Commensal Microbes Induce Serum IgA Responses that Protect against Polymicrobial Sepsis

Posted by: | February 28, 2018 | Comments

Commensal Microbes Induce Serum IgA Responses that Protect against Polymicrobial Sepsis

ABSTRACT

Serum immunoglobulin A (IgA) antibodies are readily detected in mice and people, but the mechanisms underlying the induction of serum IgA and its role in host protection remain uncertain. We report that select commensal bacteria induce several facets of systemic IgA-mediated immunity. Exposing conventional mice to a unique but natural microflora that included several members of the Proteobacteria phylum led to T cell-dependent increases in serum IgA levels and the induction of large numbers of IgA-secreting plasma cells in the bone marrow.

Read more at: Cell Host & Microbe

Joel R. Wilmore, et al. DOI: https://doi.org/10.1016/j.chom.2018.01.005. 2018.





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