Bisphenol-A alters microbiota metabolites derived from aromatic amino acids and worsens disease activity during colitis

Posted by: | June 20, 2018 | Comments

ABSTRACT

Inflammatory bowel disease is a complex collection of disorders. Microbial dysbiosis as well as exposure to toxins including xenoestrogens are thought to be risk factors for inflammatory bowel disease development and relapse. Bisphenol-A has been shown to exert estrogenic activity in the colon and alter intestinal function, but the role that xenoestrogens, such as bisphenol-A , play in colonic inflammation has been previously described but with conflicting results. We investigated the ability of bisphenol-A to exacerbate colonic inflammation and alter microbiota metabolites derived from aromatic amino acids in an acute dextran sulfate sodium-induced colitis model.

Read more at: Sage Journals

Jennifer AA DeLuca, et al. Experimental Biology and Medicine. https://doi.org/10.1177/1535370218782139. June 6, 2018.





Stay up-to-date!
Email Address *
First Name
Last Name

* indicates required
Privacy Policy




Terms & Conditions | Privacy Policy | © 2018 The Translational Microbiome Research Forum