The gut microbiota is a complex ecosystem, affected by both environmental factors and host genetics. Here we aim at uncovering the bacterial taxa whose gut persistence is controlled by host genetic variation. We used a murine model based on inbred lines BALB/c and C57BL/6J and their F1 reciprocal hybrids (♀C57BL/6J×♂BALB/c; ♀BALB/c×♂C57BL/6J). To guarantee genetic similarity of F1, including the sex chromosomes, we used only female mice. Based on 16S rRNA genes sequencing, we found that the genetically different inbred lines present different microbiota, whereas their genetically identical F1 reciprocal hybrids presented similar microbiota. Moreover, the F1 microbial composition differed from that of both parental lines. Twelve taxa were shown to have genetically controlled gut-persistence, while none were found to show maternal effects. Nine of these taxa were dominantly inherited by C57BL/6J line.
Read more at: Applied and Environmental Microbiology