Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells

Posted by: | October 3, 2018 | Comments

SUMMARY

Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells

From an organismal perspective, cancer cell populations can be considered analogous to parasites that compete with the host for essential systemic resources such as glucose. Here, we employed leukemia models and human leukemia samples to document a form of adaptive homeostasis, where malignant cells alter systemic physiology through impairment of both host insulin sensitivity and insulin secretion to provide tumors with increased glucose. Mechanistically, tumor cells induce high-level production of IGFBP1 from adipose tissue to mediate insulin sensitivity. Further, leukemia-induced gut dysbiosis, serotonin loss, and incretin inactivation combine to suppress insulin secretion.

Read more at: ScienceDirect

Haobin Ye, Biniam Adane, Nabilah Khan, Erica Alexeev, Nichole Nusbacher, Mohammad Minhajuddin, Brett M. Stevens, Amanda C. Winters, Xi Lin, John M.Ashton, Enkhtsetseg Purev, Lianping Xing, Daniel A.Pollyea, Catherine A.Lozupone, Natalie J.Serkova, Sean P.Colgan, Craig T.Jordan. Cell Press. DOI: https://doi.org/10.1016/j.ccell.2018.08.016. 27 September 2018.





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