Targeting the gut microbiome to treat the osteoarthritis of obesity

Posted by: | April 26, 2018 | Comments

ABSTRACT

Oligofructose converts the obese gut microbiome to a lean diversity profile

Obesity is a risk factor for osteoarthritis (OA), the greatest cause of disability in the US. The impact of obesity on OA is driven by systemic inflammation, and increased systemic inflammation is now understood to be caused by gut microbiome dysbiosis. Oligofructose, a nondigestible prebiotic fiber, can restore a lean gut microbial community profile in the context of obesity, suggesting a potentially novel approach to treat the OA of obesity. Here, we report that — compared with the lean murine gut — obesity is associated with loss of beneficial Bifidobacteria, while key proinflammatory species gain in abundance.

Read more at: JCI Insight






Stay up-to-date!
Email Address *
First Name
Last Name

* indicates required




Terms & Conditions | Privacy Policy | © 2018 The Translational Microbiome Research Forum