New Mouse Model Predicts Two Clinical Trial Failures in Humans

A new mouse model designed with a microbiome similar to that of wild mice may be a better predictor of human responses to some drugs than commonly used lab mice, according to a study published today in Science. The authors repeated two preclinical studies that had demonstrated positive results in mice only to fail when […]


Using a more diverse microbiome, scientists look to create a better lab mouse

Lab mice are notoriously clean: To prevent introducing anything that could disrupt results, researchers house them in sterile conditions, and the food and water they ingest are monitored for extreme quality. This also means that the mice’s microbiomes — the cohort of microorganisms that reside within all animals and influence many body processes — have […]


Microbiomes of Lab Mice Take a Walk on the Wild Side

National Institutes of Health scientists have developed a new mouse model that could help to improve the relevance of these invaluable laboratory test animals to human health and disease, and the development of human therapeutics. The new mice, which the researchers have called “wildlings”, have acquired the microbiomes of wild mice, but retain the genetics […]


Bone and the Microbiome Have a Brittle Relationship

Laura McCabe had been living a dual professional life at Michigan State University for more than a decade, studying bone in her lab while teaching medical students gastrointestinal physiology in the classroom, when she came across a call for proposals from the Crohn’s and Colitis Foundation. Could researchers look into how inflammatory bowel diseases affect […]


World Microbiome Day 2019

World Microbiome Day is on June 27th this year. World Microbiome Day began in 2018 to demonstrate its emergence as a subject with global impact. That impact is being felt across a variety of disciplines including science, medicine, and nutrition. This year’s theme is “Bacterial Resistance to Antibiotics” highlighting the need to better understand microbes. […]


Gut Microbe Takes a Share of Our Brain Meds

Swallowing a drug can tilt the gut-brain axis, alleviating the symptoms of neurodegenerative diseases such as Parkinson’s. Yet the axis can resist tilting as though its orientation were maintained by hidden sources of inertia. Suspected inertial dampeners include gut microbes. Although gut microbes have been thought to metabolize and lessen the efficacy of levodopa, the […]


Language, numeracy and logic in microbiome science

To deliver precision therapeutics, microbiome-based medicine will require precision of language, logic and numerical accuracy. Epidemiological lessons of the past suggest that attempts to link almost everything in modern life with the microbiome as a risk factor for disease, without rapprochement with plausible mechanisms, will generate controversy rather than consensus. Read more at Nature Reviews: […]


USF Health convenes first Microbiome Joint Workshop with University of Florida

The University of South Florida and the University of Florida convened a Microbiome Joint Workshop at USF Health on May 28, with research presentations by basic scientists and clinician scientists from both universities. It was an important first step in working together to unravel how different microorganisms living in our guts, on our skin, and […]


EU biotech firms unite in pushing for ‘harmonised’ microbiome therapeutics regulation

The Intestinal Microbiome-based Medicines European Task Group (IMM-ETG) involves Caelus Health, EnteroBiotix, Ferring Pharmaceuticals and Maat Pharma along with Pharmabiotic Research Institute (PRI). “The IMM-ETG has been established to contribute to a harmonised regulatory framework in Europe for the intestinal microbiome products based on the whole ecosystem,” said Dr. Luc Sterkman, CEO of Caelus Health. […]


Priorities for the next 10 years of human microbiome research

Over the past decade, more than US$1.7 billion has been spent on human microbiome research. Major projects are under way in the United States, the European Union, China, Canada, Ireland, South Korea and Japan. This investment has confirmed the importance of the microbiome to human health and development. It is now known, for instance, that […]


The Human Microbiome Project expands the toolbox for studying host and microbiome interactions

Results from three long-term studies following host and microbiome characteristics during pregnancy and preterm birth, inflammatory bowel disease, and prediabetes have expanded our understanding of how humans and microbes interact and the resulting consequences for our health. The studies were funded as part of a second phase of the National Institutes of Health’s Human Microbiome […]


Transportation Affects Gut Microbiome of Laboratory Mice

Experimental controls are at the center of every quality experiment, and understanding the causes of microbiome variability is key to controlling for microbiome-related effects. Researchers that utilize murine models attempt to control for possible microbiome variability by ordering mice from the same vendor, using littermate controls, and employing co-housing strategies1. Given the ongoing research reproducibility […]


Cell Press: Cell Host & Microbe

The Human Microbiome has been a recent area of intense research, rapid progress, and exciting advances. Cell Host & Microbe has published a diverse array of exciting articles related to The Human Microbiome. In this Collection, we present a selection of recent research and review articles on the topic. Read more at Cell Press: Cell […]


How Antibiotics Affect Your Microbiome

The human gut microbiome is a complex, highly-evolved commensal community with an integral role in your response to disease and how well you maintain homeostasis. While commensal bacteria vary from person to person, a person’s specific microbiome should contain the same relative percentage of bacterial species over their lifespan. The balance of this community can […]


Do you know what’s in your water?

Most researchers know the pain of trying and failing to replicate a published experiment. This can result from something as simple as a poorly written methods section, in which important experimental details have been omitted. Barnett and Gibson recently called out the importance of an in vivo experimental detail that is commonly left out and […]


Taconic Biosciences Launches TruBIOME™ to Create Animal Models with Custom Microbiome Profiles

Rensselaer, NY — April 15, 2019 – Taconic Biosciences, a global leader in providing genetically engineered rodent model solutions, announces the launch of TruBIOME™, a first of its kind solution enabling the generation and maintenance of mice with custom microbiome profiles. TruBIOME™ was developed to meet the research community’s need for a microbiome solution that […]


The 5th Annual Arrowhead Translational Microbiome Conference

The 5th Annual Arrowhead Translational Microbiome Conference (April 16-18 | Boston) recently announced a bonus track for their upcoming annual event, which is taking place in Boston on April 16-18. For additional details visit https://www.microbiomeconference.com/. NEW PRESENTATIONS: Ultra-high Resolution Microbiome Taxonomic Profiling Enabled by Novel High-throughput, High-resolution Assay Design Mark Driscoll, Ph.D., Co-Founder and Chief […]


Microbes May Take Some of the Blame for the Reproducibility Crisis

For the past several years, science has been plagued by what some consider a reproducibility crisis—the idea that many published studies don’t yield the same results when repeated by other scientists, or sometimes even by the same scientists. Surveys and studies have suggested myriad reasons such as unreliable reagents and cell lines, selective statistics, a […]


2019 FNIH Lurie Prize in Biomedical Sciences Winner Uncovered the Microbiome’s Critical Role in Immune Regulation

NORTH BETHESDA, Md., April 3, 2019 /PRNewswire/ — The Foundation for the National Institutes of Health, Inc. (FNIH) is delighted to name Yasmine Belkaid, Ph.D., the winner of the 2019 Lurie Prize in Biomedical Sciences for blazing a trail in understanding the microbiome’s significant role in immune regulation. The human body houses trillions of microscopic […]


Taconic Biosciences Licenses the Wild Mouse Gut Microbiome from the National Institute of Diabetes and Digestive and Kidney Diseases

RENSSELAER, N.Y., April 01, 2019 (GLOBE NEWSWIRE) — Taconic Biosciences, a global leader in providing genetically engineered rodent model solutions, announces it has obtained a license to the Wild Mouse gut microbiome from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health (NIH). Investigators at the […]






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