New research explores how the tiny organisms in your gut might be influencing your immune system and lupus disease activity
With ten times as many microorganisms in the gut as cells in the entire body, recent research has shown they play a role in everything from autoimmune disease to disease susceptibility, but little is yet known about how or why. Three researchers shared exciting work into how the gut microbiome – bacteria, fungi and single-celled organisms — may influence different aspects of lupus.
The gut and the gender imbalance in lupus
Why lupus affects women 9 times more than men is often asked; Michele Kosiewicz, PhD, from the University of Louisville, is asking the opposite question — why are men less likely to develop lupus and can the answer inform new therapies.
Dr. Kosiewicz is testing whether the sex hormones that determine gender affect the type of lupus-prone bacteria in the gut. It is well known that the female hormone estrogen can exacerbate disease but Dr. Kosiewicz is investigating if male hormones which include testosterone, play a protective role in men.
Discover More: Lupus Research Alliance