Gut Microbiota Orchestrates Energy Homeostasis during Cold

Posted by: | December 8, 2023 | Comments

Highlights
•Cold exposure leads to marked changes in the gut microbiota composition
•Cold microbiota transplantation increases insulin sensitivity and WAT browning
•Cold exposure or cold transplantation increase the gut size and absorptive capacity
•Reconstitution of cold-suppressed A. muciniphila reverts the increased caloric uptake

Summary
Microbial functions in the host physiology are a result of the microbiota-host co-evolution. We show that cold exposure leads to marked shift of the microbiota composition, referred to as cold microbiota. Transplantation of the cold microbiota to germ-free mice is sufficient to increase insulin sensitivity of the host and enable tolerance to cold partly by promoting the white fat browning, leading to increased energy expenditure and fat loss. During prolonged cold, however, the body weight loss is attenuated, caused by adaptive mechanisms maximizing caloric uptake and increasing intestinal, villi, and microvilli lengths. This increased absorptive surface is transferable with the cold microbiota, leading to altered intestinal gene expression promoting tissue remodeling and suppression of apoptosis—the effect diminished by co-transplanting the most cold-downregulated strain Akkermansia muciniphila during the cold microbiota transfer. Our results demonstrate the microbiota as a key factor orchestrating the overall energy homeostasis during increased demand.

Read more at: Cell

Claire Chevalier, Ozren Stojanović, Didier J. Colin, Nicolas Suarez-Zamorano, Valentina Tarallo, Christelle Veyrat-Durebex, Dorothée Rigo, Salvatore Fabbiano, Ana Stevanović, Stefanie Hagemann, Xavier Montet, Yann Seimbille, Nicola Zamboni, Siegfried Hapfelmeier, Mirko Trajkovski. Cell; Volume 163, Issue 6, p1360–1374, DOI: https://dx.doi.org/10.1016/j.cell.2015.11.004. 3 December 2023





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