Heterogeneity of the gut microbiome in mice: guidelines for optimizing experimental design

Posted by: | December 18, 2017 | Comments

ABSTRACT

Targeted manipulation of the gut flora is increasingly being recognized as a means to improve human health. Yet, the temporal dynamics and intra- and interindividual heterogeneity of the microbiome represent experimental limitations, especially in human cross-sectional studies. Therefore, rodent models represent an invaluable tool to study the host–microbiota interface. Progress in technical and computational tools to investigate the composition and function of the microbiome has opened a new era of research and we gradually begin to understand the parameters that influence variation of host-associated microbial communities. To isolate true effects from confounding factors, it is essential to include such parameters in model intervention studies.

Read more at: Oxford Academic

Debby Laukens, Brigitta M. Brinkman, Jeroen Raes, Martine De Vos, Peter Vandenabeele; Heterogeneity of the gut microbiome in mice: guidelines for optimizing experimental design, FEMS Microbiology Reviews, Volume 40, Issue 1, 1 January 2016, Pages 117–132, https://doi.org/10.1093/femsre/fuv036.





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