How the Immune System Impacts Gut Microbiota Evolution

Posted by: | December 14, 2023 | Comments

In a novel study demonstrating the influence of the immune system on gut bacteria evolution, scientists from the Insitito Gulbenkian de Ciencia (IGC) in Portugal have made a solid case for the use of personalized medicine for immunocompromised patients with intestinal problems.

Our gut bacteria, also called “good bacteria” and the “human microbiome,” help the body with digestion in many ways. As we ingest different things, our gut bacteria adapt and evolve to “efficiently cope with different stimuli.” In addition, our immune system constantly keeps track of the bacterial diversity to prevent disease due to a disruption of gut homeostasis. Scientists noticed that immunocompromised people experience a change in gut bacteria composition and saw that as a consequence, the gut bacteria adapt differently than in immunocompetent people.

The team from IGC used mice models to investigate exactly how healthy mice versus mice without immune cells adapt to their diet. They used Escherichia coli (E. coli), one of the very first microbes to colonize the intestine at birth (also a common cause of food poisoning) to observe the differences in gut bacteria evolution between the two groups of mice.

Read more at: labroots

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