The Translational Microbiome Research Forum is an online resource for scientists engaged in translational microbiome research to access current, topical information and to provide a platform to exchange knowledge and ideas. We encourage you to participate by actively using the commenting system, by submitting events, and by joining our email list to receive updates when new content is posted.

  • Taconic Biosciences Launches TruBIOME™ to Create Animal Models with Custom Microbiome Profiles


    Rensselaer, NY — April 15, 2019 – Taconic Biosciences, a global leader in providing genetically engineered rodent model solutions, announces the launch of TruBIOME™, a first of its kind solution enabling the generation and maintenance of mice with custom microbiome profiles. TruBIOME™ was developed to meet the research community’s need for a microbiome solution that […]

  • The 5th Annual Arrowhead Translational Microbiome Conference


    The 5th Annual Arrowhead Translational Microbiome Conference (April 16-18 | Boston) recently announced a bonus track for their upcoming annual event, which is taking place in Boston on April 16-18. For additional details visit https://www.microbiomeconference.com/. NEW PRESENTATIONS: Ultra-high Resolution Microbiome Taxonomic Profiling Enabled by Novel High-throughput, High-resolution Assay Design Mark Driscoll, Ph.D., Co-Founder and Chief […]

  • Microbes May Take Some of the Blame for the Reproducibility Crisis

    For the past several years, science has been plagued by what some consider a reproducibility crisis—the idea that many published studies don’t yield the same results when repeated by other scientists, or sometimes even by the same scientists. Surveys and studies have suggested myriad reasons such as unreliable reagents and cell lines, selective statistics, a […]

  • 2019 FNIH Lurie Prize in Biomedical Sciences Winner Uncovered the Microbiome’s Critical Role in Immune Regulation

    NORTH BETHESDA, Md., April 3, 2019 /PRNewswire/ — The Foundation for the National Institutes of Health, Inc. (FNIH) is delighted to name Yasmine Belkaid, Ph.D., the winner of the 2019 Lurie Prize in Biomedical Sciences for blazing a trail in understanding the microbiome’s significant role in immune regulation. The human body houses trillions of microscopic […]

  • Taconic Biosciences Licenses the Wild Mouse Gut Microbiome from the National Institute of Diabetes and Digestive and Kidney Diseases


    RENSSELAER, N.Y., April 01, 2019 (GLOBE NEWSWIRE) — Taconic Biosciences, a global leader in providing genetically engineered rodent model solutions, announces it has obtained a license to the Wild Mouse gut microbiome from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health (NIH). Investigators at the […]

  • Depression and the Microbiome


    New research is regularly being published on the connection between the gut microbiome and the central nervous system (CNS) — together known as the gut-brain axis. Alterations in the composition of intestinal microbiota have also been associated with antibiotic use and the progression of infectious diseases. This Taconic Insight highlights the link between the microbiome […]

  • A review of 10 years of human microbiome research activities at the US National Institutes of Health, Fiscal Years 2007-2016


    The National Institutes of Health (NIH) is the primary federal government agency for biomedical research in the USA. NIH provides extensive support for human microbiome research with 21 of 27 NIH Institutes and Centers (ICs) currently funding this area through their extramural research programs. This analysis of the NIH extramural portfolio in human microbiome research […]

  • University of Calgary to lead pan-Canadian microbiome research core

    The microbiome has an impact on every organ in the body. It is associated with every chronic disease that affects humans. For the past few years, research has focused on cataloguing what microbes are present on and in our bodies, and connecting those microbes to specific diseases. The next step is to find out how […]

  • Overcoming Challenges in the Clinical Development of Nutrition-Related Microbiome Interventions

    Arrowhead Publishers has announced the return of their Nutrition track, sponsored by Reckitt Benckiser, to the 5th Annual Translational Microbiome Conference. This year’s nutrition track will have two complementary goals: to address the challenges faced by industry when undergoing clinical development for a microbiome-based intervention and current advances in the research, production and use of […]

  • Antidepressants affect gut microbiota and Ruminococcus flavefaciens is able to abolish their effects on depressive-like behavior


    ABSTRACT Accumulating evidence demonstrates that the gut microbiota affects brain function and behavior, including depressive behavior. Antidepressants are the main drugs used for treatment of depression. We hypothesized that antidepressant treatment could modify gut microbiota which can partially mediate their antidepressant effects. Mice were chronically treated with one of five antidepressants (fluoxetine, escitalopram, venlafaxine, duloxetine […]

  • Early life stress induces type 2 diabetes-like features in ageing mice

    ABSTRACT Early life stress is known to impair intestinal barrier through induction of intestinal hyperpermeability, low-grade inflammation and microbiota dysbiosis in young adult rodents. Interestingly, those features are also observed in metabolic disorders (obesity and type 2 diabetes) that appear with ageing. Based on the concept of Developmental Origins of Health and Diseases, our study […]

