Gut Microbiome as a Potential Factor for Modulating Resistance to Cancer Immunotherapy

Posted by: | January 24, 2020 | Comments

Specific species of bacteria have proven to affect immune response to four different immunotherapies and possible mechanisms in recent studies

Hidden benefits of a fecal transplant

Our gut microbiota evolves as we age, yet its effects on host physiology are not clearly understood. Kundu et al. now attempt to elucidate these effects by transplanting the gut microbiota of either young or old donor mice into young germ-free recipient mice. They report that young germ-free mice receiving gut microbiota transplants from old mouse donors exhibited increased hippocampal neurogenesis, intestinal growth, and activation of the prolongevity FGF21-AMPK-SIRT1 signaling pathways in the liver. Subsequent metagenomic analysis revealed the potential role of butyrate-producing microbes in mediating these effects. These findings collectively suggest that the gut microbiota of an old mouse host may have beneficial effects in a young mouse recipient.

Read more at: Frontiers in Immunology

Lin Shui, Xi Yang, Jian Li, Cheng Yi, Qin Sun, and Hong Zhu. Front. Immunol. DOI: https://doi.org/10.3389/fimmu.2019.02989. 17 Jan 2020.





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