Microbiota-targeted maternal antibodies protect neonates from enteric infection

Posted by: | January 13, 2020 | Comments

Abstract

mNabs protect neonates from an enteric bacterial pathogen

Although maternal antibodies protect newborn babies from infection, little is known about how protective antibodies are induced without prior pathogen exposure. Here we show that neonatal mice that lack the capacity to produce IgG are protected from infection with the enteric pathogen enterotoxigenic Escherichia coli by maternal natural IgG antibodies against the maternal microbiota when antibodies are delivered either across the placenta or through breast milk. By challenging pups that were fostered by either maternal antibody-sufficient or antibody-deficient dams, we found that IgG derived from breast milk was crucial for protection against mucosal disease induced by enterotoxigenic E. coli. IgG also provides protection against systemic infection by E. coli. Pups used the neonatal Fc receptor to transfer IgG from milk into serum.

Read more: Nature

Wen Zheng, Wenjing Zhao, Meng Wu, Xinyang Song, Florence Caro, Ximei Sun, Francesca Gazzaniga, Giuseppe Stefanetti, Sungwhan Oh, John J. Mekalanos & Dennis L. Kasper. Nature. DOI: https://doi.org/10.1038/s41586-019-1898-4. 08 January 2020.





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