Effects of microbiota-directed foods in gnotobiotic animals and undernourished children

Posted by: | July 18, 2019 | Comments

Overview of therapeutic food discovery and testing

Malnutrition and dietary repair

Childhood malnutrition is accompanied by growth stunting and immaturity of the gut microbiota. Even after therapeutic intervention with standard commercial complementary foods, children may fail to thrive. Gehrig et al. and Raman et al. monitored metabolic parameters in healthy Bangladeshi children and those recovering from severe acute malnutrition. The authors investigated the interactions between therapeutic diet, microbiota development, and growth recovery. Diets were then designed using pig and mouse models to nudge the microbiota into a mature post-weaning state that might be expected to support the growth of a child. These were first tested in mice inoculated with age-characteristic gut microbiota.

Read more at: Science

Jeanette L. Gehrig, et. al. Science. DOI: 10.1126/science.aau4732. 12 Jul 2019.

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