Influence of gemcitabine chemotherapy on the microbiota of pancreatic cancer xenografted mice

Posted by: | March 2, 2018 | Comments

ABSTRACT

Background and aims

Pancreatic ductal adenocarcinoma (PDAC) represents the fourth cause of cancer-related death. We aimed to evaluate whether gemcitabine treatment shapes the gut microbiota in a model of PDAC xenografted mice.
Materials and methods

Materials and methods

Pancreatic cancer xenograft mice were subjected to gemcitabine injection once per week for 3 weeks to assess the tumor volume as compared to control mice injected with normal saline solution. The composition of fecal microbiota, the activation of NF-kB pathway in cancer tissues and the serum metabolomics were further analyzed.

Read more at: SpringerLink

Concetta Panebianco, Kaarel Adamberg, Madis Jaagura, Massimiliano Copetti, Andrea Fontana, Signe Adamberg, Kaia Kolk, Raivo Vilu, Angelo Andriulli, Valerio Pazienza. DOI: https://doi.org/10.1007/s00280-018-3549-0. 22 February 2018.





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