Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids

Posted by: | April 16, 2018 | Comments

Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids

ABSTRACT

The gut microbiota play important roles in lipid metabolism and absorption. However, the contribution of the small bowel microbiota of mammals to these diet-microbe interactions remains unclear. We determine that germ-free (GF) mice are resistant to diet-induced obesity and malabsorb fat with specifically impaired lipid digestion and absorption within the small intestine. Small bowel microbes are essential for host adaptation to dietary lipid changes by regulating gut epithelial processes involved in their digestion and absorption.

Read more at: Cell Host & Microbe

Kristina Martinez-Guryn, Nathaniel Hubert, Katya Frazier, Saskia Urlass, Mark W. Musch, Patricia Ojeda, Joseph F. Pierre, Jun Miyoshi, Timothy J. Sontag, Candace M. Cham, Catherine A. Reardon, Vanessa Leone, Eugene B. Chang. Cell Host & Microbe. DOI: https://doi.org/10.1016/j.chom.2018.03.011. April 2018.





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