Microbial Changes and Host Response in F344 Rat Colon Depending on Sex and Age Following a High-Fat Diet

Posted by: | October 15, 2023 | Comments

Gut microbiota, an important component that affects host health, change rapidly and directly in response to altered diet composition. Recently, the role of diet–microbiome interaction on the development of colon cancer has been the focus of interest. Colon cancer occurs more frequently in an aged population, and in males. However, the effect of dietary changes on the gut microbiome has been studied mainly in young males, even though it may vary with age and sex. The aim of this study was to investigate microbial changes and host response in the colons of male and female 6-week-old (young) and 2-year-old (old) Fisher-344 rats exposed to a high-fat diet (HFD). Our results showed that exposure to HFD for 8 weeks decreased the species richness of microbiota (Chao1) and increased Firmicutes/Bacteroidetes ratio only in aged rats, and not in young rats.

Read more at: Frontiers

Sun Min Lee, Nayoung Kim, Hyuk Yoon, Ryoung Hee Nam and Dong He Lee. Frontiers in Microbiology. DOI: https://doi.org/10.3389/fmicb.2018.02236. 24 September 2023.





Stay up-to-date!
Email Address *
First Name
Last Name

* indicates required
Privacy Policy




Terms & Conditions | Privacy Policy | © 2021 The Translational Microbiome Research Forum

As of 3/31 the forum will no longer be active. Please visit taconic.com/events for future bioscience events as Taconic remains committed to leading the industry in microbiome solutions. Thank you for your support.