Loss of gut barrier integrity triggers activation of islet-reactive T cells and autoimmune diabetes

Posted by: | July 31, 2019 | Comments

Increased intestinal permeability and loss of mucus barrier integrity in NOD mice

Significance

Functional loss of gut barrier integrity with subsequent increased antigen trafficking and occurrence of low-grade intestinal inflammation precede the onset of type 1 diabetes (T1D) in patients and preclinical models, thus suggesting that these events are mechanistically linked to the autoimmune pathogenesis of the disease. However, a causal relationship between increased intestinal permeability and autoimmune diabetes was never demonstrated. Our data show that breakage of gut barrier continuity leads to activation of islet-reactive T cells in the intestine, thus triggering autoimmune diabetes.

Read more at: PNAS

Chiara Sorini, Ilaria Cosorich, Marta Lo Conte, Lorena De Giorgi, Federica Facciotti, Roberta Lucianò, Martina Rocchi, Roberto Ferrarese, Francesca Sanvito, Filippo Canducci, and Marika Falcone. PNAS. DOI: https://doi.org/10.1073/pnas.1814558116. 23 Jul 2019.





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