Early life microbiome perturbation alters pulmonary responses to ozone in male mice

Posted by: | January 29, 2020 | Comments

Early life microbiome perturbation alters pulmonary responses to ozone in male mice

ABSTRACT

Early life changes in the microbiome contribute to the development of allergic asthma, but little is known about the importance of the microbiome for other forms of asthma. Ozone is a nonatopic asthma trigger that causes airway hyperresponsiveness and neutrophil recruitment to the lungs. The purpose of this study was to test the hypothesis that early life perturbations in the gut microbiome influence subsequent responses to ozone. To that end, we placed weanling mouse pups from The Jackson Laboratories or from Taconic Farms in sex‐specific cages either with other mice from the same vendor (same‐housed) or with mice from the opposite vendor (cohoused). Mice were maintained with these cagemates until use.

Read more at: Physiological Reports

Traci A. Brown, Hiroki Tashiro, David I. Kasahara, Youngji Cho, and Stephanie A. Shore. Physiological Reports. DOI: https://doi.org/10.14814/phy2.14290. 24 Jan 2020.





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