TRIM31 Deficiency Is Associated with Impaired Glucose Metabolism and Disrupted Gut Microbiota in Mice

Posted by: | March 7, 2018 | Comments

ABSTRACT

Tripartite motif-containing protein 31 (TRIM31), an E3 ubiquitin ligase of the tripartite motif family, plays an important role in the innate immune response. It can reduce the activity of the nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome. However, little information is about glucose metabolic health of TRIM31-deficient mice, and investigations about gut microbiota in TRIM31-deficient mice is limited.

Read more at: Frontiers in Physiology

Jing Cheng, Fei Xue, Meng Zhang, Cheng Cheng, Lei Qiao, Jing Ma, Wenhai Sui, Xingli Xu, Chengjiang Gao, Panpan Hao, Meng Zhang and Yun Zhang. DOI: https://doi.org/10.3389/fphys.2018.00024. 15 February 2018.





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