Chitosan oligosaccharides improve the disturbance in glucose metabolism and reverse the dysbiosis of gut microbiota in diabetic mice

Posted by: | March 30, 2018 | Comments

Chitosan oligosaccharides improve the disturbance in glucose metabolism and reverse the dysbiosis of gut microbiota in diabetic mice

ABSTRACT

The aim of this study is to investigate the effect of chitosan oligosaccharides (COS) on type 2 diabetes mellitus. Wild type C57BL/6J mice or diabetic db/db mice were treated with vehicle or COS for three months. COS treatment significantly decreased the blood glucose (P < 0.01) and reversed the insulin resistance (P < 0.05) in db/db mice, which was accompanied by suppressing the inflammation mediators (P < 0.05), down-regulating the lipogenesis (P < 0.01) and inhibiting the adipocyte differentiation (P < 0.05) in white adipose tissue.

Read more at: ScienceDirect

Junping Zheng, Xubing Yuan, Gong Cheng, Siming Jiao, Cui Feng, Xiaoming Zhao, Heng Yin, Yuguang Du, Hongtao Liu. ScienceDirect. DOI: https://doi.org/10.1016/j.carbpol.2018.02.058. 21 Mar 2018.





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