Complementary intestinal mucosa and microbiota responses to caloric restriction

Posted by: | August 6, 2018 | Comments

ABSTRACT

Complementary intestinal mucosa and microbiota responses to caloric restriction

The intestine is key for nutrient absorption and for interactions between the microbiota and its host. Therefore, the intestinal response to caloric restriction (CR) is thought to be more complex than that of any other organ. Submitting mice to 25% CR during 14 days induced a polarization of duodenum mucosa cell gene expression characterised by upregulation, and downregulation of the metabolic and immune/inflammatory pathways, respectively. The HNF, PPAR, STAT, and IRF families of transcription factors, particularly the Pparα and Isgf3 genes, were identified as potentially critical players in these processes.

Read more at: Scientific Reports

Kalina Duszka, Sandrine Ellero-Simatos, Ghim Siong Ow, Marianne Defernez, Eeswari Paramalingam, Adrian Tett, Shi Ying, Jürgen König, Arjan Narbad, Vladimir A. Kuznetsov, Hervé Guillou & Walter Wahli. Scientific Reports. DOI: https://doi.org/10.1038/s41598-018-29815-7. 27 July 2018.





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