Commensal Microbiota Regulation of Metabolic Networks During Olfactory Dysfunction in Mice

Posted by: | April 2, 2020 | Comments

Olfactory function revealed by the buried food pellet test. The latency times to reach the buried pellet (A) and a visible pellet (B) for GF and SPF mice.

Introduction: Recently, an increasing number of studies have focused on commensal microbiota. These microorganisms have been suggested to impact human health and disease. However, only a small amount of data exists to support the assessment of the influences that commensal microbiota exert on olfactory function.

Methods: We used a buried food pellet test (BFPT) to investigate and compare olfactory functions in adult, male, germ-free (GF) and specific-pathogen-free (SPF) mice, then examined and compared the metabolomic profiles for olfactory bulbs (OBs) isolated from GF and SPF mice to uncover the mechanisms associated with olfactory dysfunction.

Read more at: Neuropsychiatric Disease and Treatment

Wang H, Liu L, Rao X, Chai T, Zeng B, Zhang X, Yu Y, Zhou C, Pu J, Zhou W, Li W, Zhang H, Wei H, & Xie P. Neuropsychiatric Disease and Treatment. DOI: https://doi.org/10.2147/NDT.S236541. 1 March 2020.





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