Neurogenesis and prolongevity signaling in young germ-free mice transplanted with the gut microbiota of old mice

Posted by: | November 20, 2019 | Comments

Gut microbiota transplants from old donor mice promote hippocampal neurogenesis in germ-free recipient mice

Hidden benefits of a fecal transplant

Our gut microbiota evolves as we age, yet its effects on host physiology are not clearly understood. Kundu et al. now attempt to elucidate these effects by transplanting the gut microbiota of either young or old donor mice into young germ-free recipient mice. They report that young germ-free mice receiving gut microbiota transplants from old mouse donors exhibited increased hippocampal neurogenesis, intestinal growth, and activation of the prolongevity FGF21-AMPK-SIRT1 signaling pathways in the liver. Subsequent metagenomic analysis revealed the potential role of butyrate-producing microbes in mediating these effects. These findings collectively suggest that the gut microbiota of an old mouse host may have beneficial effects in a young mouse recipient.

Read more at: Science Translational Medicine

Parag Kundu, Hae Ung Lee, Isabel Garcia-Perez, Emmy Xue Yun Tay, Hyejin Kim, Llanto Elma Faylon, Katherine A. Martin, Rikky Purbojati, Daniela I. Drautz-Moses, Sujoy Ghosh, Jeremy K. Nicholson, Stephan Schuster, Elaine Holmes, and Sven Pettersson. Science Translational Medicine. DOI: 10.1126/scitranslmed.aau4760. 13 Nov 2019.

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