Impact of the gut microbiota on rodent models of human disease

Posted by: | January 6, 2024 | Comments

New “Topic Highlight” paper published in World Journal of Gastroenterology in December 2014 reviews the influence of the gut microbiota on rodent disease models, and presents several proposed underlying mechanisms for this effect.
The authors state that animal breeders and researchers need to be more aware of this so-called gut microbiota effect, and that it is necessary to develop methods to control it.

This is an important branch of translational microbiome research that stretches further than the dedicated studies for understanding different microbiomes’ significance in various modeled diseases. We also need to understand that the baseline microbiome may be very important in studies that are not currently adressing the gut microbiota. The authors propose that information about the baseline microbiota may be incorporated in the data evaluation, or that the animals are provided with a defined microbiota which supports the development of the desired disease phenotype in the model.

Read more at: World Journal of Gastroenterology

Hansen AK, Friis Hansen CH, Krych L, Nielsen DS. World J Gastroenterol. 2014 Dec 21;20(47):17727-17736.
Impact of the gut microbiota on rodent models of human disease.

  • Matthew Ricci

    I completely agree and would like to point out the importance of the diet (especially the fiber type and level) that is fed to the animals before and during studies. This will definitely have a large impact on gut health and microbial populations which of course can then impact the study. Diet unfortunately is often a forgotten environmental variable which is easily controlled with the proper approach.

    • Jim Vitale

      Matthew, Great point. Food can be a controlled variable. Other enviromental variables include bedding type and water source including any treatment to sterilze. Food, bedding and water can all be controlled to some extent. By controlling, we may find that we remove some of the variances we see from study to study. I’m sure we will see more publications coming out on this subject in the coming months.

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