Spatial organization of a model 15-member human gut microbiota established in gnotobiotic mice

Significance Spatial structure is postulated to have a powerful influence on establishing and sustaining the signaling and metabolic exchanges that define relationships among members of the gut microbiota and host.


Increased weight gain by C-section: Functional significance of the primordial microbiome

Abstract Epidemiological evidence supports a direct association between early microbiota impact—including C-section—and obesity.


A preliminary examination of gut microbiota, sleep, and cognitive flexibility in healthy older adults

Highlights •Results suggest an association between gut microbiota and cognitive flexibility. •Poor sleep precedes lower cognitive flexibility and altered microbiome composition. •Altered microbiome composition may associate poor sleep to adverse cognitive outcomes.


Gender-based differences in host behavior and gut microbiota composition in response to high fat diet and stress in a mouse model

Obesity is associated with a high prevalence of mood disorders such as anxiety and depression.


Spatial organization of a model 15-member human gut microbiota established in gnotobiotic mice

Significance Spatial structure is postulated to have a powerful influence on establishing and sustaining the signaling and metabolic exchanges that define relationships among members of the gut microbiota and host.


Interhost dispersal alters microbiome assembly and can overwhelm host innate immunity in an experimental zebrafish model

Significance Manipulating the microbial communities associated with animals to improve host health requires a comprehensive understanding of the mechanisms driving microbiome variation, which a strict focus on host-specific factors has been insufficient in providing.


Vancomycin and ceftriaxone can damage intestinal microbiota and affect the development of the intestinal tract and immune system to different degrees in neonatal mice

Abstract This study aimed to determine how antibiotic-driven intestinal dysbiosis impairs the development and differentiation of the digestive tract and immune organs of host animals.


Sleep and the gut microbiome: antibiotic-induced depletion of the gut microbiota reduces nocturnal sleep in mice

Abstract Several bacterial cell wall components such as peptidoglycan and muramyl peptide are potent inducers of mammalian slow-wave sleep when exogenously administered to freely behaving animals.


Can intestinal microbiota be associated with non-intestinal cancers?

Abstract While the role of intestinal microbiota is increasingly recognized in the etiology of digestive cancers, its effects on the development of cancer in other parts of the body have been little studied.


Ganoderma lucidum polysaccharides improve insulin sensitivity by regulating inflammatory cytokines and gut microbiota composition in mice

Highlights •Ganoderma lucidum polysaccharides (GLP) ameliorated low grade chronic inflammation. •GLP ameliorated non-esterified fatty acid outflux and ectopic lipid accumulation. •GLP improved systemic insulin sensitivity. •GLP changed the composition of gut microbiota.


Control of lupus nephritis by changes of gut microbiota

Abstract Background Systemic lupus erythematosus, characterized by persistent inflammation, is a complex autoimmune disorder with no known cure.


The gastric microbiome, its interaction with Helicobacter pylori, and its potential role in the progression to stomach cancer

Introduction Gastric adenocarcinoma is the third leading cause of cancer-related death worldwide, accounting for more than 720,000 deaths annually [1].


A study of the prebiotic-like effects of tomato juice consumption in rats with diet-induced non-alcoholic fatty liver disease (NAFLD).

Abstract Gut microbiota may play a role in the pathogenesis of NAFLD.


Decaffeinated green and black tea polyphenols decrease weight gain and alter microbiome populations and function in diet-induced obese mice

Purpose Decaffeinated green tea (GT) and black tea (BT) polyphenols inhibit weight gain in mice fed an obesogenic diet.


The microbiota influences cell death and microglial colonization in the perinatal mouse brain

Highlights •Effects of the absence of a microbiota were examined in the neonatal mouse brain. •Pro-inflammatory cytokine expression was decreased in germ-free mice. •Microbiota influenced cell death and microglial labeling a region specific manner.


Human Gut-Derived Commensal Bacteria Suppress CNS Inflammatory and Demyelinating Disease

Abstract The human gut is colonized by a large number of microorganisms (∼1013 bacteria) that support various physiologic functions.


The gut-liver axis: impact of a mouse model of small-bowel bacterial overgrowth

Abstract Background The mechanisms by which intestinal bacteria impact liver diseases remain poorly understood. The aim of this study was to develop a mouse model of small-bowel bacterial overgrowth and to determine its impact on hepatobiliary injury.


The intestinal microbiota determines the colitis-inducing potential of T-bet-deficient Th cells in mice

Abstract Conflicting evidence has been provided as to whether induction of intestinal inflammation by adoptive transfer of naïve T cells into Rag−/− mice requires expression of the transcription factor T-bet by the T cells.


Development of persistent gastrointestinal S. aureus carriage in mice

Abstract One fifth to one quarter of the human population is asymptomatically, naturally and persistently colonised by Staphylococcus aureus.


Modeling a Superorganism – Considerations Regarding the Use of “Dirty” Mice in Biomedical Research

Abstract An ever-expanding body of evidence in both humans and animal models demonstrates the influence of the resident gut microbiota on host health and disease susceptibility.






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