Pumpkin polysaccharide modifies the gut microbiota during alleviation of type 2 diabetes in rats

Posted by: | May 2, 2018 | Comments

ABSTRACT

Pumpkin polysaccharide is able to alleviate diabetes, but understanding of the underlining mechanism is still limited. In this study, we hypothesized that the alleviating effects of pumpkin polysaccharide is modulated via changes in the gut microbiota and short-chain fatty acid (SCFA) production in type 2 diabetic rats. After the type 2 diabetic model successfully was established, three groups of high-fat diet induced diabetic rats were intragastrically administered pumpkin polysaccharide, metformin, or saline solution respectively.

Read more at: ScienceDirect

Guimei Liu, Li Liang, Guoyong Yu, Quanhong Li. International Journal of Biological Macromolecules. DOI: https://doi.org/10.1016/j.ijbiomac.2018.04.127. 24 April 2018.





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