Dietary fructose-induced gut dysbiosis promotes mouse hippocampal neuroinflammation: a benefit of short-chain fatty acids

Posted by: | July 8, 2019 | Comments

ABSTRACT

BACKGROUND

Dietary fructose-induced gut dysbiosis promotes mouse hippocampal neuroinflammation: a benefit of short-chain fatty acids

Western-style diets arouse neuroinflammation and impair emotional and cognitive behavior in humans and animals. Our previous study showed that a high-fructose diet caused the hippocampal neuroinflammatory response and neuronal loss in animals, but the underlying mechanisms remained elusive. Here, alterations in the gut microbiota and intestinal epithelial barrier were investigated as the causes of hippocampal neuroinflammation induced by high-fructose diet.

Read more at: Microbiome

Jian-Mei Li, Rong Yu, Li-Ping Zhang, Shi-Yu Wen, Shui-Juan Wang, Xiao-Yang Zhang, Qiang Xu and Ling-Dong Kong. Microbiome. DOI: https://doi.org/10.1186/s40168-019-0713-7. 29 June 2019.





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