Diet-induced remission in chronic enteropathy is associated with altered microbial community structure and synthesis of secondary bile acids

Posted by: | September 12, 2019 | Comments

Identification of microbial community profiles associated with treatment outcome in diet therapy

ABSTRACT

Background

The microbiome has been implicated in the initiation and persistence of inflammatory bowel disease. Despite the fact that diet is one of the most potent modulators of microbiome composition and function and that dietary intervention is the first-line therapy for treating pediatric Crohn’s disease, the relationships between diet-induced remission, enteropathy, and microbiome are poorly understood. Here, we leverage a naturally-occurring canine model of chronic inflammatory enteropathy that exhibits robust remission following nutritional therapy, to perform a longitudinal study that integrates clinical monitoring, 16S rRNA gene amplicon sequencing, metagenomic sequencing, metabolomic profiling, and whole genome sequencing to investigate the relationship between therapeutic diet, microbiome, and disease.

Read more at: Microbiome

Shuai Wang, Rene Martins, Megan C. Sullivan, Elliot S. Friedman, Ana M. Misic, Ayah El-Fahmawi, Elaine Cristina Pereira De Martinis, Kevin O’Brien, Ying Chen, Charles Bradley, Grace Zhang, Alexander S. F. Berry, Christopher A. Hunter, Robert N. Baldassano, Mark P. Rondeau & Daniel P. Beiting. Microbiome. DOI: 10.1186/s40168-019-0740-4. 31 August, 2019.





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