Ganoderma lucidum polysaccharides improve insulin sensitivity by regulating inflammatory cytokines and gut microbiota composition in mice

Posted by: | October 10, 2017 | Comments


•Ganoderma lucidum polysaccharides (GLP) ameliorated low grade chronic inflammation.
•GLP ameliorated non-esterified fatty acid outflux and ectopic lipid accumulation.
•GLP improved systemic insulin sensitivity.
•GLP changed the composition of gut microbiota.

Ectopic lipid accumulation and low-grade chronic inflammation are critical pathogenesis of insulin resistance development. Ganoderma lucidum is a traditional Chinese herb for balancing energy homeostasis. In this research, we determined the effects of G. lucidum polysaccharides (GLP) on high-fat diet (HFD)-induced insulin resistant mice. We observed that GLP treatment decreased plasma insulin concentration and reversed HFD-induced systemic insulin resistance. Meanwhile, GLP ameliorated low-grade chronic inflammation, inducing lipolysis in adipose tissues. GLP decreased plasma triglyceride and non-esterified fatty acid outflux by suppressing mRNA expressions of hormone-sensitive lipase, fatty acid binding protein 4, tumor necrosis factor-α, and interleukin-6 in epididymal fat. Finally, GLP treatment suppressed ectopic lipid accumulation in peripheral tissues and hepatic insulin-regulated lipogenesis. GLP also regulated composition of gut microbiota implicated in type 2 diabetes mellitus development.

Discover More at: ScienceDirect

S. Xua, Y. Doub, B. Yec, Q. Wua, Y. Wangd, M. Hud, F. Mad, X. Ronga, J. Guoa. Journal of Functional Foods. Volume 38, Part A, November 2017, Pages 545–552.

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