Microbial Changes and Host Response in F344 Rat Colon Depending on Sex and Age Following a High-Fat Diet

Posted by: | October 15, 2018 | Comments

Calorie intake (A) and changes in body weight (B) during the 8-week feeding of control or high-fat diet (6-week-old rats, n = 6; 2-year-old male rats, n = 4; 2-year-old female rats, n = 5).

Gut microbiota, an important component that affects host health, change rapidly and directly in response to altered diet composition. Recently, the role of diet–microbiome interaction on the development of colon cancer has been the focus of interest. Colon cancer occurs more frequently in an aged population, and in males. However, the effect of dietary changes on the gut microbiome has been studied mainly in young males, even though it may vary with age and sex. The aim of this study was to investigate microbial changes and host response in the colons of male and female 6-week-old (young) and 2-year-old (old) Fisher-344 rats exposed to a high-fat diet (HFD). Our results showed that exposure to HFD for 8 weeks decreased the species richness of microbiota (Chao1) and increased Firmicutes/Bacteroidetes ratio only in aged rats, and not in young rats.

Read more at: Frontiers

Sun Min Lee, Nayoung Kim, Hyuk Yoon, Ryoung Hee Nam and Dong He Lee. Frontiers in Microbiology. DOI: https://doi.org/10.3389/fmicb.2018.02236. 24 September 2018.

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