Dr. Michael Pellizzon of Research Diets, Inc., recently presented a webinar on the underappreciated impact of rodent diets on microbiome and gut health research, where simple husbandry decisions can profoundly affect both animal model phenotypes and experimental outcomes.
Due to time constraints, many of the questions submitted during the webinar went unanswered. We present a full Q&A here.
Impact of Purified Diets
Q: Can purified diets be used for long-term experiments?
Dr. Michael Pellizzon (MP): Yes. They have been used for very long experiments of one year or more in length. The animals are fine, and depending on the purified diet being fed, they may or may not live as long as those fed grain-based chow.
Q: Can you consider control animals on a purified diet to be healthy and does a purified diet support the normal development of animals?
MP: Purified diets have been used for a long time and have been considered to provide the right nutritional needs to support breeding and a long lifespan. There are some nutritional differences between chows and purified diets which can impact animals, for example in metabolic parameters and morphological changes in the cecum and colon. We think we can improve upon current purified diets by adding different types of fiber from what is currently used.
See More Questions At: Taconic Biosciences