonsyndromic autism with an extreme male bias

Arthur Beaudet discusses the importance of diet, genes, epigenetics, drugs, microbiome, and minor illnesses (especially gastrointestinal) in the hypothesis.

From complex gut communities to minimal microbiomes via cultivation

Highlights •Microbiome research will benefit from the complementary use of culture and molecular approaches.

Detection of Helicobacter pylori in the Gastric Mucosa by Fluorescence In Vivo Hybridization

Abstract In this chapter, we describe a fluorescence in vivo hybridization (FIVH) protocol, using nucleic acid probes, for the detection of the bacterium Helicobacter pylori in the gastric mucosa of an infected C57BL/6 mouse model.


A periodic list of methods, tools and people driving research and development. Our scientists present 10 tools and strategies helping to advance immuno-oncology

Harnessing the Power of PCR Molecular Fingerprinting Methods and Next Generation Sequencing for Understanding Structure and Function in Microbial Communities

Abstract Polymerase chain reaction (PCR) is central to methods in molecular ecology. Here, we describe PCR-dependent approaches useful for investigating microbial diversity and its function in various natural, human-associated, and built environment ecosystems.

Involvement of a gut–retina axis in protection against dietary glycemia-induced age-related macular degeneration

Significance Food is medicine, and diet impacts the risk for and progression of age-related macular degeneration AMD, but we have few clues as to why. We found that wild-type mice fed a high-glycemic-index diet similar in composition to the Western diet developed a disease state that resembles dry AMD.

SteadyCom: Predicting microbial abundances while ensuring community stability

Abstract Genome-scale metabolic modeling has become widespread for analyzing microbial metabolism. Extending this established paradigm to more complex microbial communities is emerging as a promising way to unravel the interactions and biochemical repertoire of these omnipresent systems.

Optical nanofiber ‘hears’ bacteria swim, cancer cells move

At the macroscopic level that’s familiar to us, birds chirp, whales sing and we talk. But at the microscopic level, our cells pulsate, bacteria swim and pressure waves ripple on a scale we can’t reach.

Dirt Is Good: The Advantage of Germs for Your Child’s Developing Immune System

by Jack Gilbert (Author), Rob Knight (Author) From two of the world’s top scientists


Dr. Michael Pellizzon of Research Diets, Inc., recently presented a webinar on the underappreciated impact of rodent diets on microbiome and gut health research, where simple husbandry decisions can profoundly affect both animal model phenotypes and experimental outcomes.

Evolving as a holobiont

Some of the most exciting recent advances in biology have been in our understanding of how the microbiome—the community of bacteria, fungi, and other single-celled microorganisms—influences host functions and behaviors.

Modern Tools and Techniques to Understand Microbes

Foreword Microbiology is one of the leading branches of modern biology and is interdisciplinary in scope as it interfaces with various basic and applied disciplines of science,

The Language of Microbial Culture: Explaining Prebiotics, Probiotics, Synbiotics and Postbiotics

It’s no secret that it’s one of my favorite subjects—the burgeoning field of human gastrointestinal microbiology. I know…it’s easy to get caught up in the comparative excitement of it all.

To see the unseen: ‘Microbiomes’ show explores the common ground between arts, science

At first glance, it may appear that scientists and artists look at the world in different ways, but look again: Careful observation is at the heart of both callings. “Microbiomes: To See the Unseen,” the latest collaboration between the arts and sciences at The Arts Center in Corvallis, takes that observation to a microscopic level:

Bill Gates and Ed Yong Talk About Microbes

Of Microbes and Men You Should Appreciate Germs By Bill Gates Find Out More: gatesnotes

Sampling Strategies for Three-Dimensional Spatial Community Structures in IBD Microbiota Research

Identifying intestinal microbiota is arguably an important task that is performed to determine the pathogenesis of inflammatory bowel diseases (IBD); thus, it is crucial to collect and analyze intestinally-associated microbiota.

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