  • Gut microbiota from high-risk men who have sex with men drive immune activation in gnotobiotic mice and in vitro HIV infection


    ABSTRACT Men who have sex with men (MSM) have differences in immune activation and gut microbiome composition compared with men who have sex with women (MSW), even in the absence of HIV infection. Gut microbiome differences associated with HIV itself when controlling for MSM, as assessed by 16S rRNA sequencing, are relatively subtle. Understanding whether […]

  • Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2


    ABSTRACT Microbe-host interactions are generally homeostatic, but when dysfunctional, they can incite food sensitivities and chronic diseases. Celiac disease (CeD) is a food sensitivity characterized by a breakdown of oral tolerance to gluten proteins in genetically predisposed individuals, although the underlying mechanisms are incompletely understood. Here we show that duodenal biopsies from patients with active […]

  • Adaptive Strategies of the Candidate Probiotic E. coli Nissle in the Mammalian Gut


    SUMMARY Probiotics are living microorganisms that are increasingly used as gastrointestinal therapeutics by virtue of their innate or engineered genetic function. Unlike abiotic therapeutics, probiotics can replicate in their intended site, subjecting their genomes and therapeutic properties to natural selection. We exposed the candidate probiotic E. coli Nissle (EcN) to the mouse gastrointestinal tract over […]

  • Subchronic low-dose 2,4-D exposure changed plasma acylcarnitine levels and induced gut microbiome perturbations in mice


    ABSTRACT The gut microbiota critically confers various health benefits, whereas environmental chemicals can affect its constitution and functionality thereby increasing disease risk. In the present study, we aim to evaluate the toxic effects of a wildly-used herbicide 2,4-D (2,4-dichlorophenoxyacetic acid) on the gut microbiome and host using an occupationally relevant dose. A mouse model was […]

  • Alteration of GLP-1/GPR43 expression and gastrointestinal motility in dysbiotic mice treated with vancomycin


    ABSTRACT Gut microbiota plays a pivotal role in various aspects of host physiology, including metabolism, gastrointestinal (GI) motility and hormonal secretion. In the present study, we investigated the effect of antibiotic-associated dysbiosis on metabolism and GI motility in relation to colonic expression of glucagon-like peptide-1 (GLP-1) and G protein coupled receptor (GPR)43. Specific pathogen-free (SPF) […]

  • Potential Functions of the Gastrointestinal Microbiome Inhabiting the Length of the Rat Digest Tract


    ABSTRACT The rat is an important model animal used frequently in biological researches exploring the correlations between gut microbiome and a wide array of diseases. In this study, we used an extended ancestral-state reconstruction algorithm to predict the functional capabilities of the rat gastrointestinal microbiome. Our results indicate an apparent tendency toward metabolic heterogeneity along […]

  • Supplementation of dietary non-digestible oligosaccharides from birth onwards improve social and reduce anxiety-like behaviour in male BALB/c mice


    ABSTRACT Objective: The intestinal microbiota is acknowledged to be essential in brain development and behaviour. Their composition can be modulated by prebiotics such as short-chain galacto-oligosaccharides (scGOS) and long-chain fructo-oligosaccharide (lcFOS). Several studies reported potential health benefit of prebiotics on behaviour. As the prebiotic mixture of scGOS and lcFOS is included in infant formula, we […]

  • Events
    We maintain a calendar of events and meetings related to the field of Microbiome Research. Check it often for new events and conferences, or submit something for the calendar here.

  • Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice


    Significance Studies using experimental models have indicated that multiple sclerosis (MS)-like disease can be triggered in the gut following interactions of brain autoimmune T lymphocytes with local microbiota.

  • BOOK REVIEW: GNOTOBIOTICS


    Gnotobiotics, edited by Trenton Schoeb and Kathryn Eaton, is invaluable to those developing or managing gnotobiotic facilities.

  • Stress could be just as unhealthy as junk food


    Brigham Young University: We all know that a poor diet is unhealthy, but a new BYU study finds that stress may just as harmful to our bodies as a really bad diet.

  • Infection via mosquito bite alters Zika virus replication kinetics in rhesus macaques


    Abstract For more than three decades it has been recognized that small amounts of vector saliva can significantly alter the infectivity of vector-borne pathogens and subsequent in vivo dynamics.

  • Of Mice, Dirty Mice, and Men: Using Mice To Understand Human Immunology


    Abstract Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans.

  • Microbial Genetic Composition Tunes Host Longevity


    Highlights •Systematic analysis of longevity-promoting microbial genetic variations •Colanic acid as a pro-longevity natural compound effective in different species

  • Learning more about the gut microbiota


    The GMFH editing team recommends these book selections on the topic.

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