CD1d Modulates Colonic Inflammation in NOD2−/− Mice by Altering the Intestinal Microbial Composition Comprising Acetatifactor muris

Posted by: | May 24, 2019 | Comments

ABSTRACT

AIMS

CD1d Modulates Colonic Inflammation in NOD2−/− Mice by Altering the Intestinal Microbial Composition Comprising Acetatifactor muris

NOD2 and CD1d play a key role in innate immunity by recognizing conserved molecular patterns of pathogens. While NOD2−/− and CD1d−/− mice display structural and functional alterations in Paneth cells, animal studies have reported no impact of NOD2 or CD1d deficiency on experimental colitis. NOD2 mutations increase the susceptibility to inflammatory bowel diseases and the CD1d bound to α-galactosylceramide [α-GalCer] alleviates intestinal inflammation. We evaluated the effect of CD1d modulation on experimental colitis in NOD2−/− mice.

Read more at: Journal of Crohn’s and Colitis

Chansu Lee, Sung Noh Hong, Nam Young Paik, Tae Jun Kim, Eun Ran Kim, Dong Kyung Chang, Young-Ho Kim. Journal of Crohn’s and Colitis. DOI: https://doi.org/10.1093/ecco-jcc/jjz025. May 16 2019.





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