Prolonged restraint stressor exposure in outbred CD-1 mice impacts microbiota, colonic inflammation, and short chain fatty acids

Posted by: | May 11, 2018 | Comments

ABSTRACT

Prolonged restraint stressor exposure in outbred CD-1 mice impacts microbiota, colonic inflammation, and short chain fatty acids

Stressor-exposure has been shown to exacerbate inflammation and change the composition of the gastrointestinal microbiota; however stressor-induced effects on microbiota-derived metabolites and their receptors are unknown. Thus, bacterial-produced short chain fatty acids (SCFAs), as well as microbial community composition, were assessed in the colons of mice exposed to stress during infection with Citrobacter rodentium. Mice were exposed to overnight restraint on 7 consecutive nights, or left undisturbed as a control. After the first exposure of restraint, mice were orally challenged with C. rodentium or with vehicle.

Read more at: PLoS One

Ross M. Maltz, Jeremy Keirsey, Sandra C. Kim, Amy R. Mackos, Raad Z. Gharaibeh, Cathy C. Moore, Jinyu Xu, Vasudevan Bakthavatchalu, Arpad Somogyi, and Michael T. Bailey. PLoS One. DOI: https://doi.org/10.1371/journal.pone.0196961. 09 May 2018.





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