High Dose Vitamin D supplementation alters faecal microbiome and predisposes mice to more severe colitis

Posted by: | August 9, 2018 | Comments

ABSTRACT

High Dose Vitamin D supplementation alters faecal microbiome and predisposes mice to more severe colitis

Vitamin D has been suggested as a possible adjunctive treatment to ameliorate disease severity in human inflammatory bowel disease. In this study, the effects of diets containing high (D++, 10,000 IU/kg), moderate (D+, 2,280 IU/kg) or no vitamin D (D−) on the severity of dextran sodium sulphate (DSS) colitis in female C57Bl/6 mice were investigated. The group on high dose vitamin D (D++) developed the most severe colitis as measured by blinded endoscopic (p < 0.001) and histologic (p < 0.05) assessment, weight loss (p < 0.001), drop in serum albumin (p = 0.05) and increased expression of colonic TNF-α (p < 0.05).

Read more at: Scientific Reports

Simon Ghaly, Nadeem O. Kaakoush, Frances Lloyd, Terence McGonigle, Danny Mok, Angela Baird, Borut Klopcic, Lavinia Gordon, Shelley Gorman, Cynthia Forest, Roger Bouillon, Ian C. Lawrance & Prue H. Hart. Scientific Reports. DOI: https://doi.org/10.1038/s41598-018-29759-y. 31 July 2018.





Stay up-to-date!
Email Address *
First Name
Last Name

* indicates required
Privacy Policy




Terms & Conditions | Privacy Policy | © 2018 The Translational Microbiome Research Forum