Does the Microbiome Affect Immunotherapy Outcomes?

The microbiome consists of about 100 trillion microbes (microbiota) and their genomes. These are made of bacteriophage, fungi, bacteria, protozoa (single-cell eukaryotes), and viruses in the human body. They play an important role in health maintenance systems of the immune system, as well as in drugs and foreign substances (xenobiotics) metabolism. Researchers have discovered that […]


Weight Gain Could Be Linked To Gut Bacteria

UT Southwestern researchers have found a key driver of the crosstalk that helps synchronize the absorption of nutrients in the gut with the rhythms of the Earth’s day-night light cycle. Their findings could have far-ranging implications for obesity in affluent countries and malnutrition in impoverished countries. In the study, Dr. Lora Hooper and her research […]


A mouse’s metabolism may follow circadian rhythms set by gut bacteria

Mice (and maybe people) may metabolize food according to daily, circadian rhythms set by gut bacteria. Microbes in the small intestine of mice rhythmically dictate when fat is taken up by cells that line the organ, researchers report. The study, described in the Sept. 27 Science, details how gut microbes influence a host’s metabolism. If […]


Microbe Helps Hosts Exercise Longer

A recent study published in Nature Medicine reports on the correlation between rigorous exercise and the increase in abundance of a specific bacterial genus in the human gut microbiome. The collaborative group, which includes CRISPR-researcher George Church from Harvard Medical School, established a connection between the abundance of Veillonella atypica and an increased ability to […]


On-Demand Webinar: Ensure Reproducible Microbiome Profiles in In Vivo Research

Taconic Biosciences’ Marina Hanson DVM, PhD presents this exclusive webinar where she describes how TruBIOME™ enables the generation and maintenance of mice with defined custom microbiome profiles, including insight into the Wild Mouse gut microbiota. Watch today to learn: About the Wild Mouse gut microbiome and how it varies from the microbiota of standard laboratory […]


Microbial chemistry gains fresh focus

The tools of chemical biology, genomics and data mining can yield insights into the metabolites of the microbiome. Studies of the microorganisms that live on and inside animals’ bodies have long relied on DNA sequencing, which can reveal which species abound and how these microbial communities respond to their environment. Now, the analytical methods of […]


The Next Ten Years of Microbiome Research

The Human Microbiome Project’s former Program Coordinator, Lita Proctor, set out priorities for the next ten years of human microbiome research in a wide-ranging article for Nature. She also provides reflections on the completed Human Microbiome Project that helped jump-start microbiome research in the US and beyond. In the past ten years microbiome research has […]


Taconic Biosciences Participates in Second Rodent Research Reference Mission to the International Space Station

Resulting Studies Will Provide Critical Reference Data to Drive Advancements in Human Health Rensselaer, NY — September 3, 2019 – Taconic Biosciences, a global leader in providing genetically engineered animal model solutions, announces its participation in the second Rodent Research Reference (RRR) mission to the International Space Station. Taconic has a history with NASA dating […]


The Microbiomics Standards & Controls Initiative

What is M-SCI? The Microbiomics Standards & Controls Initiative Receive free standards and controls. Improve accuracy and data reproducibility. Help the field of Microbiomics incorporate controls and standards in every experiment. Why Give Away Free Standards & Controls? Availability is Key to Standardization Leaders in the field of microbiomics have recognized that the lack of […]


Antimicrobial resistance and the microbiome

Microbiome, Environmental Microbiome and Animal Microbiome are coming together to launch a special series inviting authors to submit their research pertaining to antimicrobial resistance (AMR) and the microbiome. The emergence and spread of AMR can only be described as a catastrophic problem for human and animal health. It is projected that there would be more […]


IBD Severity and Fungi in Microbiome

The microbiome includes not just bacteria, but also fungi, viruses and parasites. While most of the attention has been on bacterial components of the microbiome, new research links a commensal yeast found on human skin to disease severity in inflammatory bowel disease (IBD). Linking Common Fungi with IBD Severity In a new paper published in […]


Remodeling unhealthful gut microbiomes to fight disease

You are what you eat — right down to the microbiome living in your gut. Diet can affect which microbes are in the intestinal tract, and research has shown that harmful gut microbiome changes can lead to illnesses such as heart disease, obesity and cancer. Today, scientists will report the development of molecules that can […]


Nanoparticle relieved symptoms of inflammatory bowel disease in mice

ANN ARBOR—Researchers at the University of Michigan College of Pharmacy have developed a nanoparticle that alters the gut microbiome and alleviates symptoms of inflammatory bowel disease in mice more effectively than common FDA-approved medications. The gut microbiome––the body’s environment of healthy and unhealthy bacteria––is the next frontier for drug development, and an imbalanced gut microbiome […]


FDA Issues Safety Alert on Investigational Use of Fecal Microbiota Transplantation

Fecal microbiota transplantation (FMT) is the transfer of fecal matter from a healthy individual into a recipient with the goal of treating an ailment. In its simplest form FMT has been used to treat disease with reports detailing its use as far back as 1700 years ago in China1. Modern applications of this procedure have […]


New Mouse Model Predicts Two Clinical Trial Failures in Humans

A new mouse model designed with a microbiome similar to that of wild mice may be a better predictor of human responses to some drugs than commonly used lab mice, according to a study published today in Science. The authors repeated two preclinical studies that had demonstrated positive results in mice only to fail when […]


Using a more diverse microbiome, scientists look to create a better lab mouse

Lab mice are notoriously clean: To prevent introducing anything that could disrupt results, researchers house them in sterile conditions, and the food and water they ingest are monitored for extreme quality. This also means that the mice’s microbiomes — the cohort of microorganisms that reside within all animals and influence many body processes — have […]


Microbiomes of Lab Mice Take a Walk on the Wild Side

National Institutes of Health scientists have developed a new mouse model that could help to improve the relevance of these invaluable laboratory test animals to human health and disease, and the development of human therapeutics. The new mice, which the researchers have called “wildlings”, have acquired the microbiomes of wild mice, but retain the genetics […]


Bone and the Microbiome Have a Brittle Relationship

Laura McCabe had been living a dual professional life at Michigan State University for more than a decade, studying bone in her lab while teaching medical students gastrointestinal physiology in the classroom, when she came across a call for proposals from the Crohn’s and Colitis Foundation. Could researchers look into how inflammatory bowel diseases affect […]


World Microbiome Day 2019

World Microbiome Day is on June 27th this year. World Microbiome Day began in 2018 to demonstrate its emergence as a subject with global impact. That impact is being felt across a variety of disciplines including science, medicine, and nutrition. This year’s theme is “Bacterial Resistance to Antibiotics” highlighting the need to better understand microbes. […]


Gut Microbe Takes a Share of Our Brain Meds

Swallowing a drug can tilt the gut-brain axis, alleviating the symptoms of neurodegenerative diseases such as Parkinson’s. Yet the axis can resist tilting as though its orientation were maintained by hidden sources of inertia. Suspected inertial dampeners include gut microbes. Although gut microbes have been thought to metabolize and lessen the efficacy of levodopa, the […]






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