The enteric microbiota regulates jejunal Paneth cell number and function without impacting intestinal stem cells

Posted by: | June 22, 2018 | Comments

ABSTRACT

Paneth cells (PCs) are epithelial cells found in the small intestine, next to intestinal stem cells (ISCs) at the base of the crypts. PCs secrete antimicrobial peptides (AMPs) that regulate the commensal gut microbiota. In contrast, little is known regarding how the enteric microbiota reciprocally influences PC function. In this study, we sought to characterize the impact of the enteric microbiota on PC biology in the mouse small intestine. This was done by first enumerating jejunal PCs in germ-free (GF) versus conventionally-raised (CR) mice.

Read more at: Taylor & Francis Online

Alexi A. Schoenborn, et al. Gut Microbes. https://doi.org/10.1080/19490976.2018.1474321. 08 June 2018.





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