Gut microbes and the developing brain

Posted by: | March 20, 2017 | Comments



The discovery that commensal gut microbiota can influence host development and physiology beyond the gastrointestinal (GI) tract has triggered a paradigm shift in our conceptualization of the origin of human diseases. A growing body of preclinical research has demonstrated that gut microbiota exert a modulatory role on the development and function of brain circuits involved in motor control, emotion and cognition. These findings have lent support to the hypothesis that gut bacteria may play a role in the etiology and/or pathophysiology of human brain disorders. The current challenge is to understand the precise mechanisms mediating the communication between the microbiota and the brain. In the present thesis, we used a combination of mouse models (e.g., germ-free; GF, antibiotic treated, and transgenic mice), molecular, biochemical, and behavioral approaches to gain a deeper insight into the role of gut microbiota on brain development and behavior. A major goal was to explore whether microbial products from the commensal gut microbiota can be translocated into the developing brain and be sensed by pattern recognition receptors (PRRs) of the innate immune system.

Read more at: DART-Europe E-Thesis Portal

I. Arentsen T, Raith H, Qian Y, Forssberg H, Diaz Heijtz R. Host microbiota modulates development of social preference in mice. Microbial Ecology in Health & Disease, 2015, volume 26: 29719 ::pmid::26679775. II. Arentsen T, Mina D, St. Pierre J, Foster J, Forssberg H, Diaz Heijtz R. Perturbation of maternal gut microbiota during pregnancy influences offspring brain development and behavior. [Submitted]. III. Arentsen T, Qian Y, Gkotzis S, Femenia T, Wang T, Udekwu K, Forssberg H, Diaz Heijtz R. The bacterial peptidoglycan-sensing molecule Pglyrp2 modulates brain development and behavior. Molecular Psychiatry (2017) 22, 257–266; ::doi::10.1038/mp.2016.182 ::pmid::27843150. IV. Arentsen T, Khalid R, Qian Y, Diaz Heijtz R. Sex-dependent alterations in motor and anxiety-like behavior of aged bacterial peptidoglycan sensing molecule 2 knockout mice. [Submitted]

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