Human milk oligosaccharides protect against the development of autoimmune diabetes in NOD-mice

Posted by: | March 7, 2018 | Comments

Human milk oligosaccharides protect against the development of autoimmune diabetes in NOD-mice

ABSTRACT

Development of Type 1 diabetes (T1D) is influenced by non-genetic factors, such as optimal microbiome development during early life that “programs” the immune system. Exclusive and prolonged breastfeeding is an independent protective factor against the development of T1D, likely via bioactive components. Human Milk Oligosaccharides (HMOS) are microbiota modulators, known to regulate immune responses directly. Here we show that early life provision (only for a period of six weeks) of 1% authentic HMOS (consisting of both long-chain, as well as short-chain structures), delayed and suppressed T1D development in non-obese diabetic mice and reduced development of severe pancreatic insulitis in later life.

Read more at: Scientific Reports

Ling Xiao, Belinda van’t Land, Phillip A. Engen, Ankur Naqib, Stefan J. Green, Angie Nato, Thea Leusink-Muis, Johan Garssen, Ali Keshavarzian, Bernd Stahl & Gert Folkerts. DOI: 10.1038/s41598-018-22052-y. 1 March 2018.





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