Posted by: | October 28, 2023 | Comments

Excluded Flora Standard Allows for Models Free of Two Additional Commensal Organisms

HUDSON, NY Oct 20, 2023 - Taconic Biosciences today announced that it has added the Excluded Flora (EF) standard to the set of precisely defined health standards applied to its production of laboratory mice and rats. The EF standard makes available animals that are free of Proteus spp. and Segmented Filamentous Bacteria (SFB) in addition to organisms absent in our Restricted Flora (RF) health standard. The new EF standard, unique to Taconic, enables investigators to obtain selected Taconic mouse and rat lines that are free of seven well-documented confounding commensal organisms.

“As a pioneer and leader in the development of health standards for laboratory mice and rats, Taconic continues to drive innovations designed to meet the biomedical research industry’s changing needs,” said Taconic Biosciences’ CEO Bob Rosenthal. “The addition of the EF health standard demonstrates our commitment to provide more precisely defined models that help researchers improve the reproducibility of their study results, greatly enhancing their drug discovery process.” Taconic is the only animal model provider with global health standards available to customers worldwide through both Taconic Biosciences, and its distribution partners.

While Proteus spp., SFB, and other commensal organisms found in the human intestinal flora remain the subject of considerable study, their role in human immune response is widely acknowledged. Many publications have identified SFB as key variable in experimental models, playing a role in T-helper cell development and activation, autoimmune diseases, immunoglobulin A (IgA) production, and the development of the mucosal immune system. Proteus spp. has been identified as a study confounder, especially in some immune compromised models.

Read more at: Taconic Biosciences

  • Jim Vitale

    The addition of a new health standard recognizes the increasing role that gut microbiota plays in base animal models used for research purposes. Currently, only thoses organisms shown to be either pathogenic or confounding to research are excluded in the vast majority of rodent animal models. As a community focussed on microbiome research, what to people think is the best health standard to use? Is it Germ Free mice? Or Defined Flora where all organisms present are identified? Or is there yet a different health standard?

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