Dr. Cristina Weiner recently presented a webinar featuring a novel approach to germ-free derivations. She discussed the importance of understanding baseline performance and making incremental process improvements as well as how Taconic Biosciences developed and implemented a new facility design which supports improved germ-free derivation success.
Dr. Cristina Weiner: While recognizing that the germ-free integrity of the animal is most protected and maintained when the animal remains within an isolator, the volume and nature of the projects that we conduct mandates several different inputs into our process. A great example is the source of our embryos, which is an entirely different facility than where the embryo transfer surgical suite is located. As a result of these inputs, process-wise it makes the most sense for Taconic to conduct these procedures outside of an isolator. While recognizing that the greatest risk to the microbial status of the animal is when you remove the animal from the isolator, touch it and manipulate it, rigor and vigilance are required to maintain the integrity of the animal at this point.
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