Faecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients

Posted by: | December 15, 2020 | Comments

Pearson correlation of faecal microbiomic and metabolomic data for adult and aged mice. ALDEx2 was used to correlate the datasets. +, P < 0.05 (Benjamini-Hochberg). Only rows/columns containing significant data are shown. (8 mice/group)

Abstract

Background

The gut-brain axis and the intestinal microbiota are emerging as key players in health and disease. Shifts in intestinal microbiota composition affect a variety of systems; however, evidence of their direct impact on cognitive functions is still lacking. We tested whether faecal microbiota transplant (FMT) from aged donor mice into young adult recipients altered the hippocampus, an area of the central nervous system (CNS) known to be affected by the ageing process and related functions.

Read more at: Microbiome

Alfonsina D’Amato, et al. Microbiome. DOI: https://doi.org/10.1186/s40168-020-00914-w. 1 October 2020.





Stay up-to-date!
Email Address *
First Name
Last Name

* indicates required
Privacy Policy




Terms & Conditions | Privacy Policy | © 2021 The Translational Microbiome Research Forum