Commensal Microbes May Initiate and Drive Immune Responses in Lupus

Posted by: | April 24, 2018 | Comments

Commensal Microbes May Initiate and Drive Immune Responses in Lupus

Spontaneous lupus erythematosus (SLE) is a chronic autoimmune disease with an unclear cause. Nearly all lupus patients have high levels of anti-nuclear antibodies with a relatively high proportion being pathogenic anti-Ro protein antibodies. At the end of March, researchers at Yale University published a paper entitled “Commensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus” in the journal Science Translational Medicine in which the authors demonstrated that Ro60 orthologs exist in commensal bacteria commonly found in or on the human body.

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