Bacterial Metabolism Affects the C. elegans Response to Cancer Chemotherapeutics

Highlights •Bacteria differentially affect the C. elegans response to FUDR and camptothecin •Bacterial metabolism is required for the C. elegans chemotherapeutic response •Genetic screens with two bacterial species and three drugs to unravel mechanism


Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction.

Abstract Levels of inflammatory mediators in circulation are known to increase with age, but the underlying cause of this age-associated inflammation is debated.


Giardia alters commensal microbial diversity throughout the murine gut

ABSTRACT Giardia lamblia is the most frequently identified protozoan cause of intestinal infection.


Bacteria isolated from lung modulate asthma susceptibility in mice

Abstract Asthma is a chronic, non-curable, multifactorial disease with increasing incidence in industrial countries.


Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens

Abstract The high susceptibility of neonates to infections has been assumed to be due to immaturity of the immune system, but the mechanism remains unclear.


Engineered Regulatory Systems Modulate Gene Expression of Human Commensals in the Gut

Highlights •We introduce tools for modulating microbiome gene expression inside the gut •Engineered promoters couple gene expression in Bacteroides to a synthetic inducer


Urinary and Fecal Metabonomics Study of the Protective Effect of Chaihu-Shu-Gan-San on Antibiotic-Induced Gut Microbiota Dysbiosis in Rats

Abstract Accumulating evidence suggests that the gut microbiota dysbiosis and their host metabolic phenotype alteration is an important factor in human disease development.


Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease

Viruses compound dietary pathology Reoviruses commonly infect humans and mice asymptomatically. Bouziat et al. found that immune responses to two gut-infecting reoviruses take different paths in mice (see the Perspective by Verdu and Caminero).


Intestinal, extra-intestinal and systemic sequelae of Toxoplasma gondii induced acute ileitis in mice harboring a human gut microbiota

Abstract Background Within seven days following peroral high dose infection with Toxoplasma gondii susceptible conventionally colonized mice develop acute ileitis due to an underlying T helper cell (Th) -1 type immunopathology.


Caspase recruitment domain 9, microbiota, and tryptophan metabolism: dangerous liaisons in inflammatory bowel diseases

Abstract PURPOSE OF REVIEW Inflammatory bowel diseases (IBDs) develop as a result of a combination of genetic predisposition, dysbiosis of the gut microbiota, and environmental influences.


Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction

Highlights •Age-associated inflammation drives macrophage dysfunction and tissue damage •Mice under germ-free conditions are protected from age-associated inflammation •Co-housing germ-free mice with old, but not young, mice increases age-related inflammation •Age-related microbiota changes can be reversed by reducing TNF levels


Starch-enriched diet modulates the glucidic profile in the rat colonic mucosa

Abstract Purpose The protective function of the intestinal mucosa largely depends on carbohydrate moieties that as a part of glycoproteins and glycolipids form the epithelial glycocalyx or are secreted as mucins.


High-fat feeding rather than obesity drives taxonomical and functional changes in the gut microbiota in mice

Abstract Background It is well known that the microbiota of high-fat (HF) diet-induced obese mice differs from that of lean mice, but to what extent, this difference reflects the obese state or the diet is unclear.


Immune sensor maintains gut microbiome

Summary Emerging evidence indicates that the immune system can influence microbiome composition.


Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior

Abstract There is increasing concern about potential long-term effects of antibiotics on children’s health.


Raspberry pomace alters cecal microbial activity and reduces secondary bile acids in rats fed a high-fat diet

Abstract The profile of bile acids (BA) largely depends on the enzymatic activity of the microbiota, but this can be modulated by the dietary addition of biologically active compounds, e.g., polyphenols and polyunsaturated fatty acids.


Engineering bacterial thiosulfate and tetrathionate sensors for detecting gut inflammation

Abstract There is a groundswell of interest in using genetically engineered sensor bacteria to study gut microbiota pathways, and diagnose or treat associated diseases.


Cyp3a11 is not essential for the formation of murine bile acids

Abstract Humans and mice differ substantially in their bile acid profiles as mice in addition to cholic acid (CA) predominantly synthesize 6β-hydroxylated muricholic acids (MCAs) whereas humans produces chenodeoxycholic acid (CDCA) and CA as primary bile acids.


Annual Review of Genomics and Human Genetics

Abstract Over the past few years, microbiome research has dramatically reshaped our understanding of human biology.


Iron Supplements Modulate Colon Microbiota Composition and Potentiate the Protective Effects of Probiotics in Dextran Sodium Sulfate-induced Colitis

Abstract BACKGROUND: Iron is an important nutrient for both the host and colonizing bacteria.






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