Differential effects of psychotropic drugs on microbiome composition and gastrointestinal function

Posted by: | September 5, 2023 | Comments


Growing evidence supports a role for the microbiota in regulating gut-brain interactions and, thus, psychiatric disorders. Despite substantial scientific efforts to delineate the mechanism of action of psychotropic medications at a central nervous system (CNS) level, there remains a critical lack of understanding on how these drugs might affect the microbiota and gut physiology.


We investigated the antimicrobial activity of psychotropics against two bacterial strain residents in the human gut, Lactobacillus rhamnosus and Escherichia coli. In addition, we examined the impact of chronic treatment with these drugs on microbiota and intestinal parameters in the rat.

Read more at: Springer Link

Sofia Cussotto, et al. Microbiome in Psychiatry & Psychopharmacology. https://doi.org/10.1007/s00213-018-5006-5. 28 August 2023.

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