Intergenerational transfer of antibiotic-perturbed microbiota enhances colitis in susceptible mice

Posted by: | December 4, 2017 | Comments

ABSTRACT

Antibiotic exposure in children has been associated with the risk of inflammatory bowel disease (IBD). Antibiotic use in children or in their pregnant mother can affect how the intestinal microbiome develops, so we asked whether the transfer of an antibiotic-perturbed microbiota from mothers to their children could affect their risk of developing IBD. Here we demonstrate that germ-free adult pregnant mice inoculated with a gut microbial community shaped by antibiotic exposure transmitted their perturbed microbiota to their offspring with high fidelity. Without any direct or continued exposure to antibiotics, this dysbiotic microbiota in the offspring remained distinct from controls for at least 21 weeks.

Read more at: Nature Microbiology

Anjelique F. Schulfer, Thomas Battaglia, Yelina Alvarez, Luc Bijnens, Victoria E. Ruiz, Melody Ho, Serina Robinson, Tonya Ward, Laura M. Cox, Arlin B. Rogers, Dan Knights, R. Balfour Sartor & Martin J. Blaser. (2017), Nature Microbiology. doi:10.1038/s41564-017-0075-5.





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