Intestinal infection triggers Parkinson’s disease-like symptoms in Pink1−/− mice

Posted by: | July 24, 2019 | Comments

EPEC infection results in the selective degradation of mitochondrial proteins

ABSTRACT

Parkinson’s disease is a neurodegenerative disorder with motor symptoms linked to the loss of dopaminergic neurons in the substantia nigra compacta. Although the mechanisms that trigger the loss of dopaminergic neurons are unclear, mitochondrial dysfunction and inflammation are thought to have key roles1,2. An early-onset form of Parkinson’s disease is associated with mutations in the PINK1 kinase and PRKN ubiquitin ligase genes3. PINK1 and Parkin (encoded by PRKN) are involved in the clearance of damaged mitochondria in cultured cells4, but recent evidence obtained using knockout and knockin mouse models have led to contradictory results regarding the contributions of PINK1 and Parkin to mitophagy in vivo5,6,7,8.

Read more at: Nature

Diana Matheoud, Tyler Cannon, Aurore Voisin, Anna-Maija Penttinen, Lauriane Ramet, Ahmed M. Fahmy, Charles Ducrot, Annie Laplante, Marie-Josée Bourque, Lei Zhu, Romain Cayrol, Armelle Le Campion, Heidi M. McBride, Samantha Gruenheid, Louis-Eric Trudeau & Michel Desjardins. Nature. DOI: 10.1038/s41586-019-1405-y. 17 Jul 2019.





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