Depletion of dietary aryl hydrocarbon receptor ligands alters microbiota composition and function

Posted by: | October 28, 2019 | Comments

Fecal microbiota composition is altered in the absence of dietary AhR ligands


The intestinal microbiota is critical for maintaining homeostasis. Dysbiosis, an imbalance in the microbial community, contributes to the susceptibility of several diseases. Many factors are known to influence gut microbial composition, including diet. We have previously shown that fecal immunoglobulin (Ig) A levels are decreased in mice fed a diet free of aryl hydrocarbon receptor (AhR) ligands. Here, we hypothesize this IgA decrease is secondary to diet-induced dysbiosis. We assigned mice to a conventional diet, an AhR ligand-free diet, or an AhR ligand-free diet supplemented with the dietary AhR ligand indole-3-carbinol (I3C). We observed a global alteration of fecal microbiota upon dietary AhR ligand deprivation. Compared to mice on the conventional diet, family Erysipelotrichaceae was enriched in the feces of mice on the AhR ligand-free diet but returned to normal levels upon dietary supplementation with I3C.

Read more at: Scientific Reports

Kyle M. Brawner, Venkata A. Yeramilli, Lennard W. Duck, William Van Der Pol, Lesley E. Smythies, Casey D. Morrow, Charles O. Elson & Colin A. Martin. Scientific Reports. DOI: 11 Oct 2019.

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