Gut Microbiota Modifies Olfactory-Guided Microbial Preferences and Foraging Decisions in Drosophila

Posted by: | August 7, 2017 | Comments

60H0N0Z050TRRQNRHQNRLQVRHQ9RZQUR40VRYKDQ60DQ3K3QU0K090JRMQS020K060FRSQOR0QTRSQS0P03RSQ9RYK

Highlights
•Drosophila display microbe-seeking behaviors as both larvae and adults
•These microbial preferences are shaped by host-microbe association
•Foraging decisions involve balancing cues from both microbes and nutrients

Summary
The gut microbiota affects a wide spectrum of host physiological traits, including development [ 1–5 ], germline [ 6 ], immunity [ 7–9 ], nutrition [ 4, 10, 11 ], and longevity [ 12, 13 ]. Association with microbes also influences fitness-related behaviors such as mating [ 14 ] and social interactions [ 15, 16 ]. Although the gut microbiota is evidently important for host wellbeing, how hosts become associated with particular assemblages of microbes from the environment remains unclear. Here, we present evidence that the gut microbiota can modify microbial and nutritional preferences of Drosophila melanogaster. By experimentally manipulating the gut microbiota of flies subjected to behavioral and chemosensory assays, we found that fly-microbe attractions are shaped by the identity of the host microbiota. Conventional flies exhibit preference for their associated Lactobacillus, a behavior also present in axenic flies as adults and marginally as larvae. By contrast, fly preference for Acetobacter is primed by early-life exposure and can override the innate preference. These microbial preferences are largely olfactory guided and have profound impact on host foraging, as flies continuously trade off between acquiring beneficial microbes and balancing nutrients from food. Our study shows a role of animal microbiota in shaping host fitness-related behavior through their chemosensory responses, opening a research theme on the interrelationships between the microbiota, host sensory perception, and behavior.

Read More Here: Current Biology

Adam Chun-Nin Wong, Qiao-Ping Wang, Juliano Morimoto, Alistair M. Senior, Mathieu Lihoreau, G. Gregory Neely, Stephen J. Simpson, Fleur Ponton. Publication stage: In Press Corrected Proof. DOI: http://dx.doi.org/10.1016/j.cub.2017.07.02.





Stay up-to-date!
Email Address *
First Name
Last Name

* indicates required
Keep up with the Translational Microbiome Research Forum on the following social networking sites:




Terms & Conditions | Privacy Policy | © 2016 The Translational Microbiome Research Forum