Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins

Posted by: | August 3, 2018 | Comments

ABSTRACT

Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins

High-fat (HF) diets are thought to disrupt the profile of the gut microbiota in a manner that may contribute to the neuroinflammation and neurobehavioral changes observed in obesity. Accordingly, we hypothesize that by preventing HF-diet induced dysbiosis it is possible to prevent neuroinflammation and the consequent neurological disorders. Anthocyanins are flavonoids found in berries that exhibit anti-neuroinflammatory properties in the context of obesity. Here, we demonstrate that the blackberry anthocyanin-rich extract (BE) can modulate gut microbiota composition and counteract some of the features of HF-diet induced dysbiosis. In addition, we show that the modifications in gut microbial environment are partially linked with the anti-neuroinflammatory properties of BE.

Read more at: Scientific Reports

Cláudia Marques, Iva Fernandes, Manuela Meireles, Ana Faria, Jeremy P. E. Spencer, Nuno Mateus & Conceição Calhau. Scientific Reports. DOI: https://doi.org/10.1038/s41598-018-29744-5. 27 July 2018.





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